Increased Serum Creatine Kinase Activity Inadequately Reflects Exercise-Induced Muscle Damage in Rats

The purpose of this study was to verify the possible appearance in the blood of bradykinin (BK) and des-Arg9-bradykinin (des-Arg9-BK) after eccentric exercise in 13 male subjects. Eccentric exercise (5 × 10 leg presses at 120% maximal voluntary concentric contraction) resulted in muscle damage and inflammation, as suggested by the significant increase in serum creatine kinase activity (from 204 ± 41 to 322 ± 63 U/l 12 h postexercise) and by severe lasting pain, which also peaked at 12 h postexercise. Blood BK and des-Arg9-BK concentrations were measured by competitive enzyme immunoassays using highly specific polyclonal rabbit IgG. Des-Arg9-BK concentration was not modified (preexercise: 44 ± 14 pmol/l; pooled postexercise: 47 ± 4 pmol/l). In contrast, BK concentration significantly increased immediately after the exercise session (68 ± 9 vs. 42 ± 3 pmol/l preexercise) and returned to basal values at 12, 24, and 48 h (pooled value: 40 ± 4 pmol/l). This observation suggests that the inflammatory process due to eccentric exercise-induced muscle damage could be mediated in part by BK.

Download Full-text

Myocardial infarction during a football game: Empiric estimation of the contribution of skeletal muscle damage to the serum creatine kinase activity

Clinical Cardiology ◽

10.1002/clc.4960130810 ◽

1990 ◽

Vol 13 (8) ◽

pp. 566-569

Author(s):

P. P. Studer ◽

C. Bachmann ◽

M. Gertsch ◽

E. Peheim ◽

M. Stäubli

Keyword(s):

Myocardial Infarction ◽

Skeletal Muscle ◽

Creatine Kinase ◽

Muscle Damage ◽

Kinase Activity ◽

Creatine Kinase Activity ◽

Serum Creatine Kinase ◽

Skeletal Muscle Damage ◽

Football Game

Download Full-text

Effects of Acupuncture on Exercise-Induced Muscle Soreness and Serum Creatine Kinase Activity

The American Journal of Chinese Medicine ◽

10.1142/s0192415x99000343 ◽

1999 ◽

Vol 27 (03n04) ◽

pp. 299-305 ◽

Cited By ~ 15

Author(s):

Jaung-Geng Lin ◽

Shao-Hui Yang

Keyword(s):

Creatine Kinase ◽

Muscle Soreness ◽

Kinase Activity ◽

Treated Group ◽

Creatine Kinase Activity ◽

Serum Creatine Kinase ◽

Control Group ◽

Exercise Induced ◽

Male Subjects ◽

Experimental Group

The purpose of this study was to determine the effects of acupuncture on delayed onset muscle soreness (DOMS) produced by exercise. Baseline data were collected on 20 male subjects for intensity of muscle soreness and serum creatine kinase (CK) activity. All values were subsequently reassessed 24, 48 and 72 hours after exercise. The experimental group received acupuncture treatment while the control group received no treatment. Muscle soreness perception was significantly less (P < 0.05) at 72 hours in the acupuncture treated group compared to control group. However, the change in CK was not significantly different between groups. These results suggest that acupuncture is effective in decreasing muscle soreness but does not prevent CK release from muscle.

Download Full-text