Oscillations in transcription factor dynamics: a new way to control gene expression

2004 ◽  
Vol 32 (6) ◽  
pp. 1090-1092 ◽  
Author(s):  
D.E. Nelson ◽  
V. Sée ◽  
G. Nelson ◽  
M.R.H. White
Keyword(s):  
Gene Expression ◽  
Feedback Loop ◽  
Dynamic Control ◽  
Nuclear Factor Κb ◽  
Negative Feedback Loop ◽  
Network Motifs ◽  
Nuclear Factor ◽  
Control Gene ◽  
Control Gene Expression

Oscillations in second-messenger signalling (e.g. calcium) have previously been shown to be important in the control of transcription. More recently, oscillations in localization and absolute levels of transcription factors and their regulators have been identified. Here we discuss the role of network motifs such as the negative feedback loop and their role in oscillatory signalling, and how oscillations in components of the nuclear factor κB signalling pathway are important to the dynamic control of transcription in response to a cytokine stimulus.

scholarly journals Role of Nuclear Factor-κB in the Antiviral Action of Interferon and Interferon-regulated Gene Expression

2004 ◽  
Vol 279 (30) ◽  
pp. 31304-31311 ◽  
Author(s):  
Lawrence M. Pfeffer ◽  
Jong-Gwan Kim ◽  
Susan R. Pfeffer ◽  
Dennis J. Carrigan ◽  
Darren P. Baker ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Antiviral Action ◽  
Regulated Gene Expression

scholarly journals Roles of Diffusible Signals in Communication Among Plant-Associated Bacteria

2007 ◽  
Vol 97 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Leland S. Pierson ◽  
Elizabeth A. Pierson
Keyword(s):  
Gene Expression ◽  
Control Gene ◽  
Bacterial Host ◽  
Diverse Range ◽  
Associated Bacteria ◽  
Host Interactions ◽  
Control Gene Expression ◽  
Pseudomonas Species ◽  
Interkingdom Communication

In nature, Pseudomonas species compete and co-exist in mixed communities with a diversity of prokaryotic and eukaryotic micro- and macroorganisms. Many bacteria produce various signals that control gene expression and thus contribute to specific bacterial behaviors and coordinate essential functions with other members of the community. The best-studied signaling compounds are N-acyl-homoserine lactones (AHLs), which are involved in quorum sensing (QS) regulation and are produced by a diverse range of bacterial taxa. To date, research on QS has focused on how signals control gene expression in the bacterial cell and the role of these signals in positive and negative communication among different groups of organisms. Additionally, mechanisms for AHL decay and AHL utilization as sole carbon/energy sources have been identified. Some host organisms produce compounds that can mimic AHLs, and some bacterial signals can influence host gene expression. Thus, interkingdom communication may be more widespread than previously believed. Our current understanding of individual, community and bacterial-host interactions is still in its infancy and there are many exciting discoveries yet to be made.

Regulation of cyclin D1 gene expression

2010 ◽  
Vol 38 (1) ◽  
pp. 217-222 ◽  
Author(s):  
Ini-Isabée Witzel ◽  
Li Fang Koh ◽  
Neil D. Perkins
Keyword(s):  
Gene Expression ◽  
Cyclin D1 ◽  
Rna Processing ◽  
Dominant Role ◽  
Rna Stability ◽  
Transcriptional Regulator ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Post Transcriptional Regulation

Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss the ability of the NF-κB (nuclear factor κB)/IKK [IκB (inhibitor of NF-κB) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability.

