Putting the fizz into chemistry: applications of supercritical carbon dioxide in tissue engineering, drug delivery and synthesis of novel block copolymers

2007 ◽  
Vol 35 (3) ◽  
pp. 516-521 ◽  
Author(s):  
H. Tai ◽  
V.K. Popov ◽  
K.M. Shakesheff ◽  
S.M. Howdle
Keyword(s):  
Carbon Dioxide ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Block Copolymers ◽  
Supercritical Carbon Dioxide ◽  
Drug Carriers ◽  
Controlled Polymerization ◽  
Polymeric Scaffolds ◽  
Potential Use ◽  
Supercritical Carbon

This paper describes the recent progress at Nottingham towards the exploitation of the unique properties of scCO2 (supercritical carbon dioxide) for the preparation of polymeric scaffolds for tissue engineering applications and new devices for controlled drug delivery, as well as the synthesis of novel block copolymers by the combination of eROP (enzymatic ring opening polymerization) and controlled polymerization methods for the potential use as drug carriers.

Supercritical carbon dioxide foaming of elastomer/heterocyclic methacrylate blends as scaffolds for tissue engineering

2005 ◽  
Vol 15 (46) ◽  
pp. 4881 ◽  
Author(s):  
John J. A. Barry ◽  
Showan N. Nazhat ◽  
Felicity R. A. J. Rose ◽  
Atticus H. Hainsworth ◽  
Colin A. Scotchford ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Tissue Engineering ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Carbon

scholarly journals Supercritical carbon dioxide design strategies: from drug carriers to soft killers

2015 ◽  
Vol 373 (2057) ◽  
pp. 20150009 ◽  
Author(s):  
Ana Aguiar-Ricardo ◽  
Vasco D. B. Bonifácio ◽  
Teresa Casimiro ◽  
Vanessa G. Correia
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Three Dimensional ◽  
Polymeric Materials ◽  
Drug Carriers ◽  
Water Soluble ◽  
Materials Processing ◽  
Design Strategies ◽  
Simple Economic ◽  
Supercritical Carbon

The integrated use of supercritical carbon dioxide (scCO 2 ) and micro- and nanotechnologies has enabled new sustainable strategies for the manufacturing of new medications. ‘Green’ scCO 2 -based methodologies are well suited to improve either the synthesis or materials processing leading to the assembly of three-dimensional multifunctional constructs. By using scCO 2 either as C1 feedstock or as solvent, simple, economic, efficient and clean routes can be designed to synthesize materials with unique properties such as polyurea dendrimers and oxazoline-based polymers/oligomers. These new biocompatible, biodegradable and water-soluble polymeric materials can be engineered into multifunctional constructs with antimicrobial activity, targeting moieties, labelling units and/or efficiently loaded with therapeutics. This mini-review highlights the particular features exhibited by these materials resulting directly from the followed supercritical routes.

Characterization of drug delivery particles produced by supercritical carbon dioxide technologies

2017 ◽  
Vol 128 ◽  
pp. 244-262 ◽  
Author(s):  
Onanong Nuchuchua ◽  
M. Reza Nejadnik ◽  
Sebastiaan C. Goulooze ◽  
Nataša Jovanović Lješković ◽  
Hayley A. Every ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Drug Delivery ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Carbon

Ordered and foam structures of semifluorinated block copolymers in supercritical carbon dioxide

Soft Matter ◽  
2012 ◽  
Vol 8 (21) ◽  
pp. 5811 ◽  
Author(s):  
Tomoaki Shinkai ◽  
Masateru Ito ◽  
Kenji Sugiyama ◽  
Kohzo Ito ◽  
Hideaki Yokoyama
Keyword(s):  
Carbon Dioxide ◽  
Block Copolymers ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Carbon

Thermally robust nanocellular thin films of high-Tg semifluorinated block copolymers foamed with supercritical carbon dioxide

Soft Matter ◽  
2011 ◽  
Vol 7 (8) ◽  
pp. 4032 ◽  
Author(s):  
Rui Zhang ◽  
Cedric Dutriez ◽  
Kenji Sugiyama ◽  
Takashi Ishizone ◽  
Hideaki Yokoyama
Keyword(s):  
Thin Films ◽  
Carbon Dioxide ◽  
Block Copolymers ◽  
Supercritical Carbon Dioxide ◽  
Supercritical Carbon
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