scholarly journals Circadian rhythms in systemic hemodynamics and renal function in healthy subjects and patients with nephrotic syndrome

2001 ◽  
Vol 59 (5) ◽  
pp. 1873-1880 ◽  
Author(s):  
Albertus J. Voogel ◽  
Marion G. Koopman ◽  
Augustinus A.M. Hart ◽  
Gert A. Van Montfrans ◽  
Lambertus Arisz
Keyword(s):  
Renal Function ◽  
Nephrotic Syndrome ◽  
Circadian Rhythms ◽  
Healthy Subjects ◽  
Systemic Hemodynamics

scholarly journals Systemic hemodynamics and renal function in hemorrhaged dogs resuscitated with cross-linked hemoglobin

2000 ◽  
Vol 278 (1) ◽  
pp. R28-R33 ◽  
Author(s):  
John M. Stulak ◽  
Luis A. Juncos ◽  
John A. Haas ◽  
J. Carlos Romero
Keyword(s):  
Nitric Oxide ◽  
Renal Function ◽  
Cardiac Output ◽  
Sodium Excretion ◽  
Systemic Hemodynamics ◽  
Urinary Flow ◽  
Excretory Function ◽  
Renal Function Recovery ◽  
Function Recovery ◽  
Hormonal Milieu

Cross-linked hemoglobin (XL-Hb) infused into dogs increases mean arterial pressure (MAP) but decreases blood flow to the renal (RBF), mesenteric (MBF), and iliac (IBF) circulations. These actions differ markedly from dextran infusion (which increases RBF, MBF, and IBF without altering MAP) and may be due to scavenging of nitric oxide by XL-Hb. However, because the hormonal milieu regulating regional circulation is altered during hemorrhage (when XL-Hb may be used), we studied whether systemic hemodynamics, RBF, MBF, IBF, and renal excretory function in hemorrhaged dogs was altered when resuscitated with XL-Hb compared with dextran ( n = 6 each). Hemorrhage decreased MAP by 25% due to a 75% decline in cardiac output. RBF, MBF, and IBF all fell by 33, 64, and 72%, respectively ( P < 0.05 each). There was also a fall in glomerular filtration rate (GFR), urinary flow, and sodium excretion ( P < 0.05 each). After resuscitation, MAP, cardiac output, RBF, MBF, IBF, and GFR all recovered to basal values with either XL-Hb or dextran. Urinary flow and sodium excretion increased to above basal levels with dextran (both by 3.5-fold; P < 0.05) or XL-Hb (by 7.5- and 10-fold, respectively; P < 0.05). We conclude that resuscitation with XL-Hb after hemorrhage not only increases MAP, but also restores RBF, MBF, IBF, GFR, and urinary sodium and volume excretion analogously to dextran. The results contrast with those in normal dogs and suggest that nitric oxide inhibition does not impair hemodynamic and renal function recovery during hemorrhage.

Thyroid Function in Patients with Nephrotic Syndrome and Normal Renal Function

1982 ◽  
Vol 2 (2) ◽  
pp. 70-76 ◽  
Author(s):  
Eben I. Feinstein ◽  
Elaine M. Kaptein ◽  
John T. Nicoloff ◽  
Shaul G. Massry
Keyword(s):  
Renal Function ◽  
Nephrotic Syndrome ◽  
Thyroid Function ◽  
Normal Renal Function

Impact of Treatment of Dyslipidemia on Renal Function, Fat Deposits and Scarring in Patients with Persistent Nephrotic Syndrome

Nephron ◽  
2002 ◽  
Vol 91 (4) ◽  
pp. 612-619 ◽  
Author(s):  
Osama Ashry Gheith ◽  
Mohamed Abel-Kader Sobh ◽  
Kefaia El-Sayed Mohamed ◽  
Mahmoud Abdo El-Baz ◽  
Fatma El-Husseini ◽  
...  
Keyword(s):  
Renal Function ◽  
Nephrotic Syndrome ◽  
Fat Deposits

scholarly journals Longitudinal Study of the Decline in Renal Function in Healthy Subjects

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129036 ◽  
Author(s):  
Mika Baba ◽  
Takuro Shimbo ◽  
Masaru Horio ◽  
Masahiko Ando ◽  
Yoshinari Yasuda ◽  
...  
Keyword(s):  
Renal Function ◽  
Longitudinal Study ◽  
Healthy Subjects

Hyperaggregability Of Serotonin-Depleted Platelets To Arachidonic Acid (AA) In SLE And Transplant Recipients

1981 ◽  
Author(s):  
D Marchesi ◽  
A Parbtani ◽  
G Frampton ◽  
M Livio ◽  
G Remuzzi ◽  
...  
Keyword(s):  
Renal Function ◽  
Arachidonic Acid ◽  
Nephrotic Syndrome ◽  
Platelet Activation ◽  
Great Majority ◽  
Transplant Recipients ◽  
Renal Microvasculature ◽  
Thrombotic Tendency ◽  
Reduced Renal Function

