Infective Dose Modulates the Balance between Th1- and Th2-Regulated Immune Responses during Blood-Stage Malaria Infection

1998 ◽  
Vol 48 (5) ◽  
pp. 527-534 ◽  
Author(s):  
TAYLOR-ROBINSON ◽  
PHILLIPS
Keyword(s):  
Immune Responses ◽  
Malaria Infection ◽  
Blood Stage ◽  
Infective Dose ◽  
Blood Stage Malaria ◽  
Th1 And Th2

scholarly journals Lipocalin 2 Bolsters Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection by Reinforcing Host Iron Metabolism

2012 ◽  
Vol 12 (5) ◽  
pp. 705-716 ◽  
Author(s):  
Hong Zhao ◽  
Aki Konishi ◽  
Yukiko Fujita ◽  
Masanori Yagi ◽  
Keiichi Ohata ◽  
...  
Keyword(s):  
Immune Responses ◽  
Iron Metabolism ◽  
Malaria Infection ◽  
Blood Stage ◽  
Lipocalin 2 ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Blood Stage Malaria

Biosynthesized silver nanoparticles protect against hepatic injury induced by murine blood-stage malaria infection

2020 ◽  
Vol 27 (15) ◽  
pp. 17762-17769 ◽  
Author(s):  
Mohamed A. Dkhil ◽  
Rewaida Abdel-Gaber ◽  
Ghada Alojayri ◽  
Esam M. Al-Shaebi ◽  
Mahmood A. A. Qasem ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Malaria Infection ◽  
Hepatic Injury ◽  
Blood Stage ◽  
Blood Stage Malaria

scholarly journals Protection against malaria in mice is induced by blood stage–arresting histamine-releasing factor (HRF)–deficient parasites

2016 ◽  
Vol 213 (8) ◽  
pp. 1419-1428 ◽  
Author(s):  
Claudia Demarta-Gatsi ◽  
Leanna Smith ◽  
Sabine Thiberge ◽  
Roger Peronet ◽  
Pierre-Henri Commere ◽  
...  
Keyword(s):  
Immune Responses ◽  
Plasmodium Berghei ◽  
Blood Cells ◽  
Housekeeping Genes ◽  
Blood Stage ◽  
Parasite Development ◽  
Rodent Models ◽  
Cell Responses ◽  
Blood Stage Malaria

Although most vaccines against blood stage malaria in development today use subunit preparations, live attenuated parasites confer significantly broader and more lasting protection. In recent years, Plasmodium genetically attenuated parasites (GAPs) have been generated in rodent models that cause self-resolving blood stage infections and induce strong protection. All such GAPs generated so far bear mutations in housekeeping genes important for parasite development in red blood cells. In this study, using a Plasmodium berghei model compatible with tracking anti–blood stage immune responses over time, we report a novel blood stage GAP that lacks a secreted factor related to histamine-releasing factor (HRF). Lack of HRF causes an IL-6 increase, which boosts T and B cell responses to resolve infection and leave a cross-stage, cross-species, and lasting immunity. Mutant-induced protection involves a combination of antiparasite IgG2c antibodies and FcγR+ CD11b+ cell phagocytes, especially neutrophils, which are sufficient to confer protection. This immune-boosting GAP highlights an important role of opsonized parasite-mediated phagocytosis, which may be central to protection induced by all self-resolving blood stage GAP infections.

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