Advances in Single-Photon Detection and Timing for Time Domain Multi-Wavelength Optical Mammography

Author(s):  
Edoardo Ferocino ◽  
Edoardo Martinenghi ◽  
Alberto Dalla Mora ◽  
Antonio Pifferi ◽  
Rinaldo Cubeddu ◽  
...  
Instruments ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 18
Author(s):  
Fabio Acerbi ◽  
Anurag Behera ◽  
Alberto Dalla Mora ◽  
Laura Di Sieno ◽  
Alberto Gola

Silicon photomultipliers (SiPM) are pixelated single-photon detectors combining high sensitivity, good time resolution and high dynamic range. They are emerging in many fields, such as time-domain diffuse optics (TD-DO). This is a promising technique in neurology, oncology, and quality assessment of food, wood, and pharmaceuticals. SiPMs can have very large areas and can significantly increase the sensitivity of TD-DO in tissue investigation. However, such improvement is currently limited by the high detector noise and the worsening of SiPM single-photon time resolution due to the large parasitic capacitances. To overcome such limitation, in this paper, we present two single-photon detection modules, based on 6 × 6 mm2 and 10 × 10 mm2 SiPMs, housed in vacuum-sealed TO packages, cooled to −15 °C and −36 °C, respectively. They integrate front-end amplifiers and temperature controllers, being very useful instruments for TD-DO and other biological and physical applications. The signal extraction from the SiPM was improved. The noise is reduced by more than two orders of magnitude compared to the room temperature level. The full suitability of the proposed detectors for TD-DO measurements is outside the scope of this work, but preliminary tests were performed analyzing the shape and the stability of the Instrument Response Function. The proposed modules are thus fundamental building blocks to push the TD-DO towards deeper investigations inside the body.


2020 ◽  
Vol 10 (3) ◽  
pp. 1101 ◽  
Author(s):  
Alberto Dalla Mora ◽  
Laura Di Sieno ◽  
Rebecca Re ◽  
Antonio Pifferi ◽  
Davide Contini

This work reviews physical concepts, technologies and applications of time-domain diffuse optics based on time-gated single-photon detection. This particular photon detection strategy is of the utmost importance in the diffuse optics field as it unleashes the full power of the time-domain approach by maximizing performances in terms of contrast produced by a localized perturbation inside the scattering medium, signal-to-noise ratio, measurement time and dynamic range, penetration depth and spatial resolution. The review covers 15 years of theoretical studies, technological progresses, proof of concepts and design of laboratory systems based on time-gated single-photon detection with also few hints on other fields where the time-gated detection strategy produced and will produce further impact.


2021 ◽  
Vol 50 (1) ◽  
pp. 20211016-20211016
Author(s):  
吴静远 Jingyuan Wu ◽  
刘肇国 Zhaoguo Liu ◽  
张彤 Tong Zhang

Science ◽  
2021 ◽  
Vol 372 (6540) ◽  
pp. 356.3-356
Author(s):  
Ian S. Osborne

Materials ◽  
2018 ◽  
Vol 11 (6) ◽  
pp. 869 ◽  
Author(s):  
Andreas Hans ◽  
Philipp Schmidt ◽  
Christian Ozga ◽  
Gregor Hartmann ◽  
Xaver Holzapfel ◽  
...  

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