Rapid oscillations in blood glucose and plasma free fatty acid concentrations in man.

1973 ◽  
Vol 34 (4) ◽  
pp. 448-451 ◽  
Author(s):  
I A Nimmo ◽  
B J Kirby ◽  
B W Lassers
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid

Effects of Carbohydrate and Chromium Ingestion during Intermittent High-Intensity Exercise to Fatigue

2000 ◽  
Vol 10 (4) ◽  
pp. 476-485 ◽  
Author(s):  
J. Mark Davis ◽  
Ralph S. Welsh ◽  
Nathan A. Alderson
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Fatigue Test ◽  
Exercise Capacity ◽  
High Intensity ◽  
Plasma Free Fatty Acid ◽  
Chromium Picolinate ◽  
Double Blind ◽  
Physically Active

Purpose:This study was designed to test the hypothesis that addition of chromium (Cr) to a carbohydrate-electrolyte drink would enhance the reported benefits of carbohydrate on exercise capacity during intermittent high-intensity shuttle running.Methods:Eight physically active men performed 3 exercise trials while ingesting 6% carbohydrate-electrolyte (CHO), CHO plus chromium picolinate (400 μg) (CHO + Cr+3). or placebo (P) using a double-blind, counterbalanced design. Each trial consisted of 5 × 15 min bouts of shuttle running (walk, sprint, and run at 95 and 55% of estimated V̇O2max, separated by 3-min rest). This was followed by a fatigue test (running alternating 20-m lengths at 55 and 95% of estimated V̇O2, until fatigue).Results:During the standardized shuttle running, blood glucose was higher with both CHO and CHO + Cr+3 than P. Plasma free fatty acid was higher in P than both CHO and CHO + Cr+3 at 75 min of exercise and at fatigue. In the fatigue test, subjects ran longer with both CHO and CHO + Cr+3 than P.Conclusions:The data confirm an ergogenic benefit of ingesting CHO during exercise designed to imitate sports like basketball, soccer, and hockey, but do not support the hypothesis that the addition of Cr would enhance this effect.

scholarly journals The effects of inhibition of gluconeogenesis in suckling newborn rats

1977 ◽  
Vol 162 (1) ◽  
pp. 209-212 ◽  
Author(s):  
P Ferre ◽  
J P Pegorier ◽  
J Girard
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Ketone Bodies ◽  
Plasma Free Fatty Acid ◽  
High Plasma ◽  
Normal Blood ◽  
Newborn Rats ◽  
High Concentrations ◽  
Blood Ketone Bodies

Inhibition of gluconeogenesis with 3-mercaptopicolinate in suckling newborn rats caused a fall in blood [glucose], but no change in their high plasma [free fatty acid] and blood [ketone bodies]. Active gluconeogenesis seems to be more important than sparing of glucose by high concentrations of fat-derived substrates for the maintenance of normal blood [glucose] in suckling newborn rats.

Effect of glucagon on thermogenesis in the pigeon.

1977 ◽  
Vol 232 (5) ◽  
pp. E451
Author(s):  
E Hohtola ◽  
R Hissa ◽  
S Saarela
Keyword(s):  
Oxygen Consumption ◽  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Energy Reserves ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Plasma Ffa ◽  
Adrenergic Blocking

The effects of glucagon injection on temperature regulation and some metabolic parameters were studied in the pigeon. Glucagon (100 microng/kg) always inhibited shivering and caused a fall in the oxygen consumption and body temperature of the unanesthetized pigeon at + 6 degrees C. At + 34 degrees C, the same dose of glucagon had no effect on these parameters. At 22 degrees C, glucagon produced an elevation in plasma free fatty acid (FFA) and blood glucose levels. The rise in FFA at 22 degrees C coincided with the suppression of shivering at 6 degrees C. The glucagon-mediated rise in plasma FFA, but not glucose level, was potentiated by cold ambient temperature. Adrenergic blocking agents given prior to glucagon did not abolish its effects. Phentolamine even prolonged the absence and accelerated the suppression of shivering. A dissociation in the mechanisms by which catecholamines and glucagon suppress shivering is suggested. Although mobilizing energy reserves, glucagon does not seem to be calorigenic in the pigeon at this dose. The interpretation of the changes in plasma FFA levels is discussed in relation to fuel consumption during shivering.

