DNA polymorphism in the chicken growth hormone gene: Association with egg production

2003 ◽  
Vol 74 (3) ◽  
pp. 243-244 ◽  
Author(s):  
Norio KANSAKU ◽  
Asako NAKADA ◽  
Hisato OKABAYASHI ◽  
Daniel GUEMENE ◽  
Urs KUHNLEIN ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Egg Production ◽  
Dna Polymorphism ◽  
Growth Hormone Gene ◽  
Gene Association

scholarly journals Polymorphisms of Growth Hormone Gene in a Native Chicken Population: Association with Egg Production

2013 ◽  
Vol 57 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Samaneh Gorji Makhsous ◽  
Seyed Ziaeddin Mirhoseini ◽  
Mohammad Javad Zamiri ◽  
Ali Niazi
Keyword(s):  
Growth Hormone ◽  
Egg Production ◽  
Marker Locus ◽  
Growth Hormone Gene ◽  
Chicken Population ◽  
Native Chicken ◽  
Pcr Products ◽  
Breeding Programmes ◽  
Hardy Weinberg Equilibrium ◽  
The Relationship

Abstract A total of 142 chicken blood samples were collected and a specific primer set was used to amplify a fragment of growth hormone locus using PCR. PCR products were digested with SacI and MspI restriction endonucleases. The amplified fragment digested with SacI enzyme revealed two “+” (wild type) and “-” (normal type) alleles with the frequency of 0.898 and 0.102, respectively. The amplified fragment digested with MspI enzyme revealed three A, B and C alleles with the frequency of 0.599, 0.102, and 0.299, respectively. Frequencies of +/+, +/- and -/- were 0.817, 0.162, and 0.021, respectively, and those of AA, AB, AC, BB, BC, and CC were 0.338, 0.113, 0.409, 0.007, 0.070, and 0.063, respectively, in the studied population. The results of 2 and likelihood ratio tests showed that this population was at Hardy-Weinberg equilibrium with respect to the marker locus. Marker-trait association analysis revealed statistically significant differences between “SacI-RFLP” genotypes for egg production and rate of laying eggs. The relationship between the molecular marker and these traits can be useful to improve the chicken breeding programmes.

scholarly journals The human growth hormone gene contains both positive and negative control elements.

1988 ◽  
Vol 263 (11) ◽  
pp. 5005-5007 ◽  
Author(s):  
L N Peritz ◽  
E J Fodor ◽  
D W Silversides ◽  
P A Cattini ◽  
J D Baxter ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Negative Control ◽  
Growth Hormone Gene ◽  
Human Growth Hormone Gene

scholarly journals Allelic Variants in Established Hypopituitarism Genes Expand Our Knowledge of the Phenotypic Spectrum

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1128
Author(s):  
Marilena Nakaguma ◽  
Nathalia Garcia Bianchi Pereira Ferreira ◽  
Anna Flavia Figueredo Benedetti ◽  
Mariana Cotarelli Madi ◽  
Juliana Moreira Silva ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Male Patient ◽  
Missense Variant ◽  
Hormone Deficiency ◽  
Pituitary Hormone ◽  
Incomplete Penetrance ◽  
Growth Hormone Gene ◽  
Posterior Lobe ◽  
Allelic Variants ◽  
Phenotypic Spectrum

We report four allelic variants (three novel) in three genes previously established as causal for hypopituitarism or related disorders. A novel homozygous variant in the growth hormone gene, GH1 c.171delT (p.Phe 57Leufs*43), was found in a male patient with severe isolated growth hormone deficiency (IGHD) born to consanguineous parents. A hemizygous SOX3 allelic variant (p.Met304Ile) was found in a male patient with IGHD and hypoplastic anterior pituitary. YASARA, a tool to evaluate protein stability, suggests that p.Met304Ile destabilizes the SOX3 protein (ΔΔG = 2.49 kcal/mol). A rare, heterozygous missense variant in the TALE homeobox protein gene, TGIF1 (c.268C>T:p.Arg90Cys) was found in a patient with combined pituitary hormone deficiency (CPHD), diabetes insipidus, and syndromic features of holoprosencephaly (HPE). This variant was previously reported in a patient with severe holoprosencephaly and shown to affect TGIF1 function. A novel heterozygous TGIF1 variant (c.82T>C:p.Ser28Pro) was identified in a patient with CPHD, pituitary aplasia and ectopic posterior lobe. Both TGIF1 variants have an autosomal dominant pattern of inheritance with incomplete penetrance. In conclusion, we have found allelic variants in three genes in hypopituitarism patients. We discuss these variants and associated patient phenotypes in relation to previously reported variants in these genes, expanding our knowledge of the phenotypic spectrum in patient populations.

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