144 Relationship between left atrial spontaneous echo contrast and left ventricular diastolic filling profile in chronic heart failure patients

2003 ◽  
Vol 2 (1) ◽  
pp. 24
Author(s):  
P MASSABUAU ◽  
P HABIB ◽  
J RONCALLI ◽  
J FOURCADE ◽  
A PATHAK ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Left Atrial ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Spontaneous Echo Contrast ◽  
Heart Failure Patients ◽  
Left Ventricular Diastolic Filling

scholarly journals 425 Alterations in left atrial structure and function in chronic heart failure patients with functional mitral regurgitation after MitraClip

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
C Ozturk ◽  
T Fasell ◽  
J M Sinning ◽  
N Werner ◽  
G Nickenig ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Mitral Regurgitation ◽  
Stroke Volume ◽  
Left Atrial ◽  
Left Ventricular ◽  
Functional Mitral Regurgitation ◽  
Heart Team ◽  
Heart Failure Patients ◽  
And Function

Abstract Backround The MitraClip procedure has been increasingly performed as an established treatment alternative for symptomatic patients with moderate to severe mitral regurgitation (MR) at prohibitive surgical risk. Left ventricular (LV) reverse remodelling following MitraClip has been shown in different studies. Left atrial (LA) volumes are believed to decrease following interventional reduction of MR. However, effects of MitraClip on LA function are not well understood. Objectives In this study we aimed to evaluate the effect of MitraClip on LA structure, volumes and function in chronic heart failure patients with functional MR. Methods All patients underwent 3D transthoracic echocardiography prior to the MitraClip procedure and at follow-up (FU) with offline evaluation of LA function and geometry using dedicated software (TomTec Image Arena, 4D LV-Analysis, Munich, Germany). FU examinations were performed 10 ± 3.4 months after the procedure. Results We prospectively included 75 consecutive surgical high risk (Logistic EuroScore: 17.2 ± 13.9%) patients (Age: 77 ± 9years, 22% female) with symptomatic moderate to severe MR without atrial fibrillation. All patients underwent MitraClip following heart team decision without periinterventional major complications. Baseline echocardiography showed impaired left ventricular function (Ejection fraction (EF): 32,6 ± 11.2%), moderate to severe MR , increased systolic right ventricle pressure (RVSP: 46.1 ± 10.5 mmHg) and elevation in estimated left ventricle enddiastolic pressure (E/E´ ratio: 15.6 ± 7.3) in the patient cohort. There was no relevant mitral stenosis after the procedure (MPG: 3.3 ± 0.5 mmHg), however the MPG increased significantly after the procedure (p = 0.05). The E/E´ ratio significantly increased at FU (15.6 ± 7.3, 24.1 ± 13.2, p = 0.05) as well. The left atrial (LA) volumes and LA-muscular mass (End-diastolic volume [LA-EDV] and end-systolic volume [LA-ESV]) significantly increased at FU (LA-EDV: 83.1 ± 39.5ml, 115.1 ± 55.3ml, p = 0.012; LA-ESV: 58.4 ± 33.4ml, 80.1 ± 43.9ml, p = 0.031; 105.1 ± 49.3gr, 145.4 ± 70.6gr, p = 0.013). LA stroke volume significantly increased after the procedure (24.6 ± 12.5ml, 34.9 ± 19.1ml, p = 0.016). LA-EF and atrial global longitudinal strain (LA-GLS) showed no significant changes at FU (LA-EF: 31.7 ± 12.8%, 31.1 ± 12.3%, p= 0.8; LA-GLS: -10.8 ± 5.4%, -9.7 ± 4.45%, p = 0.4). Despite no relevant changes during FU, baseline E/E´ ratio (AUC: 0.652) and baseline aGLS (AUC: 0.694) were found to be independent predictors for mortality. Conclusion Transcatheter MV repair (TMVR) with the MitraClip procedure improves atrial stroke volume, increases atrial volumes and muscular mass acutely after the procedure. It might be explained by the acutely increased MPG and LVEDP after the MitraClip procedure. Baseline aGLS and E/E´ ratio were found to be independent predictors for mortality.

scholarly journals Reversible Restrictive Left Ventricular Diastolic Filling With Optimized Oral Therapy Predicts a More Favorable Prognosis in Patients With Chronic Heart Failure

1998 ◽  
Vol 31 (7) ◽  
pp. 1591-1597 ◽  
Author(s):  
Pier L Temporelli ◽  
Ugo Corrà ◽  
Alessandro Imparato ◽  
Enzo Bosimini ◽  
Francesco Scapellato ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Oral Therapy ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Favorable Prognosis ◽  
Left Ventricular Diastolic Filling

scholarly journals Personalized screening intervals for kidney function in patients with chronic heart failure: a modeling study

2021 ◽  
Author(s):  
Anne-Sophie Schuurman ◽  
Anirudh Tomer ◽  
K. Martijn Akkerhuis ◽  
Ewout J. Hoorn ◽  
Jasper J. Brugts ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Information Gain ◽  
Joint Model ◽  
Left Ventricular ◽  
Individual Risk ◽  
Optimal Time ◽  
Maximum Information ◽  
Heart Failure Patients ◽  
Optimal Time Point

Abstract Background High mortality and rehospitalization rates demonstrate that improving risk assessment in heart failure patients remains challenging. Individual temporal evolution of kidney biomarkers is associated with poor clinical outcome in these patients and hence may carry the potential to move towards a personalized screening approach. Methods In 263 chronic heart failure patients included in the prospective Bio-SHiFT cohort study, glomerular and tubular biomarker measurements were serially obtained according to a pre-scheduled, fixed trimonthly scheme. The primary endpoint (PE) comprised cardiac death, cardiac transplantation, left ventricular assist device implantation or heart failure hospitalization. Personalized scheduling of glomerular and tubular biomarker measurements was compared to fixed scheduling in individual patients by means of a simulation study, based on clinical characteristics of the Bio-SHiFT study. For this purpose, repeated biomarker measurements and the PE were jointly modeled. For personalized scheduling, using this fitted joint model, we determined the optimal time point of the next measurement based on the patient’s individual risk profile as estimated by the joint model and the maximum information gain on the patient’s prognosis. We compared the schedule’s capability of enabling timely intervention before the occurrence of the PE and number of measurements needed. Results As compared to a pre-defined trimonthly scheduling approach, personalized scheduling of glomerular and tubular biomarker measurements showed similar performance with regard to prognostication, but required a median of 0.4–2.7 fewer measurements per year. Conclusion Personalized scheduling is expected to reduce the number of patient visits and healthcare costs. Thus, it may contribute to efficient monitoring of chronic heart failure patients and could provide novel opportunities for timely adaptation of treatment. Graphic abstract

GW24-e1167 Lvosimendan of Chronic Heart Failure Patients With Left Ventricular Systolic Function and VO2MAX

Heart ◽  
2013 ◽  
Vol 99 (Suppl 3) ◽  
pp. A222.3-A223
Author(s):  
Guo Zhi-yong ◽  
Teng Zhi-tao ◽  
Chen Yan ◽  
Zhao Pei-yong
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Ventricular Systolic Function ◽  
Heart Failure Patients
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