Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers
Keyword(s):
Abstract Homo sapiens ceramide synthase 2 (CerS-2) plays an important role in inhibiting invasion and metastasis of tumor cells and has been reported as a tumor metastasis suppressor gene in diverse cancers. Thus, low level of CerS-2 protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors. In this review, we discussed the expression, as well as the clinical and pathological significance of CerS-2 in diverse human cancers. The pathological processes and molecular pathways regulated by CerS-2 were also summarized.
2010 ◽
Vol 1
(3)
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pp. 219-230
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2012 ◽
Vol 113
(7)
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pp. 2356-2363
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2004 ◽
Vol 23
(5)
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pp. 318-325
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2006 ◽
Vol 66
(24)
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pp. 11983-11990
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