scholarly journals Ten families of variant genes encoded in subtelomeric regions of multiple chromosomes of Plasmodium chabaudi, a malaria species that undergoes antigenic variation in the laboratory mouse

2003 ◽  
Vol 48 (5) ◽  
pp. 1209-1223 ◽  
Author(s):  
Katja Fischer ◽  
Marina Chavchich ◽  
Robert Huestis ◽  
Danny W. Wilson ◽  
David J. Kemp ◽  
...  
Keyword(s):  
Antigenic Variation ◽  
Laboratory Mouse ◽  
Plasmodium Chabaudi ◽  
Malaria Species ◽  
Variant Genes ◽  
Subtelomeric Regions

Plasmodium berghei and Plasmodium chabaudi chabaudi: development of simple in vitro erythrocyte invasion assays

Parasitology ◽  
1992 ◽  
Vol 105 (3) ◽  
pp. 355-362 ◽  
Author(s):  
J. McNally ◽  
S. M. O'donovan ◽  
J. P. Dalton
Keyword(s):  
Plasmodium Berghei ◽  
Plasmodium Chabaudi ◽  
Rodent Malaria ◽  
Erythrocyte Invasion ◽  
Malaria Species ◽  
Invasion Assays

SUMMARYErythrocyte invasion assays are described for two species of rodent malaria, namely Plasmodium berghei and P. c. chabaudi. These invasion assays are simple, are carried out using a candle jar and allow a number of assays to be performed simultaneously. Our results demonstrate that both rodent malaria species show an in vitro preference for reticulocytes although the preference of P. c. chabaudi for these cells is not as marked as that of P. berghei. The details of our invasion assays and our results obtained are discussed.

Development of irreversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection

Parasitology ◽  
1999 ◽  
Vol 119 (6) ◽  
pp. 543-553 ◽  
Author(s):  
P. N. VUONG ◽  
F. RICHARD ◽  
G. SNOUNOU ◽  
F. COQUELIN ◽  
L. RÉNIA ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Tissue Damage ◽  
Malaria Infection ◽  
Control Measures ◽  
Low Grade ◽  
Plasmodium Chabaudi ◽  
Rodent Malaria ◽  
Pathological Lesions ◽  
Malaria Species ◽  
The Brain

Irreversible pathological lesions were noted in the organs of mice infected with 1 of 3 rodent malaria species: Plasmodium chabaudi chabaudi, P. vinckei petteri and P. yoelii nigeriensis at different times during the course of the primary parasitaemia and long after microscopical clearance of the parasites. Moreover, similar lesions were also obtained when parasite levels were kept below 1%by subcurative drug treatment. The frequency and severity of the lesions correlated with the duration of the infection. Accumulation of tissue damage during chronic low-grade malaria infections has implications for the design of control measures.

Plasmodium chabaudi: Antigenic variation during recrudescent parasitaemias in mice

1982 ◽  
Vol 54 (3) ◽  
pp. 296-302 ◽  
Author(s):  
S.A. McLean ◽  
C.D. Pearson ◽  
R.S. Phillips
Keyword(s):  
Antigenic Variation ◽  
Plasmodium Chabaudi

scholarly journals Telomeric Heterochromatin inPlasmodium falciparum

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Rosaura Hernandez-Rivas ◽  
Karla Pérez-Toledo ◽  
Abril-Marcela Herrera Solorio ◽  
Dulce María Delgadillo ◽  
Miguel Vargas
Keyword(s):  
Plasmodium Falciparum ◽  
Drosophila Melanogaster ◽  
Gene Family ◽  
Histone Modifications ◽  
Chromatin Structure ◽  
Antigenic Variation ◽  
Histone H3 ◽  
Histone H4 ◽  
Telomeric Heterochromatin ◽  
Subtelomeric Regions

Until very recently, little was known about the chromatin structure of the telomeres and subtelomeric regions inPlasmodium falciparum. In yeast andDrosophila melanogaster, chromatin structure has long been known to be an important aspect in the regulation and functioning of these regions. Telomeres and subtelomeric regions are enriched in epigenetic marks that are specific to heterochromatin, such as methylation of lysine 9 of histone H3 and lysine 20 of histone H4. InP. falciparum, histone modifications and the presence of both the heterochromatin “writing” (PfSir2, PKMT) and “reading” (PfHP1) machinery at telomeric and subtelomeric regions indicate that these regions are likely to have heterochromatic structure that is epigenetically regulated. This structure may be important for telomere functions such as the silencing of thevargene family implicated in the cytoadherence and antigenic variation of these parasites.

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