Purpose: To explore the clinical effect of intense pulsed light on freckles. Methods: A total of 102 patients with facial freckles treated in our hospital between November 2014 and May 2017 were taken as the subjects of this study. The patients, after being confirmed with facial freckles, were treated with M22 Photorejuvenation, and evaluated at the end of the treatment in terms of therapeutic effect, adverse reactions, changes of indicators before and after treatment as well as relapse. Results: In terms of treatment effect, there were 46 patients (45.10%) above expectation, 50 patients (49.02%) up to expectation and 6 patients (5.88%) below the standard, with a total effective rate of 94.12%. In terms of adverse reactions, there were 8 patients with temporary facial flushing, 4 patients with mild edema and 3 patients with burning sensation, with a probability of 14.71%. In terms of indicator changes before and after treatment, the skin elasticity and skin moisture of each part of the patient’s face were improved, with the skin elasticity of the patient’s forehead and lower jaw up by 8.9% and 8%, respectively, and the skin moisture of the patient’s left cheek up by 25.7%, which was very obvious. In addition, the proportion of melanin and skin oil of the patients were significantly reduced, with the melanin proportion of the left cheek down by 30.1% and the overall skin oil proportion of the face down by about 1%. At the end of the treatment, 5 patients had freckle recurrence, with a recurrence rate of 4.90%, which was statistically significant (P<0.05). Discussion: The intense pulsed light is an effective tool in the treatment of facial freckles. Despite occasional adverse reactions, multiple indicators of various parts of the patient’s face have been significantly improved, with a low probability of later recurrence, making it worthy of clinical promotion.