Galectin-3, a marker of well-differentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia

Abstract Background: Most patients with well differentiated thyroid carcinoma (WDTC) have a favorable prognosis but often report lower health care related quality of life (HRQoL). Sleep quality is one contributor to HRQoL that has also been reported to be impaired in WDTC patients. We evaluated patient reported outcome measures (PROM) of HRQoL and sleep quality in patients with WDTC, and compared them to patients with thyroid nodules. Methods: This is a single institution cohort study utilizing data on consented adult patients with WDTC or thyroid nodules from an integrated cancer research database. We included participants with WDTC and thyroid nodules who completed the SF-36v2 HRQoL survey and the Pittsburgh Sleep Quality Index (PSQI). HRQoL was reported as a composite mental (MCS) and physical (PCS) component score that was compared with population-based norms and reported as the frequency of patients scoring below or well below the age-controlled reference population. Sleep quality was reported as PSQI raw score. Poor sleep quality was defined as a PSQI score >5. Cancer stage was calculated as American Joint Commission on Cancer (AJCC) 7th and 8th edition for each subject in the registry. Results: We evaluated 727 patients and 424 (58%) had WDTC: 219 (72%) with papillary thyroid carcinoma (PTC), 28 (9%) with follicular variant of PTC, 53 (18%) with follicular thyroid carcinoma and 3 (1%) with Hurthle cell carcinoma. Of these, 208 (68.7%) were treated with radioactive iodine ablation with a mean cumulative dose of 197.7 (range 29-700) mCi. Mean age for WDTC was 42.7 years (standard deviation SD 15.4), and 53.4 years (SD 14.3) for nodules (p < 0.001). Eighty one percent of WDTC and 368 (87%) of nodules were female (p = 0.022). PSQI indicated worse sleep quality for WDTC patients with a mean of 6.85 (SD 3.97) and 174 (57.4%) reporting poor sleep quality with a PSQI > 5, compared with a mean score of 6.8 (SD 4.05) and 170 (40.1%) with PSQI > 5 for nodules (p < 0.001). WDTC diagnosis was associated with poor sleep quality with an odds ratio of 2.02 (95% confidence interval 1.48 - 2.75), p < 0.001. Poor quality sleep was also associated with WDTC stage using AJCC8 (0.017) but not AJCC7 (p = 0.067). Overall PCS, MCS, and HRQoL category were not significantly different between WDTC and nodule groups. When stratified by stage, MCS was inversely associated with cancer stage using AJCC7 (p = 0.035) but not AJCC8 (p = 0.96); PCS was associated with cancer stage using both AJCC7 (p = 0.003) and AJCC8 (p < 0.001). Conclusions: Patients with WDTC report worse sleep quality than those with thyroid nodules and it is correlated with AJCC8 stage. HRQoL is similar between all WDTC patients and those with thyroid nodules in this cohort, though WDTC patients with higher stage reported worse physical function. The AJCC 8th was more sensitive to differences in sleep quality and physical function by stage than AJCC 7th.

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RESULTS OF RESEARCH OF GALECTIN-3 AND THYROGLOBULIN IN PATIENTS WITH THYROID NODULES

Grekov s Bulletin of Surgery ◽

10.24884/0042-4625-2015-174-2-81-83 ◽

2015 ◽

Vol 174 (2) ◽

pp. 81-83

Author(s):

O. S. Olifirova ◽

S. V. Knalyan

Keyword(s):

Thyroid Gland ◽

Thyroid Carcinoma ◽

Fine Needle Aspiration ◽

Thyroid Nodules ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Differentiated Thyroid Carcinoma ◽

Fine Needle ◽

Galectin 3 ◽

Benign Nodules

An investigation of galectin-3 and thyroglobulin using IFA was conducted in 80 patients. A lavage of aspirate from the thyroid gland was obtained by fine-needle aspiration biopsy. It was stated that significant increase of galectin-3 and thyroglobulin was noted in case of high differentiated thyroid carcinoma in comparison with benign nodules. Galectin-3 and thyroglobulin from the lavage of thyroid gland aspirate could be used as an oncological marker for complex differentiated diagnostics of high differentiated thyroid carcinoma and benign nodules.

