The Effects of Neonatal Castration on the Subsequent Behavioural Response to Centrally Administered Arginine Vasopressin and the Expression of V1a Receptors in Adult Male Prairie Voles

2003 ◽  
Vol 15 (11) ◽  
pp. 1021-1026 ◽  
Author(s):  
B. S. Cushing ◽  
U. Okorie ◽  
L. J. Young
1999 ◽  
Vol 66 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Gregory E Demas ◽  
Christopher A Moffatt ◽  
Deborah L Drazen ◽  
Randy J Nelson

2021 ◽  
Vol 71 (1) ◽  
Author(s):  
Kenya Sanada ◽  
Mitsuhiro Yoshimura ◽  
Naofumi Ikeda ◽  
Kazuhiko Baba ◽  
Haruki Nishimura ◽  
...  

AbstractWe examined whether the chemogenetic activation of endogenous arginine vasopressin (AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was previously generated. Saline (1 mL/kg) or clozapine-N-oxide (CNO, 1 mg/mL/kg), an agonist for hM3Dq, was subcutaneously administered in adult male AVP-hM3Dq-mCherry transgenic rats (300–370 g). Food and water intake were significantly suppressed after subcutaneous (s.c.) injection of CNO, with aberrant circadian rhythmicity. The percentages of Fos expression in nesfatin-1/NucB2-immunoreactive neurons were significantly increased in the hypothalamus and brainstem at 120 min after s.c. injection of CNO. Suppressed food intake that was induced by chemogenetic activation of endogenous AVP was ablated after intracerebroventricularly administered nesfatin-1/NucB2-neutralizing antibody in comparison with vehicle, without any alteration of water intake nor circadian rhythmicity. These results suggest that chemogenetic activation of endogenous AVP affects, at least in part, central nesfatin-1/NucB2 neurons and may exert anorexigenic effects in the transgenic rats.


2017 ◽  
Vol 8 ◽  
Author(s):  
Trenton C. Simmons ◽  
Jessica F. Balland ◽  
Janeet Dhauna ◽  
Sang Yun Yang ◽  
Jason L. Traina ◽  
...  

2018 ◽  
Vol 67 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Jana Ruda‐Kucerova ◽  
Jana Pistovcakova ◽  
Petra Amchova ◽  
Alexandra Sulcova ◽  
Alena Machalova

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