In a variety of renal disorders, including SLE and transplantation, in vivo platelet activation is present. This is in part a result of the nephrotic syndrome, but is also observed in patients with g.n. who are not nephrotic. As a result, intraplatelet concentrations of serotonin and other amines are depleted in patients with active nephritis. The functional capacity of such amine-depleted platelets has been little studied; Pareti et al (1980) reported defective aggregation to ADP, adrenaline and collagen in such “acquired storage pool deficiencies”. We studied aggregation thresholds to ADP, collagen and AA in 25 patients with SLE nephritis, none of whom had a nephrotic syndrome or reduced renal function. In these patients platelet activation is due principally to circulating factors. Sixteen transplant recipients were also studied. In them, activation is principally within the renal microvasculature of the allograft. We also measured intraplatelet serotonin concentrations, which were low or zero in the great majority of patients in both groups. Bleeding times were normal in all, as were platelet aggregation thresholds to ADP and collagen. AA thresholds, however, were markedly depressed (<0.32 mmol) in all transplant recipients and most patients with SLE. This specific hyperaggregability may be responsible for both persistence of disease and the thrombotic tendency observed in some patients, including those with circulating anticoagulant.

scholarly journals Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects.

1997 ◽  
Vol 41 (7) ◽  
pp. 1562-1565 ◽  
Author(s):  
S C Chien ◽  
A T Chow ◽  
J Natarajan ◽  
R R Williams ◽  
F A Wong ◽  
...  
Keyword(s):  
Renal Function ◽  
Healthy Subjects ◽  
Age Groups ◽  
The Elderly ◽  
Gender Effects ◽  
Pharmacokinetic Parameters ◽  
Age And Gender ◽  
Male And Female ◽  
Young Males ◽  
And Gender

The influence of age and gender on the pharmacokinetics of levofloxacin in healthy subjects receiving a single oral 500-mg dose of levofloxacin was investigated in this parallel design study. Six young males (aged 18 to 40 years), six elderly males (aged > or = 65 years), six young females (aged 18 to 40 years), and six elderly females (aged > or = 65 years) were enrolled and completed the study. The study reveals that the bioavailability (rate and extent) of levofloxacin was not affected by either age or gender. In both age (young and elderly) and gender (male and female) groups of subjects, peak concentrations in plasma were reached at approximately 1.5 h after dosing; renal clearance of levofloxacin accounted for approximately 77% of total body clearance, and approximately 76% of the administered dose was recovered unchanged in urine over the 36 h of collection. The apparent differences in the calculated pharmacokinetic parameters for levofloxacin between the age groups (young versus elderly) and between the gender groups (males versus females) could be explained by differences in renal function among the subjects. A single dose of 500 mg of levofloxacin administered orally to both young and old, male and female healthy subjects was found to be safe and well tolerated. As the differences in levofloxacin kinetics between the young and the elderly or the males and the females are limited and are mainly related to the renal function of the subjects, dose adjustment based on age or gender alone is not necessary.

scholarly journals Radiologically Guided Renal Artery Embolization with an Amplatzer Vascular Plug as a Rescue Therapy for Refractory Nephrotic Syndrome in AL-Amyloidosis

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
I. Spozio Züst ◽  
H. R. Räz ◽  
F. Burkhalter
Keyword(s):  
Renal Function ◽  
Nephrotic Syndrome ◽  
Amplatzer Vascular Plug ◽  
Bleeding Complications ◽  
High Dose ◽  
Al Amyloidosis ◽  
Vascular Plug ◽  
Relevant Effect ◽  
Renal Ablation ◽  
Refractory Nephrotic Syndrome

Nephrotic syndrome is common in immunoglobulin light-chain (AL) amyloidosis and successful therapy may pose a challenge. We report the case of a 63-year-old patient with severe nephrotic syndrome due to primary renal AL-amyloidosis with well-preserved renal function at first presentation. Therapy with high dose steroids, loop diuretics, and ACE-inhibitors did not affect his proteinuria and he was seriously disabled because of symptomatic orthostatic hypotension and anasarca. With the patient’s informed consent, medical nephrectomy was tried with nonsteroidal-anti-inflammatory drugs (NSAIDs), cyclosporine, and aminoglycosides, with significant deterioration of his renal function, but without relevant effect on his proteinuria. Despite adequate anticoagulation life threatening thrombotic and bleeding complications occurred. Total renal ablation was finally achieved using an Amplatzer vascular plug Typ IV (AVP 4) with a self-expanding Nitinol mesh design, which was placed in both main renal arteries in the same intervention. The patient became completely anuric, protein loss stopped, and serum albumin slowly rose to normal levels. The patient’s clinical condition dramatically improved and he regained his full mobility at the price of a lifelong renal replacement therapy. To our knowledge, this is the first reported usage of such a vascular occluder in the setting of refractory nephrotic syndrome with normal kidney function at the time of first presentation.

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