Regenerative medicine in the field of pain medicine: Prolotherapy, platelet-rich plasma therapy, and stem cell therapy—Theory and evidence

2011 ◽  
Vol 15 (2) ◽  
pp. 74-80 ◽  
Author(s):  
David M. DeChellis ◽  
Megan Helen Cortazzo
2019 ◽  
Vol 14 (3) ◽  
pp. 226-229 ◽  
Author(s):  
Wei Zhou ◽  
Ming Qu ◽  
Yajie Lv ◽  
Jinyu Zhu

Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease with multiple etiologies that more frequently occurs in middle-aged and young people. ONFH is the main cause of hip replacement in young patients. Since Professor Hernigou first reported the use of stem cells in the treatment of early stage ONFH, a large number of studies have demonstrated the potential of stem cells in the treatment of adult patients with ONFH. With the rise of interdisciplinary stem cell therapy combined with platelet-rich plasma therapy, gene therapy or other methods have gradually attracted the attention of researchers. This article summarizes the current advances in stem cell therapy for ONFH, as well as the problems and challenges, which may provide reference for further research.


2009 ◽  
Vol 84 (10) ◽  
pp. 859-861 ◽  
Author(s):  
Timothy O'Brien ◽  
Frank P. Barry

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Michelle R. Santoso ◽  
Phillip C. Yang

Stem cell therapy has broad applications in regenerative medicine and increasingly within cardiovascular disease. Stem cells have emerged as a leading therapeutic option for many diseases and have broad applications in regenerative medicine. Injuries to the heart are often permanent due to the limited proliferation and self-healing capability of cardiomyocytes; as such, stem cell therapy has become increasingly important in the treatment of cardiovascular diseases. Despite extensive efforts to optimize cardiac stem cell therapy, challenges remain in the delivery and monitoring of cells injected into the myocardium. Other fields have successively used nanoscience and nanotechnology for a multitude of biomedical applications, including drug delivery, targeted imaging, hyperthermia, and tissue repair. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been widely employed for molecular and cellular imaging. In this mini-review, we focus on the application of superparamagnetic iron oxide nanoparticles in targeting and monitoring of stem cells for the treatment of myocardial infarctions.


2012 ◽  
Vol 73 (12) ◽  
pp. 1287-1294 ◽  
Author(s):  
Dominique Charron ◽  
Caroline Suberbielle-Boissel ◽  
Ryad Tamouza ◽  
Reem Al-Daccak

Author(s):  
Nagendra Kumar Chandrawanshi ◽  
Shekhar Verma

Cancer is the most prevalent and dangerous disease, and it leads to millions of deaths worldwide. Generally, metastatic cancer cells are not eradication by conventional surgical operative or chemotherapy-based treatment. New pathways have been established in various arenas such as unique biology, modulators regulatory mechanism, directional migration, self-renewal, etc. The individual pathways can be employed as therapeutic carriers, specific drug targeting, generation of acquiring nature immune cells, and regenerative medicine. The present scenario, stem cell therapy, focused on a promising tool for targeted cancer treatment. Stem cells also utilized as viruses and nanoparticles carry to enhance the primary therapeutic application in various dimensions such as cancer target therapy, regenerative medicine, immune-modulating therapy, and anticancer drugs screening. Furthermore, the rapid development in next-generation sequencing techniques and cancer genomics and proteomics analysis approaches are making therapeutics targeting organ-specific cancer more precise and efficient.


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