Galectin-3, a β-Galactoside-Binding Animal Lectin, Binds to Neural Recognition Molecules

2002 ◽  
Vol 64 (6) ◽  
pp. 2465-2472 ◽  
Author(s):  
Rainer Probstmeier ◽  
Dirk Montag ◽  
Melitta Schachner
Keyword(s):  
Galectin 3 ◽  
Animal Lectin

Placental Expression and Relative Role of Anti-inflammatory Annexin A1 and Animal Lectin Galectin-3 in the Pathogenesis of Preeclampsia

2021 ◽  
Author(s):  
Komal Ruikar ◽  
Manjunath Aithal ◽  
Praveenkumar Shetty ◽  
Udupi Shastry Dinesh ◽  
Anil Bargale ◽  
...  
Keyword(s):  
Relative Role ◽  
Annexin A1 ◽  
Galectin 3 ◽  
Anti Inflammatory ◽  
Animal Lectin

scholarly journals Biological Applications of a Chimeric Probe for the Assessment of Galectin-3 Ligands

2007 ◽  
Vol 55 (10) ◽  
pp. 1015-1026 ◽  
Author(s):  
Fabiana H. M. de Melo ◽  
Diego Butera ◽  
Raphael S. Medeiros ◽  
Luciana N. de S. Andrade ◽  
Suely Nonogaki ◽  
...  
Keyword(s):  
Biological Significance ◽  
Inflammatory Cells ◽  
Biological Applications ◽  
Phaseolus Vulgaris L ◽  
Galectin 3 ◽  
Immunoenzymatic Assays ◽  
B Blood Group ◽  
Animal Lectin ◽  
Online Supplemental Material

β1–6 branching of N-linked oligosaccharides has been correlated with the progression of different cancers. The leukoagglutinins of Phaseolus vulgaris (L-PHA) have been used to study this pattern of glycosylation whose biological significance is incompletely understood. The animal lectin, galectin-3, also binds to structures recognized by L-PHA. To develop a functional tool for the in situ identification of this pattern of glycosylation, human galectin-3 was fused to bacterial alkaline phosphatase (gal3/AP). Gal3/AP recognized both A and B blood group saccharides (B>A) and lactosamine derivatives. Gal3/AP recognition depended at least in part on the N-linked oligosaccharides of different glycoproteins. The presence and distribution of galectin-3 ligands were analyzed in both murine and human normal and tumor samples. Loss of apical expression of galectin-3 ligands was commonly found in carcinomas. Endothelial and inflammatory cells were enriched in galectin-3 ligands as compared with tumor cells; thus, gal3/AP is a suitable tool for studying tumor micro-environments. Comparative analysis of both gal3/AP and L-PHA binding patterns indicated that although similar, these patterns are not identical. The probe developed was useful for several immunoenzymatic assays and will allow the physiological and clinical significance of the expression pattern of galectin-3 ligands to be established. This manuscript contains online supplemental material at http:/www.jhc.org . Please visit this article online to view these materials. (J Histochem Cytochem 55: 1015–1026, 2007)

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Hostile attribution is associated with increased galectin-3 in heart failure patients

2013 ◽  
Author(s):  
Wawrzyniak Andrew J. ◽  
Kerry S. Whittaker ◽  
Sarah M. Godoy ◽  
Kristie M. Harris ◽  
Maria N. Banis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hostile Attribution ◽  
Heart Failure Patients ◽  
Galectin 3

Galectin-3 vermindert die akute und chronische DSS-Kolitis bei Mäusen

2008 ◽  
Vol 46 (10) ◽  
Author(s):  
E Lippert ◽  
M Stieber-Gunckel ◽  
C Hofmann ◽  
N Dunger ◽  
W Falk ◽  
...  
Keyword(s):  
Galectin 3

Galectin-3 and Aldosterone as Potential Tandem Biomarkers in Pulmonary Arterial Hypertension

2016 ◽  
Vol 64 (S 02) ◽  
Author(s):  
L. Calvier ◽  
E. Legchenko ◽  
L. Grimm ◽  
H. Sallmon ◽  
A. Hatch ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Galectin 3 ◽  
Pulmonary Arterial

Evaluation der kardialen Biomarker Galectin-3 und ST2 (IL1RL1) bei Patienten mit beginnender degenerativer Mitralklappenerkrankung (CHIEF B)

2019 ◽  
Author(s):  
S. Klein ◽  
I. Nolte ◽  
E.-M. Packeiser ◽  
N. Iwanuk ◽  
K. Rumstedt ◽  
...  
Keyword(s):  
Galectin 3
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