Altered Allelic Distributions of the Serotonin Transporter Gene in Migraine Without Aura and Migraine with Aura

Cephalalgia ◽  
1998 ◽  
Vol 18 (1) ◽  
pp. 23-26 ◽  
Author(s):  
AD Ogilvie ◽  
MB Russell ◽  
P Dhall ◽  
S Battersby ◽  
V Ulrich ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Migraine With Aura ◽  
Migraine Without Aura ◽  
Allelic Variation ◽  
Serotonin Transporter Gene ◽  
Allele Frequency Distribution ◽  
Transporter Gene ◽  
Repeat Allele ◽  
Intron 2 ◽  
Plausible Candidate Gene

Allelic variation of the human serotonin transporter gene (HSERT), a highly plausible candidate gene for susceptibility to migraine, was investigated in 266 individuals with migraine, including 173 having migraine without aura (MO), 94 having migraine with aura (MA), 18 with co-occurrence of MO and MA, plus 133 unaffected controls. The distribution of a polymorphism with different forms of a variable tandem number repeat (VNTR) in intron 2 were compared. The MO group had an over-representation of genotypes with two twelve repeat alleles (STin2.12) and a reduction of genotypes containing one ten repeat (STin2.10) compared to controls. The MA group showed a similar pattern, but also a trend towards an increase in genotypes containing the nine repeat allele of the VNTR (STin2.9). Genotypes containing this allele were found in 6.4% of the MA group compared to 2.3% of controls. The group with co-occurrence of MO and MA had a significantly different pattern of overall allele frequency distribution from controls, reflecting a reduction in genotypes containing the STin2.10 allele and a shift both to STin2.9 carriers and to STin2.12 homozygosity. These results support the view that susceptibility to MO and MA has a genetic component, that these disorders are distinct, and that genetic susceptibility may in some cases be associated with a locus at or near the serotonin transporter gene.

A functional serotonin transporter gene polymorphism is associated with migraine with aura

Neurology ◽  
2005 ◽  
Vol 64 (1) ◽  
pp. 157-159 ◽  
Author(s):  
M. Marziniak ◽  
R. Mossner ◽  
A. Schmitt ◽  
K. P. Lesch ◽  
C. Sommer
Keyword(s):  
Gene Polymorphism ◽  
Serotonin Transporter ◽  
Migraine With Aura ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

Serotonin transporter gene 5-HTTLPR VNTR allele frequency distribution in Africa and Eurasia

2016 ◽  
Vol 6 (2) ◽  
pp. 178-190
Author(s):  
A. S. Gureyev ◽  
A. A. Kim ◽  
Ye. D. Sanina ◽  
V. I. Shirmanov ◽  
V. A. Koshechkin ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Frequency Distribution ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Allele Frequency Distribution ◽  
Transporter Gene

Allelic Variation of Human Serotonin Transporter Gene Expression

2002 ◽  
Vol 66 (6) ◽  
pp. 2621-2624 ◽  
Author(s):  
Armin Heils ◽  
Andreas Teufel ◽  
Susanne Petri ◽  
Gerald Stöber ◽  
Peter Riederer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Serotonin Transporter ◽  
Allelic Variation ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

scholarly journals Serotonin transporter gene 5-HTTLPR VNTR allele frequency distribution in Africa and Eurasia

2014 ◽  
Vol 12 (3) ◽  
pp. 71
Author(s):  
Aleksey Sergeyevich Gureyev ◽  
Anna Aleksandrovna Kim ◽  
Yekaterina Dmitriyevna Sanina ◽  
Vyacheslav Ivanovich Shirmanov ◽  
Vladimir Anatolyevich Koshechkin ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Frequency Distribution ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Allele Frequency Distribution ◽  
Transporter Gene

Bipolar disorder and the serotonin transporter gene: a family-based association study

