Effects of β-Adrenoreceptor Antagonists on Sino-Aortic Baroreflex Sensitivity and Blood Pressure in Hypertensive Man

1979 ◽  
Vol 57 (3) ◽  
pp. 241-247 ◽  
Author(s):  
R. D. S. Watson ◽  
T. J. Stallard ◽  
W. A. Littler
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Older Patients ◽  
Acute Treatment ◽  
Baroreflex Sensitivity ◽  
Chronic Treatment ◽  
Positive Relationship ◽  
Initial Pulse ◽  
Arterial Blood ◽  
Before And After

1. Sensitivity of the sino-aortic baroreflex was investigated before and after acute (23 patients) and chronic (23 patients) β-adrenoreceptor antagonism in patients with essential hypertension. 2. Sensitivity was inversely related to age (r = −0·60) and systolic blood pressure (r = −0·46); a positive relationship was noted between sensitivity and initial pulse intervals (r = 0·40). 3. Sensitivity increased significantly in patients less than 40 years of age after chronic treatment. No change occurred after acute treatment or in older patients treated chronically. 4. The fall in ambulatory intra-arterial blood pressure after chronic treatment was unrelated to alteration of baroreflex sensitivity.

Baroreflex Setting and Sensitivity after Acute and Chronic Nicardipine Therapy

1984 ◽  
Vol 66 (2) ◽  
pp. 233-235 ◽  
Author(s):  
M. A. Young ◽  
R. D. S. Watson ◽  
W. A. Littler
Keyword(s):  
Heart Rate ◽  
Acute Treatment ◽  
Baroreflex Sensitivity ◽  
Chronic Treatment ◽  
Control Mechanism ◽  
Control Period ◽  
Significant Shift ◽  
Baroreflex Control ◽  
Set Point ◽  
Arterial Blood

1. Intra-arterial pressure, baroreflex sensitivity and the baroreflex set point were measured in eight patients with essential hypertension during a control period and then after acute treatment (2 h after a 30 mg oral dose) and after chronic treatment (at least 2 months) with nicardipine hydrochloride, a calcium channel antagonist. 2. Mean intra-arterial blood pressure fell after the acute treatment from 130 ± 14 (sd) control to 118 ± 11 mmHg, P<0.05, and after chronic treatment to 112 ± 19 mmHg, P<0.05. Heart rate increased from 72 ± 11 control to 81 ± 16 beats/min, P<0.05, during acute treatment indicating activation of the baroreflex control mechanism, but returned to control values with chronic treatment (72 ± 11 control vs 69 ± 9 beats/min chronic), indicating a significant shift to the left of the baroreflex set point. There was no change in baroreflex sensitivity after either acute or chronic treatment (control 4.7, acute 4.3, chronic 5.1 ms/mmHg, P not significant for all values). 3. Nicardipine significantly reduces mean intraarterial pressure both acutely and chronically; the latter is associated with a return of the heart rate to control values due to resetting of the baroreflex control mechanism.

Haemodynamic Effects of Noise Exposure before and after β1-Selective and Non-Selective β-Adrenoceptor Blockade in Patients with Essential Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 89s-91s ◽  
Author(s):  
L. Andrén ◽  
L. Hansson ◽  
M. Björkman
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Total Peripheral Resistance ◽  
Noise Exposure ◽  
Blood Pressure Response ◽  
Peripheral Resistance ◽  
Pressure Response ◽  
Arterial Blood ◽  
Before And After ◽  
Haemodynamic Changes

1. Noise stimulation (100 dBA) for 10 min caused a significant increase in diastolic (7.0%, P &lt; 0.001) and mean arterial blood pressure (4.3%, P &lt; 0.01) in patients with essential hypertension. 2. The blood pressure response to noise was due to an increase in total peripheral resistance (4.8%, P &lt; 0.02); heart rate, stroke volume and cardiac output were unchanged. 3. β1-selective adrenoceptor blockade (metoprolol) did not change the haemodynamic reaction pattern induced by noise. 4. Noise exposure during non-selective β-adrenoceptor blockade (propranolol) caused an accentuated blood pressure response with increments of both systolic and diastolic blood pressure as well as a more pronounced rise in total peripheral resistance. 5. The haemodynamic changes induced by noise stimulation at 100 dBA totally disappeared after 5 min of quiet rest at 40 dBA.

