Expression of metastasis suppressor gene product, nm23 protein, is not inversely correlated with the tumour progression in human malignant melanomas

1996 ◽  
Vol 29 (6) ◽  
pp. 497-505 ◽  
Author(s):  
K. SAITOH ◽  
H. TAKAHASHI ◽  
M. YAMAMOTO ◽  
H. KISHI ◽  
P.G. PARSONS
Keyword(s):  
Gene Product ◽  
Tumour Progression ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene ◽  
Malignant Melanomas ◽  
Nm23 Protein

scholarly journals Regulation of tumor metastasis suppressor gene product, nm 23/nucleoside diphosphate kinase.

1996 ◽  
Vol 71 ◽  
pp. 75
Author(s):  
Jun Mukai ◽  
Satoshi Shiojima ◽  
Yasuhito Shimada ◽  
Hiroshi Ohashi. ◽  
Satoshi Matsushima ◽  
...  
Keyword(s):  
Gene Product ◽  
Tumor Metastasis ◽  
Nucleoside Diphosphate Kinase ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

Expression of the nm23 metastasis-suppressor gene product in skin tumors

1997 ◽  
Vol 24 (3) ◽  
pp. 151-156 ◽  
Author(s):  
Jean Kanitakis ◽  
Sylvie Euvrard ◽  
Dominique Bourchany ◽  
Michel Faure ◽  
Alain Claudy
Keyword(s):  
Gene Product ◽  
Suppressor Gene ◽  
Skin Tumors ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

scholarly journals Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases

Oncogene ◽  
2003 ◽  
Vol 22 (30) ◽  
pp. 4617-4626 ◽  
Author(s):  
Takahisa Takino ◽  
Naohiko Koshikawa ◽  
Hisashi Miyamori ◽  
Motohiro Tanaka ◽  
Takuma Sasaki ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Gene Product ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

EP300-A miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas

2009 ◽  
Vol 126 (1) ◽  
pp. 114-124 ◽  
Author(s):  
Soeren Torge Mees ◽  
Wolf Arif Mardin ◽  
Claudia Wendel ◽  
Nicole Baeumer ◽  
Edith Willscher ◽  
...  
Keyword(s):  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene

scholarly journals Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Qian Zhang ◽  
Jin-yan Wang ◽  
Wei Yan ◽  
Dan-dan Wang ◽  
Su-jin Yang ◽  
...  
Keyword(s):  
Tumor Metastasis ◽  
Therapeutic Strategy ◽  
Malignant Tumors ◽  
Homo Sapiens ◽  
Suppressor Gene ◽  
Metastasis Suppressor ◽  
Metastasis Suppressor Gene ◽  
Ceramide Synthase ◽  
Invasion And Metastasis ◽  
Human Cancers

Abstract Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. The pathological processes and molecular pathways regulated by CerS-2 were also summarized.

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