Left Ventricular Diastolic Filling is Impaired by Angiotensin II Even in Subpressor Doses

1994 ◽  
Vol 87 (s31) ◽  
pp. 11P-11P
Author(s):  
Pbm Clarkson ◽  
TM Macdonald ◽  
C Macleod ◽  
NM Wheeldon
Keyword(s):  
Angiotensin Ii ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Left Ventricular Diastolic Filling

Effects of Angiotensin II and Aldosterone on Diastolic Function In Vivo in Normal Man

1994 ◽  
Vol 87 (4) ◽  
pp. 397-401 ◽  
Author(s):  
P. B. M. Clarkson ◽  
N. M. Wheeldon ◽  
C. MacLeod ◽  
M. Tennent ◽  
T. M. MacDonald
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Diastolic Function ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Normal Male ◽  
Normal Man ◽  
Male Subjects ◽  
Left Ventricular Diastolic Filling

1. Doppler echocardiographic indices of diastolic function and systemic haemodynamics were studied in response to infusions of angiotensin II (1, 2, 5 and 10 ng min−1 kg−1), D-aldosterone (2, 4, 10 and 20 ng min−1 kg−1) and placebo [0.9% (w/v) NaCl] in ten normal male subjects. 2. Dose-related increases in systolic and diastolic blood pressure were observed with angiotensin II infusion at rates of 2 ng min−1 kg−1 and above, whereas no changes in blood pressure occurred with D-aldosterone. No changes in aortic stroke distance or heart rate were seen with either angiotensin II or aldosterone infusion. 3. Compared with placebo, angiotensin II infusion produced a dose-related prolongation of the isovolumic relaxation time [mean and 95% confidence intervals 12.0 (8.2–15.8) ms, P < 0.001] at 10 ng min−1 kg−1, and a significant reduction in the ratio between early and late transmitral flow velocity integrals at 2 ng min−1 kg−1, [−0.84 (−1.63 to −0.05), P < 0.05] and 5 ng min−1 kg−1 [−0.76 (−1.47 to −0.05), P < 0.05]. No changes in Doppler echocardiographic indices of diastolic function were observed with D-aldosterone infusion. 4. These data suggest that angiotension II, even at a sub-pressor concentration, produces an impairment of left ventricular diastolic filling, which occurs independently of its effect on aldosterone release.

Right and Left Ventricular Diastolic Filling Parameters in Essential Hypertension

1999 ◽  
Vol 7 (3) ◽  
pp. 214-220 ◽  
Author(s):  
Azad Akkoç ◽  
Berzal Uçaman ◽  
Halil Kaymak ◽  
Ali Vahip Temamoğullari ◽  
Kenan Iltümür ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Left Ventricular Diastolic Filling

Effects of verapamil on left ventricular diastolic filling in children with hypertrophic cardiomyopathy

1988 ◽  
Vol 61 (6) ◽  
pp. 413-417 ◽  
Author(s):  
Elizabeth M. Shaffer ◽  
Albert P. Rocchini ◽  
Robert L. Spicer ◽  
Jack Juni ◽  
Rebecca Snider ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Left Ventricular Diastolic Filling

Relation of Left Ventricular Diastolic Filling to Age and Left Ventricular Hypertrophy

1989 ◽  
Vol 19 (2) ◽  
pp. 283
Author(s):  
Won Kyo Suh ◽  
Chung Whee Choue ◽  
Kwon Sam Kim ◽  
Myung Shick Kim ◽  
Jung Sang Song ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Left Ventricular Diastolic Filling
Sign in / Sign up

Export Citation Format

Share Document