BCG (Bacille Calmette–Guérin) HspCs (heat-shock protein–peptide complexes) induce T-helper 1 responses and protect against live challenge in a murine aerosol challenge model of pulmonary tuberculosis

2004 ◽  
Vol 32 (4) ◽  
pp. 626-628 ◽  
Author(s):  
C.A.L.S. Colaco ◽  
C.R. Bailey ◽  
J. Keeble ◽  
K.B. Walker
Keyword(s):  
Heat Shock ◽  
Pulmonary Tuberculosis ◽  
Immune Responses ◽  
Heat Shock Protein ◽  
T Helper ◽  
T Helper 1 ◽  
Bacille Calmette Guerin ◽  
Vaccine Candidates ◽  
Peptide Complexes ◽  
Further Development

The need for an effective TB (tuberculosis) vaccine remains acute, with tuberculosis still one of the major killers worldwide and 3 million new infections annually. We report here on the immune responses elicited by HspCs (heat-shock protein–peptide complexes) isolated from BCG (Bacille Calmette–Guérin) vaccine. These HspCs elicit both the appropriate cellular and protective immune responses required to merit their further development as TB vaccine candidates.

Anti-tumor effect of heat shock protein 70-Peptide complexes on A-549 cells

2007 ◽  
Vol 19 (3) ◽  
pp. 210-215 ◽  
Author(s):  
Hong-qi Wang ◽  
Chen-xia Hu ◽  
Ling Hu ◽  
Wei-xi Shen ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Peptide Complexes

Heat shock protein 70 / MAGE-1 tumor vaccine can enhance the potency of MAGE-1–specific cellular immune responses in vivo

2004 ◽  
Vol 53 (9) ◽  
pp. 825-834 ◽  
Author(s):  
Jing Ye ◽  
Guang-Sheng Chen ◽  
Hong-Ping Song ◽  
Zeng-Shan Li ◽  
Ya-Yu Huang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Immune Responses ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Tumor Vaccine ◽  
Cellular Immune Responses ◽  
Cellular Immune

30-OR: Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells

2008 ◽  
Vol 69 ◽  
pp. S113
Author(s):  
Constança Figueiredo ◽  
Miriam Wittmann ◽  
Dressel Ralf ◽  
Rainer Blasczyk ◽  
Eiz-Vesper Britta
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
T Helper Cells ◽  
Heat Shock Protein 70 ◽  
T Helper ◽  
Helper Cells

scholarly journals CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 ◽  
Vol 186 (10) ◽  
pp. 1623-1631 ◽  
Author(s):  
Rose S. Chu ◽  
Oleg S. Targoni ◽  
Arthur M. Krieg ◽  
Paul V. Lehmann ◽  
Clifford V. Harding
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Cpg Odn ◽  
T Helper ◽  
T Helper 1 ◽  
Cpg Oligodeoxynucleotides ◽  
Cytokine Pattern ◽  
Incomplete Freund’S Adjuvant ◽  
Ifn Γ ◽  
Hen Egg

Synthetic oligodeoxynucleotides (ODN) that contain unmethylated CpG motifs (CpG ODN) induce macrophages to secrete IL-12, which induces interferon (IFN)-γ secretion by natural killer (NK) cells. Since these cytokines can induce T helper 1 (Th1) differentiation, we examined the effects of coadministered CpG ODN on the differentiation of Th responses to hen egg lysozyme (HEL). In both BALB/c (Th2-biased) and B10.D2 (Th1-biased) mice, immunization with HEL in incomplete Freund's adjuvant (IFA) resulted in Th2-dominated immune responses characterized by HEL-specific secretion of IL-5 but not IFN-γ. In contrast, immunization with IFA-HEL plus CpG ODN switched the immune response to a Th1-dominated cytokine pattern, with high levels of HEL-specific IFN-γ secretion and decreased HEL-specific IL-5 production. IFA-HEL plus CpG ODN also induced anti-HEL IgG2a (a Th1-associated isotype), which was not induced by IFA-HEL alone. Control non–CpG ODN did not induce IFN-γ or IgG2a, excepting lesser increases in B10.D2 (Th1-biased) mice. Thus, CpG ODN provide a signal to switch on Th1-dominated responses to coadministered antigen and are potential adjuvants for human vaccines to elicit protective Th1 immunity.

Mucosal immune responses induced by DNA vaccine encoding heat shock protein B

2001 ◽  
Vol 120 (5) ◽  
pp. A589
Author(s):  
Isami Todoroki ◽  
Takashi Joh ◽  
Masayuki Miyashita ◽  
Katsushi Watanabe ◽  
Kyojl Seno ◽  
...  
Keyword(s):  
Heat Shock ◽  
Immune Responses ◽  
Heat Shock Protein ◽  
Dna Vaccine ◽  
Mucosal Immune Responses ◽  
Protein B

60-kDa heat shock protein of Chlamydia pneumoniae promotes a T helper type 1 immune response through IL-12/IL-23 production in monocyte-derived dendritic cells

2006 ◽  
Vol 8 (3) ◽  
pp. 714-720 ◽  
Author(s):  
Clara Maria Ausiello ◽  
Giorgio Fedele ◽  
Raffaella Palazzo ◽  
Fabiana Spensieri ◽  
Alessandra Ciervo ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Chlamydia Pneumoniae ◽  
T Helper ◽  
Helper Type
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