Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations

2003 ◽  
Vol 120 (6) ◽  
pp. 1062-1065 ◽  
Author(s):  
W. Y. Au ◽  
A. Fung ◽  
C. Man ◽  
S. K. Ma ◽  
T. S. Wan ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukaemia ◽  
Promoter Methylation ◽  
Gene Promoter ◽  
P15 Gene ◽  
Acute Myeloid

scholarly journals Characterisation of the GRAF gene promoter and its methylation in patients with acute myeloid leukaemia and myelodysplastic syndrome

2006 ◽  
Vol 94 (2) ◽  
pp. 323-332 ◽  
Author(s):  
S E Bojesen ◽  
O Ammerpohl ◽  
A Weinhäusl ◽  
O A Haas ◽  
H Mettal ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukaemia ◽  
Gene Promoter ◽  
Acute Myeloid

Microsatellite analysis in acute myeloid leukaemia evolving from myelodysplastic syndrome

2001 ◽  
Vol 112 (1) ◽  
pp. 248-249 ◽  
Author(s):  
Werner Olipitz ◽  
Gernot P. Tilz ◽  
Christine Beham-Schmid ◽  
Christa Eibinger ◽  
Petra Kerzina ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukaemia ◽  
Microsatellite Analysis ◽  
Acute Myeloid

Bone marrow mononuclear cell telomere length in acute myeloid leukaemia and high‐risk myelodysplastic syndrome

2019 ◽  
Vol 102 (3) ◽  
pp. 218-226
Author(s):  
Marie Warny ◽  
Jens Helby ◽  
Henrik Sengeløv ◽  
Børge G. Nordestgaard ◽  
Henrik Birgens ◽  
...  
Keyword(s):  
Bone Marrow ◽  
High Risk ◽  
Acute Myeloid Leukaemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukaemia ◽  
Telomere Length ◽  
Mononuclear Cell ◽  
Bone Marrow Mononuclear Cell ◽  
Acute Myeloid

Myelodysplastic Syndrome, Myeloid Leukaemia of Down Syndrome, and Juvenile Myelomonocytic Leukaemia

2020 ◽  
pp. 134-141
Author(s):  
Henrik Hasle ◽  
Charlotte M. Niemeyer
Keyword(s):  
Bone Marrow ◽  
Down Syndrome ◽  
Stem Cell ◽  
Acute Myeloid Leukaemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukaemia ◽  
Clinical Characteristics ◽  
Bone Marrow Failure ◽  
Signal Pathways ◽  
Acute Myeloid

Myeloid malignancies in children are divided into acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS), juvenile myelomonocytic leukaemia (JMML), and the myeloid leukaemia of Down syndrome (ML-DS). Predisposing genetic conditions are common in MDS. Differentiating MDS from inherited bone marrow failure or AML may be challenging. Therapy consists of observation, immunosuppression, or stem-cell transplantation (SCT). Germline and somatic mutations deregulating the Ras/MAPK signal pathways are key initiating events in JMML. Genetics in JMML defines clinically relevant subgroups and indications for SCT. ML-DS presents with unique clinical characteristics and responds favourably to reduced doses of AML chemotherapy; however, relapse is often refractory to therapy.

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