The role of compatibility tests. (Report of a meeting sponsored by the Bureau of Biologics for the Blood Products Advisory Committee)

Transfusion ◽  
1982 ◽  
Vol 22 (2) ◽  
pp. 169-172 ◽  
Author(s):  
G Garratty
Keyword(s):  
Advisory Committee ◽  
Blood Products

scholarly journals A review of the use of blood and blood products in HIV-infected patients

2012 ◽  
Vol 13 (2) ◽  
Author(s):  
Karen van den Berg
Keyword(s):  
Transfusion Medicine ◽  
Blood Products ◽  
Ethical Considerations ◽  
Appropriate Use ◽  
Hiv Patients ◽  
Hiv Negative

Despite numerous publications on the appropriate use of blood and blood products, few specifically consider the role of transfusion in the management of HIV. This review is a synthesis of conditions encountered in the management of HIV-infected patients where the transfusion of blood or blood products may be indicated. A consistent message emerging from the review is that the principles of transfusion medicine do not differ between HIV-negative and -positive patients. The aim of the review is to provide clinicians with a practical and succinct overview of the haematological abnormalities and clinical circumstances most commonly encountered in the HIV setting, while focusing on the rational and appropriate use of blood and blood products for HIV patients. Important ethical considerations in dealing with both the collection and transfusion blood and blood products in the HIV era have also been addressed. S Afr J HIV Med 2012;13(2):87-103.

The Role of Carnitine Supplementation during Valproic Acid Therapy

2000 ◽  
Vol 34 (5) ◽  
pp. 630-638 ◽  
Author(s):  
Jackie Y Raskind ◽  
Gladys M El-Chaar
Keyword(s):  
Valproic Acid ◽  
Advisory Committee ◽  
Randomized Clinical Trials ◽  
Pediatric Population ◽  
Carnitine Deficiency ◽  
Carnitine Supplementation ◽  
Acid Therapy ◽  
Pediatric Neurology ◽  
Valproic Acid Therapy

OBJECTIVE: To review the pathophysiology and significance of valproic acid–induced carnitine deficiency; to present and evaluate the literature pertaining to carnitine supplementation in pediatric patients receiving valproic acid; and to present the consensus guidelines for carnitine supplementation during valproic acid therapy. DATA SOURCES: A MEDLINE search (1966–December 1998) restricted to English-language literature, using MeSH headings of carnitine and valproic acid, was conducted to identify clinically relevant articles. Selected articles and references focusing on the pediatric population were included for review. DATA EXTRACTION: Study design, patient population, methods, and clinical outcomes were evaluated. DATA SYNTHESIS: Valproic acid, a widely used antiepileptic agent in the pediatric population, is limited by a 1/800 incidence of fatal hepatotoxicity in children under the age of two years. Carnitine is an essential amino acid necessary in β-oxidation of fatty acids and energy production in cellular mitochondria. It has been hypothesized that valproic acid may induce a carnitine deficiency in children and cause nonspecific symptoms of deficiency, hepatotoxicity, and hyperammonemia. Relevant published case reports and trials studying this relationship are evaluated, and a consensus statement by the Pediatric Neurology Advisory Committee is reviewed. CONCLUSIONS: Despite the lack of prospective, randomized clinical trials documenting efficacy of carnitine supplementation in preventing valproic acid–induced hepatotoxicity, the few limited studies available have shown carnitine supplementation to result in subjective and objective improvements along with increases in carnitine serum concentrations in patients receiving valproic acid. The Pediatric Neurology Advisory Committee in 1996 provided more concrete indications on the role of carnitine in valproic acid therapy, such as valproic acid overdose and valproic acid–induced hepatotoxicity. Carnitine was strongly recommended for children at risk of developing a carnitine deficiency. Although carnitine has been well tolerated, future studies are needed to evaluate the efficacy of prophylactic carnitine supplementation for the prevention of hepatotoxicity.

Decision-Making

2017 ◽  
pp. 44-67
Author(s):  
Julie Neal
Keyword(s):  
Decision Making ◽  
Advisory Committee ◽  
Educational Programs ◽  
Workforce Education ◽  
Regional Economies ◽  
Education Programs ◽  
Advisory Committees ◽  
Informed Decisions ◽  
Decision Making Processes

The demand for accountability and measurement regarding educational programs in community colleges makes the decision-making process of advisory committees more important than ever. The role of the advisory committee for educational workforce programs is changing, and becoming increasingly necessary, due to legislative actions and consistent changes in the workforce. Business, industry, and higher-education institutions are adapting programs to fit thriving regional economies, and calling upon advisory committees to make major decisions within their organizations. Perceptions of and experiences with the decision-making processes that educational practitioners and workforce advisory-committee members utilize to make informed decisions for workforce-education programs are vital to their success. This chapter reveals the best practices that business and industry use to make informed decisions, including how to utilize those practices to include educational entities.

The Roles and Characteristics of Advisory Committees

2017 ◽  
pp. 28-43
Author(s):  
Julie Neal
Keyword(s):  
Decision Making ◽  
Advisory Committee ◽  
Workforce Education ◽  
Effective Practices ◽  
Leadership Roles ◽  
Common Goal ◽  
Advisory Committees ◽  
Balance Decision ◽  
The Voice

The advisory committee represents the institution, as the voice of the department, utilizing effective practices and strategies in decision-making. Because workforce education is technical and complex in nature, experienced and knowledgeable industry-based individuals are needed to advise, guide, and make decisions to achieve optimum outcomes. Key individuals have the ability to influence a group to achieve a common goal. The members have established respect and trust among the stakeholders, and are better prepared to handle the leadership roles and achieve results for the committee. The committee focuses on equal representation and balance; decision-making process; and acting as the voice of the project. This chapter focuses on the role of advisory committees. The chapter will also concentrate on the characteristics that comprise an advisory committee, and address identifying the most effective members to include on a committee.

scholarly journals The role of the China Experts Advisory Committee on Immunization Program

Vaccine ◽  
2010 ◽  
Vol 28 ◽  
pp. A84-A87 ◽  
Author(s):  
Jingshan Zheng ◽  
Yuqing Zhou ◽  
Huaqing Wang ◽  
Xiaofeng Liang
Keyword(s):  
Advisory Committee ◽  
Immunization Program

scholarly journals Australia's pharmaceutical benefits system: flawed but improving, and better than anywhere else

2001 ◽  
Vol 24 (2) ◽  
pp. 7 ◽  
Author(s):  
Andrew Dalton
Keyword(s):  
Advisory Committee ◽  
Current Process ◽  
The Future ◽  
The Media ◽  
The Subject ◽  
Better Than ◽  
Pharmaceutical Benefits Scheme

The composition and role of the Pharmaceutical Benefits Advisory Committee (PBAC) has been the subject ofacrimonious debate through the media in recent months, with accusations of government subjugation to strongindustry lobby groups at the future expense of the Australian taxpayer. An understanding of the issues at thismore political level is helped by appreciation of the rationale for the current process of listing drugs forreimbursement on the Pharmaceutical Benefits Scheme (PBS). I will try to give the non-economist reader anoverview of the system and share some perceptions of the strengths and weaknesses of what is fundamentally agood system.

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