Novel Approaches to Photon Detection and Timing for 7-Wavelength Time Domain Optical Mammography

Author(s):  
E. Ferocino ◽  
E. Martinenghi ◽  
A. Dalla Mora ◽  
A. Pifferi ◽  
R. Cubeddu ◽  
...  
Instruments ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 18
Author(s):  
Fabio Acerbi ◽  
Anurag Behera ◽  
Alberto Dalla Mora ◽  
Laura Di Sieno ◽  
Alberto Gola

Silicon photomultipliers (SiPM) are pixelated single-photon detectors combining high sensitivity, good time resolution and high dynamic range. They are emerging in many fields, such as time-domain diffuse optics (TD-DO). This is a promising technique in neurology, oncology, and quality assessment of food, wood, and pharmaceuticals. SiPMs can have very large areas and can significantly increase the sensitivity of TD-DO in tissue investigation. However, such improvement is currently limited by the high detector noise and the worsening of SiPM single-photon time resolution due to the large parasitic capacitances. To overcome such limitation, in this paper, we present two single-photon detection modules, based on 6 × 6 mm2 and 10 × 10 mm2 SiPMs, housed in vacuum-sealed TO packages, cooled to −15 °C and −36 °C, respectively. They integrate front-end amplifiers and temperature controllers, being very useful instruments for TD-DO and other biological and physical applications. The signal extraction from the SiPM was improved. The noise is reduced by more than two orders of magnitude compared to the room temperature level. The full suitability of the proposed detectors for TD-DO measurements is outside the scope of this work, but preliminary tests were performed analyzing the shape and the stability of the Instrument Response Function. The proposed modules are thus fundamental building blocks to push the TD-DO towards deeper investigations inside the body.


2005 ◽  
Vol 50 (11) ◽  
pp. 2429-2449 ◽  
Author(s):  
Dirk Grosenick ◽  
K Thomas Moesta ◽  
Michael Möller ◽  
Jörg Mucke ◽  
Heidrun Wabnitz ◽  
...  

2021 ◽  
Author(s):  
Giulia Maffeis ◽  
Edoardo Ferocino ◽  
Alberto Dalla Mora ◽  
Rinaldo Cubeddu ◽  
Antonio Pifferi ◽  
...  

Author(s):  
H. Rinneberg ◽  
D. Grosenick ◽  
H. Wabnitz ◽  
H. Danlewski ◽  
K. Moesta ◽  
...  

2010 ◽  
Vol 8 (2) ◽  
pp. 206-209
Author(s):  
马艺闻 Yiwen Ma ◽  
高峰 Feng Gao ◽  
阮平巧 Pingqiao Ruan ◽  
杨芳 Fang Yang ◽  
赵会娟 Huijuan Zhao

2005 ◽  
Vol 12 (10) ◽  
pp. 1355
Author(s):  
Xavier Intes ◽  
Salim Djeziri ◽  
Zahia Ichalalene ◽  
Niculae Mincu ◽  
Yong Wang ◽  
...  

2005 ◽  
Vol 12 (8) ◽  
pp. 934-947 ◽  
Author(s):  
Xavier Intes

2009 ◽  
Author(s):  
Yiwen Ma ◽  
Jingyi Wang ◽  
Feng Gao ◽  
Fang Yang ◽  
Huijuan Zhao ◽  
...  

2005 ◽  
Vol 4 (5) ◽  
pp. 483-496 ◽  
Author(s):  
Herbert Rinneberg ◽  
Dirk Grosenick ◽  
K. Thomas Moesta ◽  
Jörg Mucke ◽  
Bernd Gebauer ◽  
...  

Optical mammography is one of several new techniques for breast cancer detection and characterization presently under development for clinical use that provide information other than morphologic, in particular on the biochemical and metabolic state of normal and diseased tissue. In breast tissue, scattering of red to near infrared (NIR) light dominates absorption and NIR light may penetrate several centimeters through the breast. Optical mammography avoids the use of ionizing radiation and offers the power of diffuse optical spectroscopy. However, because of strong light scattering, spatial resolution of optical mammography is generally low. The paper reviews the results of a clinical study on scanning time-domain optical mammography comprising 154 patients carrying a total of 102 carcinomas validated by histology. Ninety two of these tumors were detected in optical mammograms retrospectively and for 87 of the detected tumors optical properties and tissue parameters were derived. In addition developments on instrumentation and data analysis are covered and possible improvements of optical mammography are briefly discussed.


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