Effects of Ageing and Long-Term Hormone Replacement on Cholinergic Neurones in the Medial Septum and Nucleus Basalis Magnocellularis of Ovariectomized Rats

2003 ◽  
Vol 15 (5) ◽  
pp. 477-485 ◽  
Author(s):  
R. B. Gibbs
Keyword(s):  
Hormone Replacement ◽  
Medial Septum ◽  
Nucleus Basalis ◽  
Ovariectomized Rats ◽  
Nucleus Basalis Magnocellularis ◽  
Cholinergic Neurones

Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats

2002 ◽  
Vol 142 (1) ◽  
pp. 52-66 ◽  
Author(s):  
Anna Vale-Martínez ◽  
Gemma Guillazo-Blanch ◽  
Margarita Martí-Nicolovius ◽  
Roser Nadal ◽  
Rosa Arévalo-García ◽  
...  
Keyword(s):  
Active Avoidance ◽  
Ibotenic Acid ◽  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis ◽  
Term Retention ◽  
Long Term Retention

scholarly journals Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats

2017 ◽  
Vol 75 (7) ◽  
pp. 477-483 ◽  
Author(s):  
Maryam Malek ◽  
Alireza Sarkaki ◽  
Saleh Zahedi-Asl ◽  
Yaghoob Farbood ◽  
Ziba Rajaei
Keyword(s):  
Growth Hormone ◽  
Synaptic Plasticity ◽  
Long Term Potentiation ◽  
Nucleus Basalis ◽  
Vehicle Group ◽  
High Frequency Stimulation ◽  
Nucleus Basalis Magnocellularis ◽  
Term Potentiation ◽  
Intrahippocampal Injection

ABSTRACT In this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided into six groups (seven in each) of sham-operated healthy rats (Cont); NBM-lesioned rats (L); NBM-lesioned rats and intrahippocampal injection of growth hormone vehicle (L + Veh); NBM-lesioned and intrahippocampal injection of growth hormone (10, 20 and 40 µg.2 µl-1) (L + GH). In vivo electrophysiological recording techniques were used to characterize maintenance of long-term potentiation at distinct times (1, 2, 3, 24 and 48 hours) after high-frequency stimulation. The population spike was enhanced significantly for about 48 hours following tetanic stimulation in rats treated with a dose-dependent growth hormone compared to the vehicle group (p < 0.05), possibly through neuronal plasticity and neurogenesis in affected areas.

Hippocampal long-term potentiation in nucleus basalis magnocellularis-lesioned rats

1992 ◽  
Vol 29 (6) ◽  
pp. 847-851 ◽  
Author(s):  
C. Frank ◽  
S. Sagratella ◽  
T. Niglio ◽  
M.G. Caporali ◽  
E. Bronzetti ◽  
...  
Keyword(s):  
Long Term Potentiation ◽  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis ◽  
Term Potentiation
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