A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease

Abstract Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Self Introduction Malignant ventricular arrhythmia contributes to approximately half of the sudden cardiac deaths. In common practice, echocardiography is used to identify structural heart diseases that are the most frequent substrate of VA. Identification and prognostication of structural heart diseases are very important as they are the main determinant of poor prognosis of ventricular arrhythmia. Purpose : The objective of this study is to determine whether cardiac magnetic resonance (CMR) may identify structural heart disease (SHD) in patients with ventricular arrhythmia who had no pathology observed on echocardiography. Methods : A total of 864 consecutive patients were enrolled in this single-center prospective study with significant ventricular arrhythmia. VA was characterized as >1000 ventricular ectopic beats per 24 hours, non-sustained ventricular arrhythmia, sustained ventricular arrhythmia, and no pathological lesion on echocardiography. The primary endpoint was the detection of SHD with CMR. Secondary endpoints were a composite of CMR detection of SHD and abnormal findings not specific for a definite SHD diagnosis. Results : CMR studies were used to diagnose SHD in 212 patients (24.5%) and abnormal findings not specific for a definite SHD diagnosis in 153 patients (17.7%). Myocarditis (n = 84) was the more frequent disease, followed by arrhythmogenic cardiomyopathy (n = 51), ischemic heart disease (n = 32), dilated cardiomyopathy (n = 17), hypertrophic cardiomyopathy (n = 12), congenital cardiac disease (n = 08), left ventricle noncompaction (n = 5), and pericarditis (n = 3). The strongest univariate and multivariate predictors of SHD on CMR images were chest pain (odds ratios [OR]: 2.5 and 2.33, respectively) and sustained ventricular tachycardia (ORs: 2.62 and 2.21, respectively). Conclusion : Our study concludes that SHD was able to be identified on CMR imaging in a significant number of patients with malignant VA and completely normal echocardiography. Chest pain and sustained ventricular tachycardia were the two strongest predictors of positive CMR imaging results. Abstract Figure. Distribution of different SHD

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Long-Term Results of Radiofrequency Catheter Ablation in Non-ischemic Sustained Ventricular Tachycardia with Underlying Heart Disease. Nonuniform Arrhythmogenic Substrate and Mode of Ablation.

Japanese Heart Journal ◽

10.1536/ihj.37.183 ◽

1996 ◽

Vol 37 (2) ◽

pp. 183-194 ◽

Cited By ~ 2

Author(s):

Masaomi CHINUSHI ◽

Yoshifusa AIZAWA ◽

Kouji OHHIRA ◽

Akira ABE ◽

Akira SHIBATA

Keyword(s):

Heart Disease ◽

Ventricular Tachycardia ◽

Catheter Ablation ◽

Radiofrequency Catheter Ablation ◽

Sustained Ventricular Tachycardia ◽

Long Term Results ◽

Arrhythmogenic Substrate

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Clinical comparative study on efficacy and safety for treatment of coronary heart disease with cobalt-base alloy bio absorbable polymer sirolimus-eluting stent and PARTNER stent

Heart ◽

10.1136/heartjnl-2011-300867.435 ◽

2011 ◽

Vol 97 (Suppl 3) ◽

pp. A149-A149 ◽

Cited By ~ 1

Author(s):

Z. Li ◽

H. Wang ◽

S. Lv ◽

L. Liu ◽

W. Guo ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Comparative Study ◽

Base Alloy ◽

Efficacy And Safety ◽

Cobalt Base Alloy ◽

Sirolimus Eluting Stent ◽

Cobalt Base

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Efficacy and Safety of Zhenyuan Capsule for Coronary Heart Disease with Abnormal Glucose and Lipid Metabolism: Study Protocol for a Randomized, Double-Blind, Parallel-Controlled, Multicenter Clinical Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2018/1716430 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Yu Qiao ◽

Jingchun Zhang ◽

Yue Liu ◽

Zhiqi Liang ◽

Yuhua Wang ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Lipid Metabolism ◽

Blood Glucose ◽

Glycosylated Hemoglobin ◽

Postprandial Blood Glucose ◽

Common Disease ◽

Efficacy And Safety ◽

Double Blind ◽

Glucose And Lipid Metabolism

Background. Coronary heart disease (CHD) and abnormal glucose and lipid metabolism are closely associated and generally coexist. The Qi and Yin deficiency syndrome is a common disease pattern encountered in traditional Chinese medicine. We designed a protocol to determine the effectiveness and safety of Zhenyuan capsules for CHD with abnormal glucose and lipid metabolism. Methods. This multicenter, randomized, double-blind, parallel-controlled trial was designed in accordance with the CONSORT. We will recruit 200 eligible male patients aged 45–75 years from three participating centers and randomly assign them to treatment and control groups (1 : 1). The primary indicators are glycosylated hemoglobin, fasting blood glucose, 2-hour postprandial blood glucose, and triglyceride levels. The secondary indicators are the Seattle Angina Questionnaire, TCM symptom indicators, ultrasonic cardiography finding, coagulation indicator, and P-selectin level. Measurements will be performed at baseline (T0), the end of the run-in period (T1), and weeks 4 (T2), 8 (T3), and 12 (T4) of the treatment period. Adverse events will be monitored during the trial. Discussion. This study aims to evaluate the efficacy and safety of Zhenyuan capsules in patients with CHD and abnormal glucose and lipid metabolism. The results will provide critical evidence of the usefulness of the Chinese herbal medicine for CHD with abnormal glucose and lipid metabolism. Trial Registration. This trial is registered with the Chinese Clinical Trials Registry, with identifier number ChiCTR-TRC-14004639, May 4, 2014.

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