Insulin does not influence muscle glycogenolysis in adrenodemedullated exercising rats

1987 ◽  
Vol 253 (4) ◽  
pp. R535-R540
Author(s):  
H. T. Yang ◽  
K. I. Carlson ◽  
W. W. Winder
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Plasma Insulin ◽  
Insulin Infusion ◽  
Plasma Free Fatty Acid ◽  
The Other ◽  
Elevated Plasma ◽  
Glycogen Utilization ◽  
Blood Glucose Concentrations

Previous reports have indicated that adrenodemedullated (ADM) rats exhibit an impairment in muscle glycogenolysis and elevated plasma insulin during exercise. This study was designed to determine whether the impaired muscle glycogenolysis in ADM rats is due to absence of epinephrine or to the inappropriately elevated plasma insulin. Fasted ADM rats were infused with saline, with epinephrine (0.045 micrograms . 100 g-1 . min-1), or with epinephrine + insulin (1.6, 3.3, 6.6, and 8.3 ng . 100 g-1 . min-1) during a 30-min run on the treadmill (21 m/min, 10% grade). Soleus muscle glycogen decreased from 5.1 +/- 0.2 mg/g in resting ADM rats to 4.0 +/- 0.2, 0.8 +/- 0.1, and 0.8 +/- 0.1 mg/g in the exercising saline-, epinephrine-, and epinephrine + insulin (8.3 ng . 100 g-1 . min-1)-infused rats, respectively. Glycogen utilization in gastrocnemius and red and white quadriceps muscles during exercise was likewise unaffected by insulin infusion. Blood glucose concentrations were 3.75 +/- 0.08, 2.65 +/- 0.14, 3.93 +/- 0.20, and 2.03 +/- 0.09 mM in the same groups at the end of exercise. Blood lactate was 50% lower and the blood 3-hydroxybutyrate and plasma free fatty acid concentrations were significantly higher in the ADM + saline rats than the other exercising rats. We conclude that inappropriately elevated plasma insulin does not impair epinephrine-stimulated muscle glycogenolysis in fasted ADM rats during exercise.

HYPOGLYCEMIA AND HYPERINSULINEMIA ASSOCIATED WITH ERYTHROBLASTOSIS FETALIS

PEDIATRICS ◽  
1969 ◽  
Vol 43 (2) ◽  
pp. 217-225
Author(s):  
Kari O. Raivio ◽  
Kalle Österlund
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Binding Capacity ◽  
Plasma Free Fatty Acid ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Plasma Insulin Levels ◽  
Low Glucose ◽  
Bilirubin Binding

In a survey of blood glucose levels in 232 erythroblastotic infants during the first 3 days of life, 12 cases of significant hypoglycemia were revealed. Most of these had a severe primary disease; the incidence of hypoglycemia was 17.8% in patients with cord hemoglobin concentrations below 10 gm per 100 ml and 1.9% in those with higher cord hemoglobin levels. The low glucose values were usually observed during the first day of life and were unassociated with recognizable symptoms. Plasma insulin levels, determined in 39 cases before age 24 hours and prior to treatment, were shown to be negatively correlated with the cord hemoglobin concentrations. Hyperinsulinemia, directly correlated with the severity of the erythroblastosis, is postulated to be the cause of the low blood glucose levels. As another consequence of the hyperinsulinemia, a depression of the plasma free fatty acid concentrations was documented. The mechanism of the hyperinsulinemia, the therapeutic and prognostic implications of the hypoglycemia, as well as the effect of the depression of free fatty acid levels on the bilirubin-binding capacity of serum are briefly discussed.

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