1999 ◽  
Vol 29 (5) ◽  
pp. 1249-1254 ◽  
Author(s):  
G. KIROV ◽  
M. REES ◽  
I. JONES ◽  
F. MacCANDLESS ◽  
M. J. OWEN ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Serotonin Transporter ◽  
Promoter Region ◽  
Statistical Significance ◽  
Bipolar Affective Disorder ◽  
Serotonin Transporter Gene ◽  
Insertion Polymorphism ◽  
Transporter Gene ◽  
Case Control Studies ◽  
Intron 2

Background. The human serotonin transporter gene (5-HTT) is a strong candidate for involvement in the pathogenesis of mood disorders. Two common polymorphisms have been identified in the gene: a VNTR in intron 2 and a functional deletion/insertion in the promoter region. In previous studies we proposed that allele 12 of the VNTR might increase susceptibility for bipolar disorder.Methods. We have genotyped 122 parent–offspring trios of British Caucasian origin where the proband had DSM-IV Bipolar I disorder (BPI). The results were analysed with the transmission/disequilibrium test (TDT), which examines whether particular alleles are preferentially transmitted from heterozygous parents to affected offspring.Results. The 12 repeat in the VNTR in intron 2 was transmitted 72 times and not transmitted 56 times (χ2 = 2·0, 1 df, P=0·16). If we exclude 24 families in which the proband was a case in our published case–control studies (Collier et al. 1996a; Rees et al. 1997), the excess transmission of allele 12 reaches conventional levels of statistical significance: χ2 = 3·85, 1 df, P<0·05. The deletion/insertion polymorphism in the promoter region was not associated with BPI: 66 parents transmitted the inserted (L) allele and 59 parents transmitted the deleted (S) allele (χ2 = 0·39, 1 df, P=0·53).Conclusions. The 12 repeat of the VNTR in intron 2 of the serotonin transporter gene might be a susceptibility factor in bipolar affective disorder. The genetic effect, if true, is likely to be small, and requires confirmation in further studies using parental controls.

Allelic variation of the serotonin transporter gene polymorphic region in apes

Primates ◽  
2000 ◽  
Vol 41 (3) ◽  
pp. 267-273 ◽  
Author(s):  
Miho Inoue-Murayama ◽  
Youko Niimi ◽  
Osamu Takenaka ◽  
Kyoko Okada ◽  
Ichiyo Matsuzaki ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Allelic Variation ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Region

Polymorphisms within the promoter and the intron 2 of the serotonin transporter gene in a population of bulimic patients

2003 ◽  
Vol 352 (3) ◽  
pp. 226-230 ◽  
Author(s):  
N Lauzurica ◽  
A Hurtado ◽  
A Escartı́ ◽  
M Delgado ◽  
V Barrios ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Intron 2

scholarly journals Looking on the bright side: biased attention and the human serotonin transporter gene

2009 ◽  
Vol 276 (1663) ◽  
pp. 1747-1751 ◽  
Author(s):  
Elaine Fox ◽  
Anna Ridgewell ◽  
Chris Ashwin
Keyword(s):  
Emotional Disorders ◽  
Serotonin Transporter ◽  
Allelic Variation ◽  
Well Being ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Emotional Information ◽  
Processing Bias ◽  
Negative Material ◽  
First Time

Humans differ in terms of biased attention for emotional stimuli and these biases can confer differential resilience and vulnerability to emotional disorders. Selective processing of positive emotional information, for example, is associated with enhanced sociability and well-being while a bias for negative material is associated with neuroticism and anxiety. A tendency to selectively avoid negative material might also be associated with mental health and well-being. The neurobiological mechanisms underlying these cognitive phenotypes are currently unknown. Here we show for the first time that allelic variation in the promotor region of the serotonin transporter gene (5-HTTLPR) is associated with differential biases for positive and negative affective pictures. Individuals homozygous for the long allele (LL) showed a marked bias to selectively process positive affective material alongside selective avoidance of negative affective material. This potentially protective pattern was absent among individuals carrying the short allele (S or SL). Thus, allelic variation on a common genetic polymorphism was associated with the tendency to selectively process positive or negative information. The current study is important in demonstrating a genotype-related alteration in a well-established processing bias, which is a known risk factor in determining both resilience and vulnerability to emotional disorders.

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