Infected nonunion and bone necrosis after intramedullary reaming of the tibia—Ilizarov bone transportation

Infected nonunion of a forearm fracture complicated by a considerable skin-muscle defect poses a great challenge to orthopaedic surgeons. The treatment strategy comprises eradication of the infection, ensuring bony union and soft tissue coverage along with functional restoration. We report a case of a 23-year-old man with an open Gustilo-Anderson IIIb fracture complicated by infected nonunion after internal fixation. After thorough surgical debridement, a considerable soft tissue defect, extensor muscle loss, and posterior interosseous nerve laceration had to be addressed. He was finally treated with bone transportation and bone lengthening followed by tendon transfers.

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Utility of technetium-99m-methylene diphosphonate single-photon emission computed tomography/computed tomography fusion in detecting post-traumatic chronic-infected nonunion in the lower limb

Nuclear Medicine Communications ◽

10.1097/mnm.0000000000001027 ◽

2019 ◽

Vol 40 (8) ◽

pp. 778-785 ◽

Cited By ~ 1

Author(s):

Qitao Song ◽

Lei Long ◽

Shuangshuang Cui ◽

Hengsheng Shu ◽

Chunyou Wan ◽

...

Keyword(s):

Computed Tomography ◽

Lower Limb ◽

Single Photon ◽

Photon Emission ◽

Emission Computed Tomography ◽

Single Photon Emission ◽

Infected Nonunion ◽

Post Traumatic ◽

Single Photon Emission Computed ◽

Photon Emission Computed Tomography

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Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures

Stem Cells International ◽

10.4061/2010/410170 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 10

Author(s):

Jean-Philippe Hauzeur ◽

Valérie Gangji

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Adult Stem Cells ◽

Bone Marrow Aspirate ◽

Direct Injection ◽

Case Series ◽

Autologous Bone Marrow ◽

Bone Necrosis ◽

Concentrated Bone Marrow ◽

Made In

Nonunion fractures and aseptic bone necrosis are two pathological conditions having some impairment of the cellular part of the repair: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direct injection—15 to 150 ml—was made in 4 case series studies. In another, the bone marrow aspirate was concentrated before injection. The results were good. In bone necrosis, only one level 1 study was published. The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse. In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%. These results are interesting but need confirmation by controlled studies.

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