Influence of arterial blood pressure and aldosterone on left ventricular hypertrophy in moderate essential hypertension

1993 ◽  
Vol 71 (3) ◽  
pp. A17-A20 ◽  
Author(s):  
Daniel A. Duprez ◽  
Frank R. Bauwens ◽  
Marc L. De Buyzere ◽  
Tine L. De Backer ◽  
Jean M. Kaufman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Arterial Blood Pressure ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Moderate Essential Hypertension ◽  
Arterial Blood

Assessment of the Antihypertensive Effect of Atenolol with 24 H Ambulatory Monitoring of Blood Pressure

1979 ◽  
Vol 57 (s5) ◽  
pp. 387s-389s ◽  
Author(s):  
J. S. Floras ◽  
P. Fox ◽  
M. O. Hassan ◽  
J. V. Jones ◽  
P. Sleight ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Arterial Blood Pressure ◽  
Antihypertensive Effect ◽  
Ambulatory Monitoring ◽  
Single Daily Dose ◽  
Pressure Measurements ◽  
Arterial Blood ◽  
Blood Pressure Study ◽  
Daily Dose

1. Twenty-four hour intra-arterial blood pressure measurements and electrocardiograms were obtained from 12 subjects with untreated essential hypertension. 2. The patients kept records of their activity, paying particular attention to times of retiring to bed, and times of waking in the morning. 3. All subjects were treated with a single daily dose of atenolol (50 to 200 mg) for between 2 and 9 months, and then underwent a second 24 h blood pressure study. 4. Arterial blood pressure was lowered significantly throughout the 24 h period with a single daily dose of atenolol.

Comparative study on effect of neutral spinal bath and neutral spinal spray on blood pressure, heart rate and heart rate variability in healthy volunteers

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Arundhati Goley ◽  
A. Mooventhan ◽  
NK. Manjunath
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Healthy Volunteers ◽  
Group Analysis ◽  
Low Frequency ◽  
Single Session ◽  
Arterial Blood ◽  
Before And After ◽  
Instantaneous Heart Rate

Abstract Background Hydrotherapeutic applications to the head and spine have shown to improve cardiovascular and autonomic functions. There is lack of study reporting the effect of either neutral spinal bath (NSB) or neutral spinal spray (NSS). Hence, the present study was conducted to evaluate and compare the effects of both NSB and NSS in healthy volunteers. Methods Thirty healthy subjects were recruited and randomized into either neutral spinal bath group (NSBG) or neutral spinal spray group (NSSG). A single session of NSB, NSS was given for 15 min to the NSBG and NSSG, respectively. Assessments were taken before and after the interventions. Results Results of this study showed a significant reduction in low-frequency (LF) to high-frequency (HF) (LF/HF) ratio of heart rate variability (HRV) spectrum in NSBG compared with NSSG (p=0.026). Within-group analysis of both NSBG and NSSG showed a significant increase in the mean of the intervals between adjacent QRS complexes or the instantaneous heart rate (HR) (RRI) (p=0.002; p=0.009, respectively), along with a significant reduction in HR (p=0.002; p=0.004, respectively). But, a significant reduction in systolic blood pressure (SBP) (p=0.037) and pulse pressure (PP) (p=0.017) was observed in NSSG, while a significant reduction in diastolic blood pressure (DBP) (p=0.008), mean arterial blood pressure (MAP) (p=0.008) and LF/HF ratio (p=0.041) was observed in NSBG. Conclusion Results of the study suggest that 15 min of both NSB and NSS might be effective in reducing HR and improving HRV. However, NSS is particularly effective in reducing SBP and PP, while NSB is particularly effective in reducing DBP and MAP along with improving sympathovagal balance in healthy volunteers.

