Measurement of Blood Cortisol and Acid Output in Patients with Duodenal Ulceration and Normal Subjects During Insulin Hypoglycaemia

1985 ◽  
Vol 69 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Anna C. Athow ◽  
Anna T. Sewerniak ◽  
Tina P. Barton ◽  
C. G. Clark ◽  
M. R. Lewin
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Acid ◽  
Acid Output ◽  
Normal Subjects ◽  
Duodenal Ulceration ◽  
Control Subjects ◽  
Healthy Control ◽  
Peak Acid Output ◽  
Pituitary Adrenal Axis ◽  
Stimulation Of

1. The blood cortisol and gastric acid responses to insulin hypoglycaemia were investigated in 18 healthy control subjects and 14 patients with endoscopically proven duodenal ulceration. 2. In both controls and patients, insulin hypoglycaemia caused blood cortisol and acid output to rise and peak simultaneously, the rises being significantly greater in patients with duodenal ulcer than in control subjects. 3. The peak acid output and the base to peak cortisol increments were also found to be significantly greater in patients with duodenal ulcer than in control subjects (P < 0.001 and P < 0.005 respectively). 4. We conclude that insulin hypoglycaemia causes stimulation of the sympathetic and parasympathetic nervous systems and of the hypothalamo-pituitary-adrenal axis, resulting in the simultaneous elevation of gastric juice acidity and blood cortisol levels. We have shown that synchronous rises in gastric acid and blood cortisol occur during insulin hypoglycaemia and that these rises are greater in patients with duodenal ulcer.

What type of vagotomy for duodenal ulcer?

1974 ◽  
Vol 12 (8) ◽  
pp. 29-31
Keyword(s):  
Duodenal Ulcer ◽  
Surgical Treatment ◽  
Gastric Acid ◽  
Social Life ◽  
Acid Output ◽  
Partial Gastrectomy ◽  
Duodenal Ulceration ◽  
Gastric Acid Output ◽  
Duodenal Ulcers

By convention, vagotomy means the division of all or part of the vagus in the abdomen. Gastric acid output falls by 50 – 70% after vagotomy, allowing duodenal ulcers to heal in most patients. Since its introduction in 1943 the operation has been much modified, and has largely replaced partial gastrectomy in the elective surgical treatment of uncomplicated chronic duodenal ulceration. In general, the need for operation is determined by the severity and duration of the symptoms, and the extent to which they interfere with the patient’s work and social life.

The Relation between Functioning Parietal Cell and Gastrin Cell Masses in Two Groups of Duodenal Ulcer Patients

1976 ◽  
Vol 50 (5) ◽  
pp. 375-383 ◽  
Author(s):  
D. J. Byrnes ◽  
Shiu Kum Lam ◽  
W. Sircus
Keyword(s):  
Duodenal Ulcer ◽  
Parietal Cell ◽  
Serum Gastrin ◽  
Acid Output ◽  
Ulcer Patient ◽  
Cell Mass ◽  
Inverse Correlation ◽  
Normal Subjects ◽  
Gastrin Cell ◽  
Before And After

1. Serum gastrin concentrations before and after a standardized meal were determined in twenty-eight patients with duodenal ulcer and in ten normal control subjects. 2. In response to pentagastrin, thirteen of the duodenal ulcer subjects secreted acid within the limits of normal and fifteen secreted in excess. 3. The differences in the basal serum gastrin concentrations between the three groups, normal subjects, acid ‘normosecretors’ and hypersecretors were not statistically significant but that of the hypersecretors was suggestively low. 4. The integrated gastrin response and peak gastrin responses to meals were higher in duodenal ulcer patients with normal acid secretion than in the hypersecretors but the values for the latter were not different from normal subjects. 5. Stabilization of intragastric pH by infusion into the antrum of sodium bicarbonate during the test meal response period did not alter these differences between the two ulcer patient groups. 6. A significant inverse correlation exists between the maximal acid output and the integrated gastrin response in both normal subjects and hypersecreting duodenal ulcer patients. 7. The evidence (a) supports the existence of an inverse relationship between the functioning parietal cell and gastrin cell masses, (b) shows the gastrin response in normosecreting ulcer subjects to be inappropriately high, and (c) suggests that excessive vagotonia exerts trophic effects upon both parietal cell mass and gastrin cell mass.

