Branched-chain amino acid metabolism and alanine formation in rat diaphragm muscle in vitro. Effects of dichloroacetate

Biochemical Journal ◽

10.1042/bj2230831 ◽

1984 ◽

Vol 223 (3) ◽

pp. 831-835 ◽

Author(s):

K Snell ◽

D A Duff

Keyword(s):

Pyruvate Dehydrogenase ◽

Amino Acid Metabolism ◽

Acid Metabolism ◽

Diaphragm Muscle ◽

Rat Diaphragm ◽

Branched Chain Amino Acid ◽

In Vitro Effects ◽

Dichloroacetate (which activates pyruvate dehydrogenase) decreases the release of alanine, pyruvate and lactate in hemidiaphragm incubations with valine. Dichloroacetate interferes with alanine formation by diverting pyruvate into oxidative pathways, which not only limits pyruvate availability for direct transamination to form alanine but also indirectly affects branched-chain amino acid transamination by limiting 2-oxoglutarate regeneration from glutamate.

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Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism

European Journal of Human Genetics ◽

10.1038/ejhg.2015.106 ◽

2015 ◽

Vol 24 (1) ◽

pp. 142-145 ◽

Author(s):

Mattijs M Heemskerk ◽

Vanessa JA van Harmelen ◽

Ko Willems van Dijk ◽

Jan Bert van Klinken

Keyword(s):

Lactate Dehydrogenase ◽

Amino Acid Metabolism ◽

Acid Metabolism ◽

Branched Chain Amino Acid ◽

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The effect of clofibric acid on muscle branched-chain amino acid metabolism and alanine release in vitro

Biochemical Society Transactions ◽

10.1042/bst0110289a ◽

1983 ◽

Vol 11 (3) ◽

pp. 289-290 ◽

Author(s):

JUDITH M. TROKE ◽

DAVID A. DUFF ◽

KEITH SNELL

Keyword(s):

Amino Acid Metabolism ◽

Acid Metabolism ◽

Clofibric Acid ◽

Branched Chain Amino Acid ◽

Release In Vitro ◽

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Faculty Opinions recommendation of Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725306028.793542204 ◽

2018 ◽

Author(s):

Miriam Vos

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Amino Acid Metabolism ◽

Acid Metabolism ◽

Nonalcoholic Fatty Liver ◽

Branched Chain Amino Acid ◽

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In Vivo Imaging of Branched Chain Amino Acid Metabolism in Prostate Cancer

10.21236/ada590428 ◽

2013 ◽

Author(s):

Daniel Spielman

Keyword(s):

Prostate Cancer ◽

In Vivo Imaging ◽

Amino Acid Metabolism ◽

Acid Metabolism ◽

Branched Chain Amino Acid ◽

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Aqueous Humor Analysis Identifies Higher Branched Chain Amino Acid Metabolism as a Marker for Human Leukocyte Antigen-B27 Acute Anterior Uveitis and Disease Activity

American Journal of Ophthalmology ◽

10.1016/j.ajo.2018.10.004 ◽

2019 ◽

Vol 198 ◽

pp. 97-110 ◽

Author(s):

Fleurieke H. Verhagen ◽

Edwin C.A. Stigter ◽

Mia L. Pras-Raves ◽

Boudewijn M.T. Burgering ◽

Saskia M. Imhof ◽

...

Keyword(s):

Disease Activity ◽

Anterior Uveitis ◽

Amino Acid Metabolism ◽

Acid Metabolism ◽

Human Leukocyte ◽

Acute Anterior Uveitis ◽

Leukocyte Antigen ◽

Branched Chain Amino Acid ◽

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Effects of intravenously infused carnitine on branched-chain amino acid metabolism in fasted and parenterally-fed rats

Clinical Nutrition ◽

10.1016/0261-5614(87)90104-x ◽

1987 ◽

Vol 6 ◽

pp. 25

Keyword(s):

Amino Acid Metabolism ◽

Acid Metabolism ◽

Branched Chain Amino Acid ◽

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Altered branched chain amino acid metabolism

Current Opinion in Cardiology ◽

10.1097/hco.0000000000000552 ◽

2018 ◽

Vol 33 (5) ◽

pp. 558-564 ◽

Author(s):

Deirdre K. Tobias ◽

Samia Mora ◽

Subodh Verma ◽

Patrick R. Lawler

Keyword(s):

Amino Acid Metabolism ◽

Acid Metabolism ◽

Branched Chain Amino Acid ◽

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Intravenously infused carnitine: influence on protein and branched-chain amino acid metabolism in starved and parenterally fed rats

American Journal of Clinical Nutrition ◽

10.1093/ajcn/48.3.570 ◽

1988 ◽

Vol 48 (3) ◽

pp. 570-574 ◽

Author(s):

J A Vazquez ◽

H S Paul ◽

S A Adibi

Keyword(s):

Amino Acid Metabolism ◽

Acid Metabolism ◽

Branched Chain Amino Acid ◽

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Short communication: Colostrum versus formula: Effects on mRNA expression of genes related to branched-chain amino acid metabolism in neonatal dairy calves

Journal of Dairy Science ◽

10.3168/jds.2020-18429 ◽

2020 ◽

Vol 103 (10) ◽

pp. 9656-9666 ◽

Author(s):

Morteza H. Ghaffari ◽

Hassan Sadri ◽

Harald M. Hammon ◽

Julia Steinhoff-Wagner ◽

Nico Henschel ◽

...

Keyword(s):

Mrna Expression ◽

Amino Acid Metabolism ◽

Short Communication ◽

Acid Metabolism ◽

Dairy Calves ◽

Branched Chain Amino Acid ◽

Expression Of Genes ◽

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Pancreatic stellate cells regulate branched-chain amino acid metabolism in pancreatic cancer

Annals of Translational Medicine ◽

10.21037/atm-21-761 ◽

2021 ◽

Vol 9 (5) ◽

pp. 417-417

Author(s):

Wenna Jiang ◽

Lu Qiao ◽

Yawei Han ◽

Aimin Zhang ◽

Haohua An ◽

...

Keyword(s):

Pancreatic Cancer ◽

Amino Acid Metabolism ◽

Acid Metabolism ◽

Stellate Cells ◽

Pancreatic Stellate Cells ◽

Branched Chain Amino Acid ◽

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