Hydrogen exchange of the tetramerization domain of the human tumour suppressor p53 probed by denaturants and temperature

2001 ◽  
Vol 268 (18) ◽  
pp. 4868-4877 ◽  
Author(s):  
José L. Neira ◽  
Mauricio G. Mateu
Keyword(s):  
Hydrogen Exchange ◽  
Tumour Suppressor ◽  
Human Tumour ◽  
Tetramerization Domain ◽  
Tumour Suppressor P53

scholarly journals Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.

2000 ◽  
Vol 47 (2) ◽  
pp. 435-441 ◽  
Author(s):  
A C Asensio ◽  
C R Rodríguez-Ferrer ◽  
S Oaknin ◽  
P Rotllán
Keyword(s):  
Protein A ◽  
Gel Filtration ◽  
Human Platelets ◽  
Tumour Suppressor ◽  
Human Tumour ◽  
Fhit Protein ◽  
Diadenosine Triphosphate

Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.

50 Cross-signaling of activated NF-kappaB and the tumour suppressor p53

2010 ◽  
Vol 8 (5) ◽  
pp. 13
Author(s):  
G. Schneider ◽  
A. Henrich ◽  
V. Wolf ◽  
M. Wieczorek ◽  
S. Reichardt ◽  
...  
Keyword(s):  
Tumour Suppressor ◽  
Nf Kappab ◽  
Tumour Suppressor P53

scholarly journals Tumour suppressor p53 inhibits human fibroblast growth factor 2 expression by a post-transcriptional mechanism

Oncogene ◽  
2001 ◽  
Vol 20 (14) ◽  
pp. 1669-1677 ◽  
Author(s):  
Bruno Galy ◽  
Laurent Créancier ◽  
Catherine Zanibellato ◽  
Anne-Catherine Prats ◽  
Hervé Prats
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Fibroblast ◽  
Tumour Suppressor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Tumour Suppressor P53

scholarly journals In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

2008 ◽  
Vol 15 (6) ◽  
pp. 1019-1029 ◽  
Author(s):  
E M Michalak ◽  
A Villunger ◽  
J M Adams ◽  
A Strasser
Keyword(s):  
Cell Types ◽  
Tumour Suppressor ◽  
Tumour Suppressor P53

scholarly journals The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

Oncogene ◽  
2011 ◽  
Vol 30 (29) ◽  
pp. 3274-3288 ◽  
Author(s):  
G Donati ◽  
S Bertoni ◽  
E Brighenti ◽  
M Vici ◽  
D Treré ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ribosomal Protein ◽  
Mammalian Cells ◽  
Tumour Suppressor ◽  
Ribosomal Protein Synthesis ◽  
Tumour Suppressor P53

scholarly journals A nuclear protein in Schizosaccharomyces pombe with homology to the human tumour suppressor Fhit has decapping activity

2002 ◽  
Vol 46 (1) ◽  
pp. 49-62 ◽  
Author(s):  
Zivar Salehi ◽  
Lars Geffers ◽  
Cristina Vilela ◽  
Ralf Birkenhäger ◽  
Marina Ptushkina ◽  
...  
Keyword(s):  
Schizosaccharomyces Pombe ◽  
Nuclear Protein ◽  
Tumour Suppressor ◽  
Human Tumour

scholarly journals Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein.

1998 ◽  
Vol 79 (4) ◽  
pp. 767-777 ◽  
Author(s):  
S Schaefer ◽  
W H Gerlich ◽  
L Fink ◽  
M Seifer ◽  
S Wenderhold ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Tumour Suppressor ◽  
X Protein ◽  
B Virus ◽  
Tumour Suppressor P53 ◽  
Murine Hepatocyte

scholarly journals Cancer and Tumour Suppressor p53 Encounters at the Juncture of Sex Disparity

2021 ◽  
Vol 12 ◽  
Author(s):  
Sue Haupt ◽  
Ygal Haupt
Keyword(s):  
Tumour Suppressor ◽  
Redox Activity ◽  
Epigenetic Alterations ◽  
Chief Operating Officer ◽  
Protein P53 ◽  
Tumour Suppressor Protein ◽  
Sex Disparities ◽  
Males And Females ◽  
Sex Disparity ◽  
Tumour Suppressor P53

There are many differences in cancer manifestation between men and women. New understanding of the origin of these point to fundamental distinctions in the genetic code and its demise. Tumour suppressor protein p53 is the chief operating officer of cancer defence and critically acts to safeguard against sustained DNA damaged. P53 cannot be ignored in cancer sex disparity. In this review we discuss the greater prevalence and associated death rates for non-reproductive cancers in males. The major tumour suppressor protein p53, encoded in the TP53 gene is our chosen context. It is fitting to ask why somatic TP53 mutation incidence is estimated to be disproportionately higher among males in the population for these types of cancers compared with females? We scrutinised the literature for evidence of predisposing genetic and epigenetic alterations that may explain this sex bias. Our second approach was to explore whether redox activity, either externally imposed or inherent to males and females, may define distinct risks that could contribute to the clear cancer sex disparities.

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