Investigation of Neuromuscular Transmission in Some Rare Types of Migraine

Cephalalgia ◽  
2007 ◽  
Vol 27 (11) ◽  
pp. 1201-1205 ◽  
Author(s):  
MB Baslo ◽  
A Coban ◽  
B Baykan ◽  
K Tutkavul ◽  
N Karli ◽  
...  
Keyword(s):  
Neuromuscular Transmission ◽  
Primary Headache ◽  
Normal Subjects ◽  
Familial Hemiplegic Migraine ◽  
Single Fibre ◽  
Voluntary Contraction ◽  
Hemiplegic Migraine ◽  
Control Subjects ◽  
Healthy Control ◽  
Patient Groups

The aim of this study was to delineate any dysfunction of neuromuscular transmission (NMT) by single-fibre electromyography (SFEMG) in some rare types of migraine. Recent studies have shown subclinical dysfunction of NMT in migraine with aura and cluster headache by using SFEMG, whereas another recent study has shown NMT to be normal in familial hemiplegic migraine (FHM) with CACNA1A mutations. Thirty patients with rare primary headache syndromes [18 with sporadic hemiplegic migraine (SHM), six with FHM and six with basilar-type migraine (BM)] and 15 healthy control subjects without any headache complaints underwent nerve conduction studies, EMG and SFEMG during voluntary contraction of the extensor digitorum communis muscle. Ten to 20 different potential pairs were recorded and individual jitter values calculated. The results obtained from patient groups were compared with those from the normal subjects. Of 600 individual jitter values of the patients, 27 (4.5%) were abnormally high, whereas only 3/205 (1.5%) jitter values from normal subjects were abnormal. Abnormal NMT was found in 4/30 (13.3%) patients (three SHM and one BM), but in none of the control subjects. Only in SHM patients was the number of individual abnormal jitter values slightly but significantly different from normal controls. The present study demonstrates that subclinical NMT abnormality is slightly present in only SHM and BM patients, but not in FHM patients.

Gastric acid output, bacterial load and gastritis in Helicobacter pylori positive patients with duodenal ulcer

1995 ◽  
Vol 108 (4) ◽  
pp. A147
Author(s):  
PH Le Roux ◽  
AW Harris ◽  
MM Walker ◽  
JJ Misiewicz ◽  
JH Baron
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Gastric Acid ◽  
Acid Output ◽  
Bacterial Load ◽  
Gastric Acid Output

Acupuncture and Gastric Acid Studies

1979 ◽  
Vol 07 (04) ◽  
pp. 356-361 ◽  
Author(s):  
Joseph O. A. Sodipo ◽  
J. M. Falaiye
Keyword(s):  
Duodenal Ulcer ◽  
Pain Relief ◽  
Gastric Acid ◽  
Acid Output ◽  
Symptomatic Relief ◽  
Ulcer Group ◽  
History Of ◽  
Basal Acid ◽  
The Mean ◽  
The Difference

The effects of therapeutic acupuncture on gastric acid secretion on pain relief in chronic duodenal ulcer patients were studied. Ten adult Nigerian patients with clinical, endoscopic as well as radiological evidence of duodenal ulcer constituted the "Ulcer Group". Four other patients who gave history of dyspepsia formed the "Dyspeptic Group". Pentagastrin stimulation test was performed on all subjects pre- and post-acupuncture therapy. The classical Chinese acupuncture loci were employed. The mean Basal Acid Output (BAO) in the duodenal ulcer group was markedly reduced from 4.04 ±1.01 mMols/hour to 1.05±2.5mMols/hour. The mean Maximal Acid Output (MAO) was lowered from 34.72±13.81 mMols/hour to 15.34±4.01 mMols/hour. The difference was statistically significant (P<0.001). It is more probable, therefore, that the relief of pain is attributable to the therapeutic inhibition of gastric hyperacidity in our patients. Thus, though pain relief has been previously demonstrated in response to acupuncture, the results of this investigation have gone further to show that acupuncture achieves symptomatic relief through therapeutic gastric depression in duodenal ulcer patients.

The Effect of Acute Emotional Stress on Gastric Acid Secretion in Normal Subjects and Duodenal Ulcer Patients

1993 ◽  
Vol 17 (2) ◽  
pp. 117-122 ◽  
Author(s):  
William H. Bresnick ◽  
Christian Rask-Madsen ◽  
Daniel L. Hogan ◽  
Michael A. Koss ◽  
Jon I. Isenberg
Keyword(s):  
Duodenal Ulcer ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Emotional Stress ◽  
Normal Subjects ◽  
Acute Emotional Stress
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