Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease

1996 ◽  
Vol 28 (1) ◽  
pp. 1-13 ◽  
Author(s):  
S.C. BISCHOFF ◽  
J. WEDEMEYER ◽  
A. HERRMANN ◽  
P.N. MEIER ◽  
C. TRAUTWEIN ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cells ◽  
Bowel Disease ◽  
Quantitative Assessment ◽  
Inflammatory Bowel

scholarly journals Mast Cells as Targets for the Therapy of Inflammatory Bowel Disease

1990 ◽  
Vol 4 (7) ◽  
pp. 285-288
Author(s):  
EY Bissonnette ◽  
RC Benyon ◽  
AD Befus
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cell ◽  
Mast Cells ◽  
Bowel Disease ◽  
Inflammatory Responses ◽  
Therapeutic Interventions ◽  
Cell Hyperplasia ◽  
Beneficial Effects ◽  
Inflammatory Bowel ◽  
Multiple Drugs

The etiology and pathogenesis of inflammatory bowel disease (IBD) is poorly understood. However, numerous studies have demonstrated that immunological and inflammatory responses are activated during this disease. A better understanding of these events will help identify appropriate therapeutic interventions. Mast cell hyperplasia is a prominent feature of inflamed intestinal tissue in IBD. Intestinal mast cells are heterogeneous and at least two populations are present in the human intestine. The authors' objective is to explore mast cell properties, activation and mediators that are involved in the induction, maintenance and perpetuation of inflammatory lesions in the intestine. Although some therapies used in IBD can modulate mast cell activities, whether these actions are important in the beneficial effects of the drugs is unknown. Future drug development targeted to the inhibition of mast cells might be of therapeutic value. However, a cascade of different cellular events are involved in IBD development. The complexity of the disease raises difficulties in the development of therapies. Multiple drugs, selective for different phases of the disease or acting on different cells, might be most appropriate, rather than a single, all-encompassing therapeutic agent.

scholarly journals Mucosal Mast Cells in Irritable Bowel Syndrome and Inflammatory Bowel Disease

2005 ◽  
Vol 48 (3-4) ◽  
pp. 163-164 ◽  
Author(s):  
Bilge Tunc ◽  
Levent Filik ◽  
Engin Altıntas ◽  
Nesrin Turhan ◽  
Aysel Ulker ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Bowel Disease ◽  
Mucosal Mast Cell ◽  
Cell Counts ◽  
Mucosal Mast Cells ◽  
Inflammatory Bowel ◽  
Irritable Bowel

Even though exciting progresses have been until now, further studies are necessary to clearly understand the significance of MMC. Mast cells are thought to participate in the pathogenesis of inflammatory bowel disease and irritable bowel syndrome. However, their role in the pathogenesis remains unsettled. The specific aims of this study were to (1) examine mucosal mast cell counts in the cecum in patient with IBS, and IBD (2) compare MMC between the disease groups. We showed increased MMC count in IBS.

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