scholarly journals Characterization of the non-linear rate-dependency of QT interval in humans

EP Europace ◽  
2003 ◽  
Vol 5 (2) ◽  
pp. 163-170 ◽  
Author(s):  
G Malfatto
Keyword(s):  
Qt Interval ◽  
Rate Dependency ◽  
Linear Rate ◽  
Non Linear

Non-linear imaging and characterization of atherosclerotic arterial tissue using combined SHG and FLIM microscopy

2015 ◽  
Vol 8 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Riccardo Cicchi ◽  
Enrico Baria ◽  
Christian Matthäus ◽  
Marta Lange ◽  
Annika Lattermann ◽  
...  
Keyword(s):  
Arterial Tissue ◽  
Non Linear

Towards non-linear inversion for characterization of time-lapse phenomena through numerical modelling

2003 ◽  
Vol 51 (4) ◽  
pp. 285-293 ◽  
Author(s):  
A. Abubakar ◽  
P.M. van den Berg ◽  
J.T. Fokkema
Keyword(s):  
Numerical Modelling ◽  
Time Lapse ◽  
Linear Inversion ◽  
Non Linear

Abstract 050: Fine-mapping and Bioinformatics Characterization of QT Interval Loci in African Americans: The Population Architecture Using Genomics and Epidemiology (PAGE) Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Christy L Avery ◽  
Praveen Sethupathy ◽  
Steven Buyske ◽  
Q. C He ◽  
Dan Y Lin ◽  
...  
Keyword(s):  
African American ◽  
African Americans ◽  
Fine Mapping ◽  
Qt Interval ◽  
Functional Characterization ◽  
Regulatory Elements ◽  
European Ancestry ◽  
Functional Evaluation ◽  
Human Cardiomyocytes

The QT interval (QT) is a heritable trait and its prolongation is an established risk factor for ventricular tachyarrhythmia and sudden cardiac death. Most genetic studies of QT have examined populations of European ancestry, although the increased genetic diversity in populations of African descent provides opportunity for fine-mapping, which can help narrow association signals and identify candidates for functional characterization. We examined whether eleven previously identified QT loci comprising 6,681 variants on the Illumina Metabochip array were associated with QT in 7,516 African American participants from the Atherosclerosis Risk in Communities study and Women’s Health Initiative clinical trial. Among associated loci, we used conditional analyses and queried bioinformatics databases to identify and functionally categorize signals. We identified nine of the eleven QT loci in African American populations ( P <0.0045 under an additive genetic model adjusting for ancestry and demographic characteristics: NOS1AP, ATP1B1, SCN5A, SLC35F1, KCNH2, KCNQ1, LITAF, NDRG4, and RFFL ). We also identified two independent secondary signals in NOS1AP and ATP1B1 ( P < 7.4x10 −6 ). Conditional analyses adjusting for published loci in European populations demonstrated that eight of these eleven SNPs (nine primary; two secondary) were independent of previously reported SNPs. We then performed the first bioinformatics-based functional characterization of QT loci using the eleven primary and secondary variants and SNPs in strong LD (r 2 > 0.5) among these African American participants. Only the SCN5A locus included a non-synonymous coding variant (rs1805124, H558R, r 2 = 0.7 with primary SNP rs9871385, P = 4.7x10 −4 ). The remaining ten loci harbored variants located exclusively within non-coding regions. Specifically, three contained SNPs within candidate long-range regulatory elements in human cardiomyocytes, five were in or near annotated promoter regions, and the remaining two were in un-annotated, but highly conserved non-coding elements. Several of the QT risk alleles at these SNPs significantly alter the predicted binding affinity for transcription factors, such as TBX5 and AhR, which have been previously implicated in cardiac formation and function. In summary, the findings provide compelling evidence that the same genes influence variation in QT across global populations and that additional, independent signals exist in African Americans. Moreover, of those SNPs identified as strong candidates for functional evaluation, the majority implicate gene regulatory dysfunction in QT prolongation.

Adsorption of Iron (II) Ion by Using Magnetite-Bentonite-Based Monolith from Water

2021 ◽  
Vol 892 ◽  
pp. 10-16
Author(s):  
Ismi Nurul ◽  
Syamsuddin Yanna ◽  
Adisalamun ◽  
Aulia Sugianto Veneza ◽  
Darmadi
Keyword(s):  
Magnetic Properties ◽  
Magnetic Particles ◽  
Solution Concentration ◽  
Iron Solution ◽  
Monolayer Adsorption ◽  
Coprecipitation Process ◽  
Non Linear ◽  
Magnetic Loading ◽  
Langmuir Constants

In this study, iron removal was carried out by the adsorption process as a well-known method of removing heavy metal. Natural bentonite with magnetic properties in a monolithic form or Magnetite-Bentonite-based Monolith (MBM) adsorbent was used as an adsorbent to remove Iron (II) ion from the aqueous solution. The magnetic properties of adsorbents are obtained by adding magnetite (Fe3O4), which is synthesized by the coprecipitation process. The characterization of magnetic properties was performed using the Vibrating Sample Magnetometer (VSM). VSM results showed that the magnetic particles were ferromagnetic. Adsorption efficiency, isotherm model, and adsorption kinetics were investigated in a batch system with iron solution concentration varied from 2 to 10 mg/L and magnetite loading at 2% and 5% w/w. The highest removal efficiency obtained reached 89% with a 5% magnetite loading. The best fit to the data was obtained with the Langmuir isotherm (non-linear) with maximum monolayer adsorption capacity (Qo) at 5% magnetic loading MBM adsorbent is 0.203 mg/g with Langmuir constants KL and aL are 2.055 L/g and 10.122 L/mg respectively. The pseudo-first-order (non-linear) kinetic model provides the best correlation of the experimental data with the rate of adsorption (k1) with magnetite loading 2% and 5%, respectively are 0.024 min-1 and 0.022 min-1.

Synthesis, structure and characterization of a hybrid centrosymmetric material (4-dimethylaminopyridinium nitrate gallic acid monohydrate) well-designed for non-linear optics

2018 ◽  
Vol 1151 ◽  
pp. 126-134 ◽  
Author(s):  
Nasreddine Ennaceur ◽  
Boutheina Jalel ◽  
Rokaya Henchiri ◽  
Marie Cordier ◽  
Isabelle Ledoux-Rak
Keyword(s):  
Gallic Acid ◽  
Linear Optics ◽  
Non Linear Optics ◽  
Non Linear

In situ 3D characterization of membrane fouling by yeast suspensions using two-photon femtosecond near infrared non-linear optical imaging

2006 ◽  
Vol 280 (1-2) ◽  
pp. 124-133 ◽  
Author(s):  
David Hughes ◽  
Uday K. Tirlapur ◽  
Robert Field ◽  
Zhanfeng Cui
Keyword(s):  
Optical Imaging ◽  
Membrane Fouling ◽  
Near Infrared ◽  
Two Photon ◽  
Non Linear ◽  
Linear Optical

Characterization of abdominally acquired uterine electrical signals in humans, using a non-linear analytic method

2006 ◽  
Vol 44 (1-2) ◽  
pp. 117-123 ◽  
Author(s):  
William L. Maner ◽  
Lynette B. MacKay ◽  
George R. Saade ◽  
Robert E. Garfield
Keyword(s):  
Analytic Method ◽  
Electrical Signals ◽  
Non Linear
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