Role of microRNAs in haemopoiesis, heart hypertrophy and cancer

2008 ◽  
Vol 36 (6) ◽  
pp. 1206-1210 ◽  
Author(s):  
Laura Fontana ◽  
Antonio Sorrentino ◽  
Gianluigi Condorelli ◽  
Cesare Peschle
Keyword(s):  
Gene Expression ◽  
Essential Role ◽  
Recent Literature ◽  
Human Diseases ◽  
Present Review ◽  
Heart Hypertrophy ◽  
Control Gene ◽  
Research Areas ◽  
Control Gene Expression

miRNAs (microRNAs) are important regulatory molecules that control gene expression in all eukaryotes. miRNAs play an essential role in basic cellular activities such as proliferation, differentiation, morphogenesis and apoptosis. In haemopoiesis, several miRNA-based pathways have been identified. Importantly, miRNA mutations or mis-expression correlate with various human diseases. In cancer, deregulated miRNAs can function as tumour suppressors or oncogenes. The present review focuses on the recent literature concerning the role of miRNAs in three different research areas: haematology, cardiology and oncology, with particular focus on the results obtained by our group.

scholarly journals The central role of RNA in the genetic programming of complex organisms

2010 ◽  
Vol 82 (4) ◽  
pp. 933-939 ◽  
Author(s):  
John S. Mattick
Keyword(s):  
Gene Expression ◽  
Control Gene ◽  
Animal Kingdom ◽  
Protein Coding ◽  
Coding Sequences ◽  
Protein Coding Genes ◽  
Control Gene Expression ◽  
Large Numbers ◽  
The Brain

Notwithstanding lineage-specific variations, the number and type of protein-coding genes remain relatively static across the animal kingdom. By contrast there has been a massive expansion in the extent of genomic non-proteincoding sequences with increasing developmental complexity. These non-coding sequences are, in fact, transcribed in a regulated manner to produce large numbers of large and small non-protein-coding RNAs that control gene expression at many levels including chromatin architecture, post-transcriptional processing and translation. Moreover, many RNAs are edited, especially in the nervous system, which may be the basis of epigenome-environment interactions and the function of the brain.

scholarly journals Essential role of nuclear factor-κB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes

Blood ◽  
2008 ◽  
Vol 112 (4) ◽  
pp. 1453-1460 ◽  
Author(s):  
Marcos Luengo-Blanco ◽  
Carolina Prando ◽  
Jacinta Bustamante ◽  
Walmir Cutrim Aragão-Filho ◽  
Paulo Vitor Soeiro Pereira ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nadph Oxidase ◽  
Ectodermal Dysplasia ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
U937 Cells ◽  
Cybb Gene ◽  
Anhidrotic Ectodermal Dysplasia ◽  
Ncf1 Gene

AbstractThis work investigated the functional role of nuclear factor–κB (NF-κB) in respiratory burst activity and in expression of the human phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase genes CYBB, CYBA, NCF1, and NCF2. U937 cells with a stably transfected repressor of NF-κB (IκBα-S32A/S36A) demonstrated significantly lower superoxide release and lower CYBB and NCF1 gene expression compared with control U937 cells. We further tested Epstein-Barr virus (EBV)-transformed B cells from patients with anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID), an inherited disorder of NF-κB function. Superoxide release and CYBB gene expression by EDA-ID cells were significantly decreased compared with healthy cells and similar to cells from patients with X-linked chronic granulomatous disease (X910 CGD). NCF1 gene expression in EDA-ID S32I cells was decreased compared with healthy control cells and similar to that in autosomal recessive (A470) CGD cells. Gel shift assays demonstrated loss of recombinant human p50 binding to a NF-κB site 5′ to the CYBB gene in U937 cells treated with NF-κB inhibitors, repressor-transfected U937 cells, and EDA-ID patients' cells. Zymosan phagocytosis was not affected by transfection of U937 cells with the NF-κB repressor. These studies show that NF-κB is necessary for CYBB and NCF1 gene expression and activation of the phagocyte NADPH oxidase in this model system.

scholarly journals Interrogation of Inhibitor of Nuclear Factor κB α/Nuclear Factor κB (IκBα/NF-κB) Negative Feedback Loop Dynamics

2012 ◽  
Vol 287 (37) ◽  
pp. 31359-31370 ◽  
Author(s):  
Britney L. Moss ◽  
Adnan Elhammali ◽  
Tiffanie Fowlkes ◽  
Shimon Gross ◽  
Anant Vinjamoori ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Feedback Loop ◽  
Nuclear Factor Κb ◽  
Negative Feedback Loop ◽  
Nuclear Factor ◽  
Loop Dynamics
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