HAUSP/USP7 as an Epstein–Barr virus target
2004 ◽
Vol 32
(5)
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pp. 731-732
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Keyword(s):
USP7 (also called HAUSP) is a de-ubiquitinating enzyme recently identified as a key regulator of the p53–mdm2 pathway, which stabilizes both p53 and mdm2. We have discovered that the Epstein–Barr nuclear antigen 1 protein of Epstein–Barr virus binds with high affinity to USP7 and disrupts the USP7–p53 interaction. The results have important implications for the role of Epstein–Barr nuclear antigen 1 in the cellular immortalization that is typical of an Epstein–Barr virus latent infection.
1989 ◽
Vol 70
(11)
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pp. 2989-3002
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2014 ◽
Vol 272
(1-2)
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pp. 56-61
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Keyword(s):
Keyword(s):
2013 ◽
Vol 20
(6)
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pp. 747-750
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2013 ◽
Vol 94
(3)
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pp. 497-506
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Keyword(s):
1985 ◽
Vol 4
(11)
◽
pp. 2955-2959
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Keyword(s):
1997 ◽
Vol 272
(42)
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pp. 26434-26440
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