Arterial baroreflex sensitivity and blood pressure variabilities before and after carotid surgery

1991 ◽  
Vol 69 (16) ◽  
pp. 763-768 ◽  
Author(s):  
M. Hirschl ◽  
M. M. Hirschl ◽  
D. Magometschnigg ◽  
B. Liebisch ◽  
O. Wagner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Baroreflex Sensitivity ◽  
Carotid Surgery ◽  
Arterial Baroreflex ◽  
Before And After ◽  
Arterial Baroreflex Sensitivity

The Study of Dynamic Response to Acute Hemorrhage by Pulse Spectrum Analysis

2006 ◽  
Vol 34 (03) ◽  
pp. 449-460 ◽  
Author(s):  
Yu Hsin Chang ◽  
Chia I Tsai ◽  
Jaung Geng Lin ◽  
Yue Der Lin ◽  
Tsai Chung Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Steady State ◽  
Arterial Blood Pressure ◽  
Mean Arterial Blood Pressure ◽  
Spectrum Analysis ◽  
Pulse Spectrum ◽  
Acute Hemorrhage ◽  
Arterial Blood ◽  
Percentage Difference ◽  
Before And After

Traditional Chinese Medicine (TCM) holds that Blood and Qi are fundamental substances in the human body for sustaining normal vital activity. The theory of Qi, Blood and Zang-Fu contribute the most important theoretical basis of human physiology in TCM. An animal model using conscious rats was employed in this study to further comprehend how organisms survive during acute hemorrhage by maintaining the functionalities of Qi and Blood through dynamically regulating visceral physiological conditions. Pulse waves of arterial blood pressure before and after the hemorrhage were taken in parallel to pulse spectrum analysis. Percentage differences of mean arterial blood pressure and harmonics were recorded in subsequent 5-minute intervals following the hemorrhage. Data were analyzed using a one-way analysis of variance (ANOVA) with Duncan's test for pairwise comparisons. Results showed that, within 30 minutes following the onset of acute hemorrhage,the reduction of mean arterial blood pressure was improved from 62% to 20%. Throughout the process, changes to the pulse spectrum appeared to result in a new balance over time. The percentage differences of the second and third harmonics, which were related to kidney and spleen, both increased significantly than baseline and towards another steady state. Apart from the steady state resulting from the previous stage, the percentage difference of the 4th harmonic decreased significantly to another steady state. The observed change could be attributed to the induction of functional Qi, and is a result of Qi-Blood balancing activity that organisms hold to survive against acute bleeding.

scholarly journals THE ASSAY OF HYPERTENSIN FROM THE ARTERIAL BLOOD OF NORMOTENSIVE AND HYPERTENSIVE HUMAN BEINGS

1952 ◽  
Vol 95 (6) ◽  
pp. 523-529 ◽  
Author(s):  
Joseph R. Kahn ◽  
Leonard T. Skeggs ◽  
Norman P. Shumway ◽  
Paul E. Wisenbaugh
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Normal Blood ◽  
Moderate Degree ◽  
Human Beings ◽  
Normal Blood Pressure ◽  
Arterial Blood ◽  
The Mean ◽  
Mean Concentration ◽  
Benign Group

Hypertensin has been assayed in the blood of patients with normal blood pressure and in those with essential hypertension in both the benign and malignant phases. 250 ml. samples of arterial blood were obtained, chemically purified, and concentrated to a volume of 1 ml. These extracts were then assayed in anesthetized rats. The concentrations of hypertensin in the blood of patients with the malignant phase of essential hypertension were found to be greatly increased. The concentrations of hypertensin found in patients with benign hypertension had a moderate degree of overlapping with those found in the normotensive group, but the mean concentration of hypertensin in the former group was twice that of the controls. Although these results are statistically significant, the amounts of hypertensin recovered in the benign group are so small that no conclusions can be drawn as to its effectiveness in producing vasoconstriction in these patients.

scholarly journals Stability of the noninvasive baroreflex sensitivity assessment using cross-spectral analysis of heart rate and arterial blood pressure variabilities

2000 ◽  
Vol 23 (3) ◽  
pp. 201-204 ◽  
Author(s):  
Dan Wichterle ◽  
Vojtech Melenovsky ◽  
Lucie Necasova ◽  
Josef Kautzner ◽  
Marek Malik
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Spectral Analysis ◽  
Arterial Blood Pressure ◽  
Baroreflex Sensitivity ◽  
Arterial Blood ◽  
Sensitivity Assessment
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