The design and biological properties of potent and selective inhibitors of protein kinase C

1992 ◽  
Vol 20 (2) ◽  
pp. 419-425 ◽  
Author(s):  
J. S. Nixon ◽  
J. Bishop ◽  
D. Bradshaw ◽  
P. D. Davis ◽  
C. H. Hill ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Biological Properties ◽  
Selective Inhibitors ◽  
Kinase C

Protein Kinase C in Cell Signaling: Strategies for the Development of Selective Inhibitors

1995 ◽  
pp. 87-100 ◽  
Author(s):  
P. M. Blumberg ◽  
G. Acs ◽  
P. Acs ◽  
L. B. Areces ◽  
M. G. Kazanietz ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Signaling ◽  
Selective Inhibitors ◽  
Kinase C ◽  
Signaling Strategies

scholarly journals Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2336 ◽  
Author(s):  
Simon Remy ◽  
Marc Litaudon
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Virus Replication ◽  
Mechanism Of Action ◽  
Chikungunya Virus ◽  
Cytopathic Effect ◽  
Structural Diversity ◽  
Biological Properties ◽  
Kinase C ◽  
Structure Activity

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure–activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.

Selective inhibitors of protein kinase C in a model of graft-vs-host disease

1994 ◽  
Vol 4 (20) ◽  
pp. 2451-2456 ◽  
Author(s):  
James P. Demers ◽  
William E. Hageman ◽  
Sigmond G. Johnson ◽  
Dieter H. Klaubert ◽  
Richard A. Look ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Selective Inhibitors ◽  
Host Disease ◽  
Kinase C ◽  
Graft Vs Host Disease

ChemInform Abstract: Phenylamino-pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

ChemInform ◽  
2010 ◽  
Vol 27 (46) ◽  
pp. no-no
Author(s):  
J. ZIMMERMANN ◽  
G. CARAVATTI ◽  
H. METT ◽  
T. MEYER ◽  
M. MUELLER ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Selective Inhibitors ◽  
New Class ◽  
Kinase C

Total Synthesis of Amino-Functionalized Calphostin Analogs as Potent and Selective Inhibitors of Protein Kinase C (PKC)

2016 ◽  
Vol 37 (10) ◽  
pp. 1586-1592
Author(s):  
Hyoyeon Kim ◽  
Choon-Ho Song ◽  
Dae-Hyuk Kim ◽  
Nam-Gin Jung ◽  
Seung-Jae Lee ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Total Synthesis ◽  
Selective Inhibitors ◽  
Kinase C

Novel substituted indolocarbazoles as potent and selective inhibitors of protein kinase C

1995 ◽  
Vol 5 (23) ◽  
pp. 2841-2844 ◽  
Author(s):  
Guojian Xie ◽  
Hiroyuki Nagata ◽  
Tatsuya Tamaoki ◽  
J.William Lown
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Selective Inhibitors ◽  
Kinase C

Tannins as selective inhibitors of protein kinase C

1992 ◽  
Vol 2 (3) ◽  
pp. 239-244 ◽  
Author(s):  
Yoshiki Kashiwada ◽  
Gen-ichiro Nonaka ◽  
Itsuo Nishioka ◽  
Lawrence M. Ballas ◽  
Jack B. Jiang ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Selective Inhibitors ◽  
Kinase C
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