Clinical Impact of the TCF7L2 Gene rs7903146 Type 2 Diabetes Mellitus Risk Polymorphism in Women with Gestational Diabetes Mellitus: Impaired Glycemic Control and Increased Need of Insulin Therapy

2019 ◽  
Vol 128 (10) ◽  
pp. 663-666
Author(s):  
Laura Potasso ◽  
Nikolaos Perakakis ◽  
Apostolia Lamprinou ◽  
Elektra Polyzou ◽  
Dimitrios Kassanos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Therapy ◽  
Glucose Tolerance Test ◽  
Risk Allele ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Tcf7l2 Rs7903146

Abstract Background The single nucleotide polymorphism in TCF7L2 rs7903146 is associated with an increased risk of type 2 diabetes mellitus and gestational diabetes mellitus. Mechanisms by which this mutation acts, and its impact on the clinical course of the diseases remain unclear. Here we investigated the clinical impact of the T risk allele in women with gestational diabetes mellitus. Methods We genotyped the C/T polymorphism in 164 Caucasian women with GDM (German n=114; Greek n=50). The impact of the T allele on the results of the 75g oral-glucose-tolerance-test, and on the required therapy (diet/lifestyle or insulin) was investigated. Results During oral-glucose-tolerance-test, women harboring the T allele displayed significantly higher glucose values at 60 min (p=0.034) and were more likely to require insulin therapy even after adjusting for confounders, such as BMI and age. Conclusion These results provide evidence that the T risk allele in TCF7L2 rs7903146 is associated with failure in early postprandial glycemic control and requirement of insulin therapy in women with gestational diabetes mellitus, even after adjusting for confounding factors such BMI and age.

scholarly journals Alarin Level Response to an Oral Glucose Tolerance Test in Subjects with Gestational Diabetes Mellitus

2020 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

Alarin has been reported to ameliorate insulin resistance in type 2 diabetis mellitus. However, until now, there is no report examined the relationship between alarin and gestational diabetes mellitus (GDM). Therefore, the purpose of this study is to examine the level of alarin in subjects with and without gestational diabetes mellitus. 30 healthy and 30 gestational diabetes mellitus subjects were recruited for this study. A 2-hour 75 g oral glucose tolerance test (OGTT) was performed at 24–28 weeks of pregnancy. GDM were diagnosed using nationally endorsed criteria (fasting [FPG], 1- or 2-hour blood glucose [at least one abnormal value]. Plasma alarin level was measured by ELISA. Plasma alarin levels were significantly higher GDM subjects than in healthy individuals (12. 3±1.4 ng/mL vs 7.8±0.8 ng/mL; p < .05).1- (18. 8±1.9 ng/mL) and 2-hour (24. 2±3.1 ng/mL) alarin levels in women with GDM were significantly increased at OGTT compared with women without GDM [1- (9.4±0.9 ng/mL); 2- (9.7±0.6 ng/mL)]. Plasma alarin positively correlated with FBG, HbA1c, HOMA-IR and insulin). The above results suggest that alarin might be associated in the pathogenesis of gestational diabetes mellitus.

scholarly journals GESTATIONAL DIABETES MELLITUS

2012 ◽  
Vol 19 (04) ◽  
pp. 462-468
Author(s):  
M. IKRAM ◽  
SYED HAIDER HASAN ALAM ◽  
SHAFQAT MUKHTAR ◽  
M. Saeed
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Glucose Tolerance Test ◽  
Fasting Blood Glucose ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

Introduction: Gestational diabetes mellitus is common disorder in pregnancy. It is associated with adverse pregnancy outcome. There is no consensus regarding the optimal approach to screening of gestational diabetes mellitus. The present study has tried toobserve the value of fasting blood glucose in screening of gestational diabetes. Objective: To determine the frequency of patients in whomfasting blood glucose and 100gm glucose tolerance show agreement for screening of gestational diabetes mellitus at 24 -28 wks. Studydesign: Comparative cross sectional study. Settings: The study was conducted at Gynecology and Obstetrics department Shaikh ZayedFederal Post Graduate Institute Lahore. Duration of study with dates: 6 months from 12Nov 2010 to 11 May 2011. Material and method: Thestudy included 135 booked patients with positive family history of diabetes mellitus. All patients underwent fasting blood glucose at 24-28 weeksof gestation, regardless of results of fasting blood glucose on next visit they underwent 100g oral glucose tolerance test (OGTT). The agreementbetween fasting blood glucose and 100g oral glucose tolerance test was calculated in frequency and percentages. Results: The mean age ofwomen in studied population was 27.15±3.70.Out of 135 patients 86.7 %( 117) showed agreement between results of fasting blood glucose and100g OGTT while 13.31 %( 18) showed no agreement between both of the tests. Conclusions: Fasting blood glucose is a good screeningoption for gestational diabetes mellitus along with positive history. It provides a simple, cheap and more practical test for screening of gestationaldiabetes mellitus. However diagnostic confirmation with 100g OGTT should be done.

scholarly journals Factors in Gestational Diabetes Mellitus Predicting the Needs for Insulin Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Ya Zhang ◽  
Jiashen Shao ◽  
Feifei Li ◽  
Xianming Xu
Keyword(s):  
Diabetes Mellitus ◽  
Multivariate Analysis ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Therapy ◽  
Nutrition Therapy ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Operating Characteristics ◽  
Significant Difference

Objective.To identify factors predicting the need for insulin therapy in pregnancies complicated by gestational diabetes mellitus (GDM).Methods. A total of 1352 patients with GDM diagnosed by the 75-g/2-h oral glucose tolerance test (OGTT) were enrolled in this study. Univariate and multivariate analysis were performed; receiver operating characteristics (ROC) were also drawn.Results. There was a significant difference in factors such as maternal age, pregestational BMI, first visit SBP, first visit DBP, FBG of first visit, FBG at time of OGTT, 75-g OGTT glucose value (fasting, after 1 h and 2 h), and serum HbA1c level at diagnosis between patients with insulin therapy and patients with medical nutrition therapy (MNT) alone. Multivariate analysis showed that higher FBG at time of OGTT, first 75 g OGTT 2 h plasma glucose, and HbA1c concentration at diagnosis lead to more likely need of insulin therapy.Conclusion. The probability of insulin therapy can be estimated in pregnant women with GDM based on fasting and 2 h glucose values during OGTT and HbA1c value at diagnosis of GDM.

Sign in / Sign up

Export Citation Format

Share Document