Placental Expression and Relative Role of Anti-inflammatory Annexin A1 and Animal Lectin Galectin-3 in the Pathogenesis of Preeclampsia

2021 ◽  
Author(s):  
Komal Ruikar ◽  
Manjunath Aithal ◽  
Praveenkumar Shetty ◽  
Udupi Shastry Dinesh ◽  
Anil Bargale ◽  
...  
Keyword(s):  
Relative Role ◽  
Annexin A1 ◽  
Galectin 3 ◽  
Anti Inflammatory ◽  
Animal Lectin

scholarly journals Biological and physical approaches on the role of piplartine (piperlongumine) in cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tiago Henrique ◽  
Caroline de F. Zanon ◽  
Ana P. Girol ◽  
Ana Carolina Buzzo Stefanini ◽  
Nayara S. de A. Contessoto ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Therapeutic Potential ◽  
Inhibitory Effect ◽  
Physicochemical Analysis ◽  
Biologically Active ◽  
Migration And Invasion ◽  
Annexin A1 ◽  
Anti Inflammatory ◽  
Mimic Peptide

AbstractChronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression. Piplartine (PL) is a biologically active alkaloid from long peppers that exhibits anti-inflammatory and antitumor activity. In the present study, we investigated the physical and chemical interactions of PL with anti-inflammatory compounds and their effects on cell proliferation and migration and on the gene expression of inflammatory mediators. Molecular docking data and physicochemical analysis suggested that PL shows potential interactions with a peptide of annexin A1 (ANXA1), an endogenous anti-inflammatory mediator with therapeutic potential in cancer. Treatment of neoplastic cells with PL alone or with annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes. The results also suggested an inhibitory effect of PL on tubulin expression. In addition, PL apparently had no influence on cell migration and invasion at the concentration tested. Considering the role of inflammation in the context of promoting tumor initiation, the present study shows the potential of piplartine as a therapeutic immunomodulator for cancer prevention and progression.

scholarly journals Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia

2010 ◽  
Vol 185 (10) ◽  
pp. 6317-6328 ◽  
Author(s):  
Simon McArthur ◽  
Enrico Cristante ◽  
Mario Paterno ◽  
Helen Christian ◽  
Federico Roncaroli ◽  
...  
Keyword(s):  
Annexin A1 ◽  
Anti Inflammatory

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Investigating the role of Annexin A1 in Adipogenesis and its ability to dampen Obesity associated Inflammation

2017 ◽  
Author(s):  
Sehar Sajid ◽  
Derek Renshaw ◽  
Bernard Burke ◽  
Christopher Mee
Keyword(s):  
Annexin A1

Galectin-3 in Heart Failure – Linking Fibrosis, Remodelling and Progression

2010 ◽  
Vol 6 (2) ◽  
pp. 33 ◽  
Author(s):  
Christopher R deFilippi ◽  
G Michael Felker ◽  
◽  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Risk Stratification ◽  
Cardiac Fibrosis ◽  
The Elderly ◽  
Preserved Ejection Fraction ◽  
Heart Failure Patients ◽  
Large Populations ◽  
Galectin 3

For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodelling that represents an intriguing link between inflammation and fibrosis. In this article we review the biology of galectin-3, recent clinical research and its application in the management of heart failure patients.

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