Pd-catalyzed Arylation of 1,2-Amino Alcohol Derivatives via beta-Carbon Elimination

Synlett ◽

10.1055/a-1699-4766 ◽

2021 ◽

Author(s):

Ruben Martin ◽

Miguel Pericàs ◽

Miriam Sau

Keyword(s):

Amino Alcohol ◽

Amino Alcohols ◽

Aryl Halides ◽

Entry Point ◽

New Entry

Herein, we describe a Pd-catalyzed arylation of 1,2-amino alcohols with aryl halides enabled by a retroallylation manifold. This protocol constitutes a new entry point to beta-arylated aldehydes via the intermediacy of in situ generated enamine intermediates. The protocol is characterized by its exquisite regioselectivity profile and broad substrate scope – including challenging substrate combinations –, even in an enantioselective manner

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Syntheses of 1,2-Amino Alcohols and Their Applications for Oxazaborolidine Catalyzed Enantioselective Reduction of Aromatic Ketones

Australian Journal of Chemistry ◽

10.1071/ch06412 ◽

2007 ◽

Vol 60 (3) ◽

pp. 196 ◽

Cited By ~ 4

Author(s):

Namdev S. Vatmurge ◽

Braja G. Hazra ◽

Vandana S. Pore

Keyword(s):

Amino Alcohol ◽

Good Yield ◽

Asymmetric Reduction ◽

Enantiomeric Excess ◽

Amino Alcohols ◽

Secondary Alcohols ◽

Aromatic Ketones ◽

Enantioselective Reduction ◽

Aryl Ketones

Six new chiral 1,2-amino alcohol derivatives have been synthesized starting from (1R,2R)-2-amino-1-phenylpropane-1,3-diol. Asymmetric reduction of aryl ketones with in-situ generated oxazaborolidine from these amino alcohol derivatives and BH3·Me2S afforded secondary alcohols with good yield and moderate to high enantiomeric excess.

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ChemInform Abstract: Synthesis of 1,2- and 1,4-Amino Alcohols from 1,3-Dienes via Oxazines. Rearrangements of 1,4-Amino Alcohol Derivatives to Oxazolines.

ChemInform ◽

10.1002/chin.201037029 ◽

2010 ◽

Vol 41 (37) ◽

pp. no-no

Author(s):

Lukas Werner ◽

Jason Reed Hudlicky ◽

Martina Wernerova ◽

Tomas Hudlicky

Keyword(s):

Amino Alcohol ◽

Amino Alcohols

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ChemInform Abstract: Stereocontrolled “One-Pot” Organometallic Addition-Ring Opening Reaction of α,β-Aziridine Aldehydes. A New Entry to syn 1,2-Amino Alcohols.

ChemInform ◽

10.1002/chin.200218044 ◽

2010 ◽

Vol 33 (18) ◽

pp. no-no

Author(s):

Giuliana Righi ◽

Simona Pietrantonio ◽

Carlo Bonini

Keyword(s):

Ring Opening ◽

Amino Alcohols ◽

One Pot ◽

Ring Opening Reaction ◽

Aziridine Aldehydes ◽

New Entry

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Research Progress on the Regulation Effect of Acupuncture on Intestinal Flora

Acupuncture & Electro-Therapeutics Research ◽

10.3727/036012921x16207330235293 ◽

2021 ◽

Vol 46 (3) ◽

pp. 191-200

Author(s):

Tian-Qi Wang ◽

Wan-Ting Lu ◽

Jia Yang

Keyword(s):

Drug Therapy ◽

Intestinal Flora ◽

Entry Point ◽

Research Progress ◽

Typical Representative ◽

The Past ◽

Acupuncture And Moxibustion ◽

Regulation Effect ◽

New Entry

More and more evidences show that the imbalance of intestinal flora is closely related to the occurrence of diseases. Through the regulation of intestinal microecology to prevent and treat diseases, it becomes a new entry point to treat diseases. As a typical representative of non-drug therapy, acupuncture and moxibustion plays an obvious role in regulating intestinal flora imbalance. This paper summarizes the effect and mechanism of acupuncture and moxibustion intervention on intestinal flora in the past ten years to provide more evidence for the treatment of diseases caused by intestinal flora imbalance.

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In situ immobilized palladium nanoparticles on surface of poly-methyldopa coated-magnetic nanoparticles (Fe3O4@PMDA/Pd): A magnetically recyclable nanocatalyst for cyanation of aryl halides with K4[Fe(CN)6]

Journal of Catalysis ◽

10.1016/j.jcat.2018.07.008 ◽

2018 ◽

Vol 365 ◽

pp. 204-212 ◽

Cited By ~ 41

Author(s):

Hojat Veisi ◽

Saba Hemmati ◽

Parisa Safarimehr

Keyword(s):

Magnetic Nanoparticles ◽

Palladium Nanoparticles ◽

Aryl Halides ◽

Magnetic Nanoparticles Fe3o4

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ChemInform Abstract: Fluorine-Containing Optically Active Allylic Alcohols: Preparation and Claisen Rearrangement as a New Entry to Highly Functionalized Fluorinated Amino Alcohol Derivatives.

ChemInform ◽

10.1002/chin.200014109 ◽

2010 ◽

Vol 31 (14) ◽

pp. no-no

Author(s):

Sheng Peng ◽

Feng-Ling Qing

Keyword(s):

Amino Alcohol ◽

Claisen Rearrangement ◽

Optically Active ◽

Allylic Alcohols ◽

New Entry

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Tricyclic psychotropic agents containing two chalcogen atoms in the central ring: 8-Substituted 6-(4-piperidyl)-6H-dibenz[b,e]-1,4-oxathiepins

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19823077 ◽

1982 ◽

Vol 47 (11) ◽

pp. 3077-3093 ◽

Cited By ~ 3

Author(s):

Karel Šindelář ◽

Jiřina Metyšová ◽

Jiří Holubek ◽

Emil Svátek ◽

Jiří Protiva ◽

...

Keyword(s):

Secondary Amine ◽

Amino Alcohol ◽

Sodium Hydride ◽

Amino Alcohols ◽

Central Ring ◽

Psychotropic Agents ◽

High Degree ◽

By Products ◽

Antiapomorphine Effect ◽

Central Depressant

2-(2-Fluorophenylthio)benzaldehydes IXa-c and 5-chloro-2-(2-fluorophenylthio)acetophenone were treated with 1-methyl-4-piperidylmagnesium chloride and 3-dimethylaminopropylmagnesium chloride, respectively, and the resulting amino alcohols VIa-c, XVII and XVIII were cyclized with sodium hydride in dimethylformamide. In addition to the title compounds Ia-c, XIX and XX, several types of by-products were obtained. Demethylation of compound Ib by the chloroformate method afforded the secondary amine IIb which was transformed to the amino alcohols IIIb and Vb. Compounds Ia-c are very potent neuroleptics with a high degree of central depressant and cataleptic activity. The amino alcohol Vb exhibits a very strong antiapomorphine effect in rats.

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