Stratum corneum lipid profile and maturation pattern of corneocytes in the outermost layer of fresh scars: the presence of immature corneocytes plays a much more important role in the barrier dysfunction than do changes in intercellular lipids

2003 ◽  
Vol 149 (4) ◽  
pp. 749-756 ◽  
Author(s):  
T. Kunii ◽  
T. Hirao ◽  
K. Kikuchi ◽  
H. Tagami
Keyword(s):  
Stratum Corneum ◽  
Lipid Profile ◽  
Barrier Dysfunction ◽  
Outermost Layer ◽  
Stratum Corneum Lipid ◽  
Intercellular Lipids

scholarly journals Electron Microscopic Observations of Stratum Corneum Intercellular Lipids in Normal and Atopic Dogs

2001 ◽  
Vol 38 (6) ◽  
pp. 720-723 ◽  
Author(s):  
A. O. Inman ◽  
T. Olivry ◽  
S. M. Dunston ◽  
N. A. Monteiro-Riviere ◽  
H. Gatto
Keyword(s):  
Stratum Corneum ◽  
Transepidermal Water Loss ◽  
Dry Skin ◽  
Electron Microscopic ◽  
Transmission Electron ◽  
Stratum Corneum Lipid ◽  
Structural Differences ◽  
Stratum Corneum Lipids ◽  
Intercellular Lipids ◽  
Intercellular Lipid

The barrier function of mammalian skin is maintained by intercellular stratum corneum lipids. In human patients with atopic dermatitis, an abnormal lipid barrier results in dry skin and increased transepidermal water loss. At this time, it is not known if a defective lipid barrier is present in atopic dogs. Normal and atopic canine skin were postfixed in ruthenium tetroxide and studied using transmission electron microscopy to determine structural differences within stratum corneum lipids. Intercellular lipid lamellae were graded on a semiquantitative scale. The deposition of stratum corneum lipid lamellae in atopic canine skin appeared markedly heterogeneous compared with that seen in normal canine skin. When present, the lamellae often exhibited an abnormal structure. The continuity and thickness of the intercellular lipid lamellae were significantly less in nonlesional atopic than in normal canine skin. These preliminary observations suggest that the epidermal lipid barrier is defective in atopic canine skin. Additional studies are needed to further characterize the biochemical defect and to possibly correct it with nutritional and/or pharmacologic intervention.

Effect of microplasma treatment on stratum corneum lipid molecule

2020 ◽  
Vol 59 (SH) ◽  
pp. SHHF06
Author(s):  
J. Kristof ◽  
T. Aoshima ◽  
M. Blajan ◽  
K. Shimizu
Keyword(s):  
Stratum Corneum ◽  
Lipid Molecule ◽  
Stratum Corneum Lipid

Further investigations on the role of ascorbic acid in stratum corneum lipid models after UV exposure

2005 ◽  
Vol 57 (8) ◽  
pp. 963-972
Author(s):  
Hagen Trommer ◽  
Rolf Böttcher ◽  
Christoph Huschka ◽  
Wolfgang Wohlrab ◽  
Reinhard H. H. Neubert
Keyword(s):  
Ascorbic Acid ◽  
Stratum Corneum ◽  
Uv Exposure ◽  
Stratum Corneum Lipid

Role of Stratum Corneum Lipid Fluidity in Transdermal Drug Flux

1987 ◽  
Vol 76 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Guia M. Golden ◽  
James E. McKie ◽  
Russell O. Potts
Keyword(s):  
Stratum Corneum ◽  
Lipid Fluidity ◽  
Stratum Corneum Lipid ◽  
Drug Flux
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