Serum S-100 protein: a potentially useful prognostic marker in cutaneous melanoma

ABSTRACTAn 18-year-old female presented with a swelling on the lower lip, which was insidious in onset and gradually progressive. The mass was completely excised under local anaesthesia. Complete histopathologic and immunohistochemical studies were conducted. The Antoni A areas were found along with typical verocay bodies composed of palisading nuclei and surrounding spaces filled with eosinophilic filaments. No necrosis was noted and there were no atypical mitotic figures. In the Antoni B region, a closely textured matrix with areas of edema, myxomatous changes, cystic degeneration and dilated vessels were noted. On the basis of the histopathologic and immunohistochemical staining with S-100 protein, a diagnosis of plexiform schwannoma was made and has been reported in this study. The post-operative view confirmed complete recovery after 6 weeks of surgery. This is a rare case with the tumour located in the lower lip, as very few cases have been reported in literature and it may be the first one reported from India.

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Expression of c-myc oncoprotein represents a new prognostic marker in cutaneous melanoma

British Journal of Surgery ◽

10.1046/j.1365-2168.1998.00528.x ◽

1998 ◽

Vol 85 (1) ◽

pp. 46-51 ◽

Cited By ~ 31

Author(s):

Ross ◽

Wilson

Keyword(s):

Prognostic Marker ◽

Cutaneous Melanoma

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S-100 protein: a prognostic indicator in cutaneous malignant melanoma?

Histopathology ◽

10.1111/j.1365-2559.1987.tb01873.x ◽

1987 ◽

Vol 11 (12) ◽

pp. 1285-1293 ◽

Cited By ~ 12

Author(s):

N.M. KERNOHAN ◽

R. RANKIN

Keyword(s):

Malignant Melanoma ◽

Protein A ◽

Prognostic Indicator ◽

Cutaneous Malignant Melanoma ◽

S 100

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Cellular flip (flice-inhibitory protein), a specific inhibitor of receptor-mediated cell death, is upregulated during cutaneous melanoma development

Journal of Dermatological Science ◽

10.1016/s0923-1811(98)83592-5 ◽

1998 ◽

Vol 16 ◽

pp. S99

Author(s):

R. Bullani ◽

P. Wehrli ◽

I. Viard ◽

J. Tschopp ◽

J.-H. Saurat ◽

...

Keyword(s):

Cell Death ◽

Cutaneous Melanoma ◽

Protein A ◽

Specific Inhibitor ◽

Inhibitory Protein ◽

Cellular Flip

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Immunoelectron microscopic demonstration of S-100b protein-like in centriole, cilia, and basal body.

Journal of Histochemistry & Cytochemistry ◽

10.1177/36.6.3367052 ◽

1988 ◽

Vol 36 (6) ◽

pp. 693-696 ◽

Cited By ~ 21

Author(s):

T Uchida ◽

T Endo

Keyword(s):

Basal Body ◽

Colloidal Gold ◽

Protein A ◽

Ultrastructural Localization ◽

Basal Bodies ◽

Cell Organelles ◽

Gold Particles ◽

Microscopic Demonstration ◽

S 100 ◽

And Function

We report here the ultrastructural localization of S-100b protein-like immunoreactivity in the centriole, cilia, and basal body. Duodenum and trachea of guinea pigs and rats were fixed and immunostained by the protein A-gold method. All centrioles, cilia, and basal bodies observed showed clear S-100b protein-like immunoreactivity. Specific colloidal gold particles were located over the microtubules in these cell organelles. However, other microtubules scattered throughout the cytoplasm were devoid of immunoreactivity. Although the functional significance of S-100b protein-like immunoreactivity in the centriole, cilia, and basal bodies remains to be elucidated, the present results introduce new perspectives into the investigation of localization and function of S-100 proteins.

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