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Lymph node metastases location (central vs lateral neck) in well-differentiated thyroid carcinoma: Is it important?

Endocrine Abstracts ◽

10.1530/endoabs.49.ep1463 ◽

2017 ◽

Author(s):

Bernardo Marques ◽

Raquel Martins ◽

Joana Couto ◽

Jacinta Santos ◽

Teresa Martins ◽

...

Keyword(s):

Lymph Node ◽

Thyroid Carcinoma ◽

Lymph Node Metastases ◽

Differentiated Thyroid Carcinoma ◽

Lateral Neck ◽

Node Metastases ◽

Well Differentiated

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Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature

BMC Endocrine Disorders ◽

10.1186/s12902-021-00724-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Nadia De Falco ◽

Giuseppe Santangelo ◽

Fabrizio Chirico ◽

Angelo Cangiano ◽

Maria Giulia Sommella ◽

...

Keyword(s):

Literature Review ◽

Thyroid Carcinoma ◽

Papillary Carcinoma ◽

Parathyroid Carcinoma ◽

Malignant Tumors ◽

Gamma Probe ◽

Differentiated Thyroid Carcinoma ◽

Thyroid Carcinomas ◽

First Case ◽

Well Differentiated

Abstract Background Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. The intrathyroidal localization of a parathyroid gland is not frequent with a reported prevalence of 0.2%. Carcinoma of parathyroids with intrathyroidal localization represents an even rarer finding, reported in only 16 cases described in literature. The rare constellation of synchronous parathyroid and thyroid carcinomas has prompted us to report our experience and perform literature review. Case presentation We herein report a case of a 63-years-old man with multinodular goiter and biochemical diagnosis of hyperparathyroidism. Total thyroidectomy with radio-guide technique using gamma probe after intraoperative sesta-MIBI administration and intraoperative PTH level was performed. The high radiation levels in the posterior thyroid lobe discovered an intrathyroidal parathyroid. Microscopic examination revealed a parathyroid main cell carcinoma at the posterior thyroidal left basal lobe, a classic papillary carcinoma at the same lobe and follicular variant of papillary carcinoma at the thyroidal right lobe. To the best of our knowledge, this is the first case documenting a synchronous multicentric non medullary thyroid carcinomas and intrathyroidal parathyroid carcinoma. Conclusions Our experience was reported and literature review underlining challenging difficulties in diagnostic workup and surgical management was carried out.

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Prognostic Factors in Patients with Multiple Recurrences of Well-Differentiated Thyroid Carcinoma

Journal of Oncology ◽

10.1155/2009/650340 ◽

2009 ◽

Vol 2009 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Theresa Holler ◽

Jenna Theriault ◽

Richard J. Payne ◽

Jonathan Clark ◽

Spiro Eski ◽

...

Keyword(s):

Prognostic Factors ◽

Thyroid Carcinoma ◽

Univariate Analysis ◽

Mount Sinai Hospital ◽

Differentiated Thyroid Carcinoma ◽

Multiple Treatment ◽

Time To Recurrence ◽

Stage Disease ◽

Well Differentiated ◽

Multiple Recurrences

Introduction.Patients with multiple recurrences of well-differentiated thyroid carcinoma (WDTC) have markedly reduced overall survival when compared with those who have 1 recurrence of their disease. The purpose of this investigation is to identify prognostic factors for mortality in this subgroup.Methods.Patients with multiple recurrences of WDTC were retrospectively identified from the thyroid cancer database at Mount Sinai Hospital, Toronto (1963–2000). Data on patient, tumor, and recurrence characteristics were collected, and each patient was given aMACIS score.Results.A total of 31 patients were identified (11 male, 20 female; 16–83 years). Using univariate analysis, age 45, stage disease, distant metastasis, vascular invasion, MACIS score 6, and time to recurrence of 12 months were found to be significant predictors for mortality in this subgroup.Conclusions.Patients with multiple recurrences of WDTC follow a distinct clinical course, marked with multiple treatment failures and a substantial risk of mortality.

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