Low concentrations of intravenous polygelines promote low-molecular weight proteinuria

Summary Geochemical modeling was used to design and conduct a series of alkaline/surfactant/polymer (ASP) coreflood experiments to measure the surfactant retention in limestone cores using sodium hydroxide (NaOH) as the alkali. Surfactant/polymer (SP) coreflood experiments were conducted under the same conditions for comparison. NaOH has been used for ASP floods of sandstones, but these are the first experiments to test it for ASP floods of limestones. Two studies performed under different reservoir conditions showed that NaOH significantly reduced the surfactant retention in Indiana Limestone. An ASP solution with 0.3 wt% NaOH has a pH of approximately 12.6 at 25°C. The high pH increases the negative surface charge of the carbonate, which favors lower adsorption of anionic surfactants. Another advantage of NaOH is that low concentrations of only approximately 0.3 wt% can be used because of its low molecular weight and its low consumption in limestones. Most reservoir carbonates contain gypsum or anhydrite, and therefore sodium carbonate (Na2CO3) will be consumed by the precipitation of calcium carbonate (CaCO3). As shown in the two studies, NaOH can be used in limestone reservoirs containing gypsum or anhydrite.

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Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome

AJP Renal Physiology ◽

10.1152/ajprenal.00095.2007 ◽

2007 ◽

Vol 293 (2) ◽

pp. F456-F467 ◽

Cited By ~ 44

Author(s):

Annalisa Vilasi ◽

Pedro R. Cutillas ◽

Anthony D. Maher ◽

Severine F. M. Zirah ◽

Giovambattista Capasso ◽

...

Keyword(s):

Molecular Weight ◽

Fanconi Syndrome ◽

Low Molecular Weight ◽

Renal Fanconi Syndrome ◽

Dent’S Disease ◽

H Nmr ◽

Low Molecular Weight Proteinuria ◽

Dent's Disease ◽

Underlying Mechanisms ◽

Normal Urine

The renal Fanconi syndrome is a defect of proximal tubular function causing aminoaciduria and low-molecular-weight proteinuria. Dent's disease and Lowe syndrome are defined X-linked forms of Fanconi syndrome; there is also an autosomal dominant idiopathic form (ADIF), phenotypically similar to Dent's disease though its gene defect is still unknown. To assess whether their respective gene products are ultimately involved in a common reabsorptive pathway for proteins and low-molecular-mass endogenous metabolites, we compared renal Fanconi urinary proteomes and metabonomes with normal (control) urine using mass spectrometry and1H-NMR spectroscopy, respectively. Urine from patients with low-molecular-weight proteinuria secondary to ifosfamide treatment (tubular proteinuria; TP) was also analyzed for comparison. All four of the disorders studied had characteristic proteomic and metabonomic profiles. Uromodulin was the most abundant protein in normal urine, whereas Fanconi urine was dominated by albumin.1H-NMR spectroscopic data showed differences in the metabolic profiles of Fanconi urine vs. normal urine, due mainly to aminoaciduria. There were differences in the urinary metabolite and protein compositions between the three genetic forms of Fanconi syndrome: cluster analysis grouped the Lowe and Dent's urinary proteomes and metabonomes together, whereas ADIF and TP clustered together separately. Our findings demonstrate a distinctive “polypeptide and metabolite fingerprint” that can characterize the renal Fanconi syndrome; they also suggest that more subtle and cause-specific differences may exist between the different forms of Fanconi syndrome that might provide novel insights into the underlying mechanisms and cellular pathways affected.

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Japanese Dent disease has a wider clinical spectrum than Dent disease in Europe/USA: genetic and clinical studies of 86 unrelated patients with low-molecular-weight proteinuria

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gft394 ◽

2013 ◽

Vol 29 (2) ◽

pp. 376-384 ◽

Cited By ~ 35

Author(s):

Takashi Sekine ◽

Fusako Komoda ◽

Kenichiro Miura ◽

Junko Takita ◽

Mitsunobu Shimadzu ◽

...

Keyword(s):

Molecular Weight ◽

Clinical Studies ◽

Clinical Spectrum ◽

Dent Disease ◽

Low Molecular Weight ◽

Low Molecular Weight Proteinuria

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Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria

Medical Principles and Practice ◽

10.1159/000490147 ◽

2018 ◽

Vol 27 (4) ◽

pp. 392-395 ◽

Cited By ~ 1

Author(s):

Shpetim Salihu ◽

Katerina Tosheska ◽

Svetlana Cekovska ◽

Velibor Tasic

Keyword(s):

Molecular Weight ◽

Sodium Dodecyl Sulfate ◽

Clinical Presentation ◽

Viral Infections ◽

Sodium Dodecyl ◽

Febrile Illness ◽

Low Molecular Weight ◽

Acute Febrile Illness ◽

Low Molecular Weight Proteinuria ◽

Sds Page

Objective: Febrile proteinuria is functional proteinuria and is seen as a transitory phenomenon during acute febrile illness, mainly viral infections. It is a benign phenomenon and clears promptly with resolution of the infection. Clinical Presentation and Intervention: In this report, we present a patient who was thought to have febrile proteinuria. Persistence of significant proteinuria after resolution of the infection prompted biochemical and genetic workup which led to the diagnosis of Dent-2 disease. Conclusion: We recommend the use of SDS-PAGE (sodium dodecyl sulfate electropheresis) for the detection of low molecular weight proteinuria.

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Hypercalciuria and Nephrocalcinosis in Patients with Idiopathic Low-Molecular-Weight Proteinuria in Japan: Is the Disease Identical to Dent’s Disease in United Kingdom?

Nephron ◽

10.1159/000188464 ◽

1995 ◽

Vol 69 (3) ◽

pp. 242-247 ◽

Cited By ~ 55

Author(s):

Takashi Igarashi ◽

Hiroshi Hayakawa ◽

Hiroshi Shiraga ◽

Hidehiko Kawato ◽

Kunimasa Yan ◽

...

Keyword(s):

Molecular Weight ◽

United Kingdom ◽

Low Molecular Weight ◽

Dent’S Disease ◽

Low Molecular Weight Proteinuria ◽

Dent's Disease

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The effect of a Rhizoctonia solani phytotoxin on potatoes

Canadian Journal of Botany ◽

10.1139/b76-272 ◽

1976 ◽

Vol 54 (22) ◽

pp. 2536-2540 ◽

Cited By ~ 17

Author(s):

J. A. Frank ◽

S. K. Francis

Keyword(s):

Molecular Weight ◽

Growth Hormone ◽

Rhizoctonia Solani ◽

Liquid Culture ◽

Phenylacetic Acid ◽

Low Molecular Weight ◽

Leaf Margin ◽

Disease Symptoms ◽

Low Concentrations ◽

Root Necrosis

Rhizoctonia solani produces a nonenzymatic, low-molecular-weight phytotoxin in liquid culture. Many of the disease symptoms on potato attributed to this pathogen can be induced with this toxin. These include root necrosis and stolon pruning, leaf curling, stunting, and leaf margin chlorosis. In cases of extreme susceptibility, the plants could be killed within 1 week. The toxin has similar effects on radish, beet, and corn seedlings and acts as a growth hormone in low concentrations. A technique was designed to evaluate potato clones for their resistance to the root necrosis phase of the disease syndrome. With additional purification, the toxic fraction was identified as phenylacetic acid and its metahydroxylated derivative.

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