P90Growth hormone and insulin- like growth factor 1, in small-for-gestational-age pregnancies with increased pulsatility index in the umbilical artery

Objective To evaluate the impact of serum insulin-like growth factor-1 (IGF-1) levels on cardiac function in small for gestational age (SGA) infants. Study Design This is a prospective, observational study. Serum IGF-1 levels at birth and echocardiography measurements at 1 week of age were compared between SGA and appropriate for gestational age (AGA) infants. Results Thirty-one SGA infants and 27 AGA infants were enrolled. Serum IGF-1 levels were lower in the SGA infants than in the AGA infants. SGA infants had lower mitral lateral annular systolic (S') and early diastolic (E') tissue Doppler imaging velocities compared with AGA infants (S', 5.1 ± 0.9 vs 5.7 ± 1.2 cm/s; E', 6.1 ± 1.5 cm/s vs 7.1 ± 1.3 cm/s; p < 0.05). Serum IGF-1 levels positively correlated with E' velocity in the entire population (r = 0.44, p < 0.001) and in SGA infants (r = 0.39, p < 0.05). In multivariate linear regression analysis, serum IGF-1 and S' velocity were independently associated with E' velocity in the entire population and in SGA infants. Conclusion Decreased serum IGF-I levels could account for cardiac diastolic dysfunction in SGA infants.

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Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational Age

Hormone Research in Paediatrics ◽

10.1159/000502739 ◽

2019 ◽

Vol 92 (1) ◽

pp. 15-27 ◽

Cited By ~ 2

Author(s):

Judith S. Renes ◽

Jaap van Doorn ◽

Anita C.S. Hokken-Koelega

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Gestational Age ◽

Small For Gestational Age ◽

Insulin Like Growth Factor ◽

Short Children ◽

Factor System

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The concentration of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in human umbilical cord serum at delivery: relation to fetal weight

Journal of Endocrinology ◽

10.1677/joe.0.1290459 ◽

1991 ◽

Vol 129 (3) ◽

pp. 459-464 ◽

Cited By ~ 96

Author(s):

H. S. Wang ◽

J. Lim ◽

J. English ◽

L. Irvine ◽

T. Chard

Keyword(s):

Growth Factor ◽

Umbilical Cord ◽

Fetal Growth ◽

Gestational Age ◽

Umbilical Artery ◽

Binding Protein ◽

Insulin Like Growth Factor ◽

Factor Binding ◽

Factor I ◽

Igf I

ABSTRACT Serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-1 (IGFBP-1) have been determined by radioimmunoassay in the maternal circulation (n = 91) and in the umbilical artery (n = 56) and vein (n = 90) of man. In both the umbilical artery and vein, the concentration of serum IGF-I showed an inverse correlation with birthweight (P < 0·005 and P < 0·001 respectively); the mean serum IGF-I levels in the small-for-gestational-age (SGA) group were significantly higher than those in average-for-gestational-age (AGA) neonates (P <0·01 and P < 0·001 respectively). However, maternal serum IGF-I showed no association with birthweight and there was no significant difference between the SGA and AGA groups. These observations imply that the production of IGF-I in the maternal and fetal compartments is independent and that there is unlikely to be transfer of IGF-I across the placenta. Serum IGFBP-1 levels in both maternal and umbilical cord blood (artery and vein) showed an inverse relation to birthweight (P <0·001, P<0·005 and P<0·001 respectively). Increased IGFBP-1 levels in the umbilical artery and vein were observed in the SGA group. These findings suggest that IGFBP-1 might inhibit the action of IGF-I in both the maternal and the fetal compartments and that the rise in IGFBP-1 could be a primary factor in retardation of fetal growth. Alternatively, circulating IGF-I and IGFBP-1 levels may only be a secondary reflection of local tissue events involved in fetal growth. Journal of Endocrinology (1991) 129, 459–464

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Postnatal growth in children born small and appropriate for gestational age during the first years of life

Medicina ◽

10.3390/medicina45010008 ◽

2008 ◽

Vol 45 (1) ◽

pp. 51 ◽

Cited By ~ 2

Author(s):

Margarita Valūnienė ◽

Agnė Danylaitė ◽

Dovilė Kryžiūtė ◽

Giedrė Ramanauskaitė ◽

Danutė Lašienė ◽

...

Keyword(s):

Body Mass Index ◽

Growth Factor ◽

Body Mass ◽

Gestational Age ◽

Small For Gestational Age ◽

Binding Protein ◽

Insulin Like Growth Factor ◽

Appropriate For Gestational Age ◽

Igf Binding ◽

Igf Binding Protein

The aim of the study was to evaluate growth pattern of small- and appropriate-for-gestationalage children and to identify prenatal and postnatal risk factors for short stature and development of components of metabolic syndrome. A total of 109 small- and 239 appropriate-for-gestational-age infants were enrolled in the study. Within 24 hours after birth and at 2, 5, 9, 12, 18, 24 months, and 6 years of age, anthropometric data were recorded for study children. Cord blood samples from study infants were collected, and insulin-like growth factor-1 (IGF), IGF-binding protein-3, and leptin levels were measured. Birth weight and height (P<0.001) and insulin-like growth factor-1, IGF-binding protein-3, and leptin levels (P<0.05) were lower in children born small for gestational age vs. children born appropriate for gestational age. At 2, 5, 12, 18, and 24 months and 6 years of age, children born small for gestational age remained shorter and weighed less (P<0.001). Waist-to-hip ratio, heart rate at 6 years of age and gain in body mass index from birth up to 6 years of age was higher in children born small for gestational age. Height gain during the first year of life was mainly influenced by birth length and target height. Maternal weight before pregnancy and cord leptin levels were the most significant factors influencing postnatal weight gain during the first years of life. Conclusions. During the first 6 years of life, children born small for gestational age remained shorter and lighter. A greater catch-up in body mass index and tendency towards central pattern of fat distribution during the first years of life might be predisposing factors for the development of long-term metabolic complications in these individuals.

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