Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments

The intracellular compartmentalization in rat liver of the membrane-associated convertases furin and proprotein convertase 7 (PC7)/lymphoma PC (LPC) was investigated by analytical subcellular fractionation. In control animals, both enzymes were found to localize in fractions depleted of endoplasmic reticulum, cis-Golgi and lysosomal markers, but to co-distribute with the Golgi marker galactosyltransferase and the trans-Golgi network (TGN) marker TGN38. After overloading Golgi-derived vesicles with very-low-density lipoproteins (VLDL) by feeding rats with ethanol, the distribution of PC7/LPC was shifted markedly towards lower densities, in contrast with those of furin and the TGN marker. This provides support for the TGN localization of endogenously expressed furin and indicates that, at steady state, a considerable proportion of PC7/LPC may be associated with vesicles derived from the TGN.

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Assembly of very low density lipoproteins in rat liver: a study of nascent particles recovered from the rough endoplasmic reticulum.

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)39874-6 ◽

1995 ◽

Vol 36 (3) ◽

pp. 395-406

Author(s):

L L Swift

Keyword(s):

Endoplasmic Reticulum ◽

Rat Liver ◽

Rough Endoplasmic Reticulum ◽

Low Density Lipoproteins ◽

Low Density ◽

Very Low Density Lipoproteins

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Dietary fish oils inhibit early events in the assembly of very low density lipoproteins and target apoB for degradation within the rough endoplasmic reticulum of hamster hepatocytes

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)32455-x ◽

1999 ◽

Vol 40 (3) ◽

pp. 504-514 ◽

Cited By ~ 2

Author(s):

John S. Kendrick ◽

Joan A. Higgins

Keyword(s):

Endoplasmic Reticulum ◽

Rough Endoplasmic Reticulum ◽

Low Density Lipoproteins ◽

Fish Oils ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Dietary Fish

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Effects of amphetamine and fenfluramine on the net release of triglycerides of very low density lipoproteins by slices of rat liver

Biochemical Pharmacology ◽

10.1016/0006-2952(72)90108-6 ◽

1972 ◽

Vol 21 (8) ◽

pp. 1143-1150 ◽

Cited By ~ 10

Author(s):

Julian B. Marsh ◽

Adalgisa Bizzi

Keyword(s):

Rat Liver ◽

Low Density Lipoproteins ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Net Release

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Uptake and degradation of human very-low-density lipoproteins by rat liver endothelial cells in culture

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ◽

10.1016/0005-2760(85)90003-7 ◽

1985 ◽

Vol 834 (3) ◽

pp. 308-315 ◽

Cited By ~ 15

Author(s):

Stefan Gustafson ◽

Ann-Margret Östlund-Lindqvist ◽

Bengt Vessby

Keyword(s):

Endothelial Cells ◽

Rat Liver ◽

Low Density Lipoproteins ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Cells In Culture ◽

Liver Endothelial Cells

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The Conversion of ApoB100 Low Density Lipoprotein/High Density Lipoprotein Particles to ApoB100 Very Low Density Lipoproteins in Response to Oleic Acid Occurs in the Endoplasmic Reticulum and Not in the Golgi in McA RH7777 Cells

Journal of Biological Chemistry ◽

10.1074/jbc.m306920200 ◽

2003 ◽

Vol 278 (43) ◽

pp. 42643-42651 ◽

Cited By ~ 35

Author(s):

Junji Yamaguchi ◽

Mary V. Gamble ◽

Donna Conlon ◽

Jun-shan Liang ◽

Henry N. Ginsberg

Keyword(s):

Endoplasmic Reticulum ◽

Oleic Acid ◽

High Density Lipoprotein ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density Lipoproteins ◽

High Density ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Lipoprotein Particles

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Biogenesis of very-low-density lipoproteins in rat liver. Intracellular distribution of apolipoprotein B

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1987.tb11066.x ◽

1987 ◽

Vol 164 (2) ◽

pp. 357-367 ◽

Cited By ~ 17

Author(s):

Laurence WONG ◽

Richard M. PINO

Keyword(s):

Rat Liver ◽

Apolipoprotein B ◽

Low Density Lipoproteins ◽

Intracellular Distribution ◽

Low Density ◽

Very Low Density Lipoproteins

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Assembly and secretion of very low density lipoproteins by rat liver following inhibition of protein synthesis with cycloheximide

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ◽

10.1016/0005-2760(73)90214-2 ◽

1973 ◽

Vol 306 (1) ◽

pp. 106-114 ◽

Cited By ~ 23

Author(s):

H. Bar-On ◽

A.I. Kook ◽

O. Stein ◽

Y. Stein

Keyword(s):

Protein Synthesis ◽

Rat Liver ◽

Low Density Lipoproteins ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Inhibition Of Protein Synthesis

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Role of the liver in the degradation of very low density lipoproteins: a study of lipolysis by heparin releasable liver lipase and uptake during isolated rat liver perfusion

European Journal of Clinical Investigation ◽

10.1111/j.1365-2362.1981.tb01834.x ◽

1981 ◽

Vol 11 (3) ◽

pp. 151-159 ◽

Cited By ~ 21

Author(s):

E. M. BERRY ◽

R. ALDINI ◽

H. BARON ◽

S. EISENBERG

Keyword(s):

Rat Liver ◽

Liver Perfusion ◽

Low Density Lipoproteins ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Isolated Rat Liver ◽

Rat Liver Perfusion ◽

Isolated Rat

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Mature VLDL triggers the biogenesis of a distinct vesicle from the trans-Golgi network for its export to the plasma membrane

Biochemical Journal ◽

10.1042/bj20131215 ◽

2014 ◽

Vol 459 (1) ◽

pp. 47-58 ◽

Cited By ~ 13

Author(s):

Tanvir Hossain ◽

Aladdin Riad ◽

Shaila Siddiqi ◽

Sampath Parthasarathy ◽

Shadab A. Siddiqi

Keyword(s):

Plasma Membrane ◽

Low Density Lipoproteins ◽

Low Density ◽

Very Low Density Lipoproteins ◽

Trans Golgi Network ◽

Golgi Transport ◽

Golgi Network ◽

Insight Into

We have identified a novel vesicle that transports mature very-low-density lipoproteins from the trans-Golgi network to the plasma membrane. Identification of this vesicle provides new insight into the mechanism that regulates the post-Golgi transport of mature very-low-density lipoproteins.

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