1 Stereotactic radiosurgery (SRS)historical perspectives ofGamma KnifeStereotactic radiosurgery (SRS)devices forGammaKnifeLeskell, LarsGamma Knife andLeskell Gamma KnifeHistorical perspectivesGamma KnifeGamma Knifehistorical perpsectives ofGamma KnifeDevicesGamma KnifeThe Origins and Birth of the Leksell Gamma Knife

2016 ◽  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Historical Perspectives

Skull base aneurysmal bone cyst presenting with hydrocephalus: progressive residuum obliterated by Gamma Knife stereotactic radiosurgery in a pediatric patient

2020 ◽  
Vol 26 (1) ◽  
pp. 76-81
Author(s):  
George H. Tse ◽  
Feng Y. Jiang ◽  
Matthias W. R. Radatz ◽  
Saurabh Sinha ◽  
Hesham Zaki
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Pediatric Population ◽  
Bone Cyst ◽  
Disease Free Survival ◽  
Long Term Follow Up ◽  
Aneurysmal Bone Cysts ◽  
Gamma Knife Stereotactic Radiosurgery

Aneurysmal bone cysts (ABCs) are an uncommon entity predominantly encountered in the pediatric population. The skull is rarely involved, but these cysts have been reported to arise in the skull base. Traditional treatment has been with surgery alone; however, there is a gathering body of literature that reports alternative treatments that can achieve long-term disease-free survival. However, these therapies are predominantly directed at peripheral skeletal lesions. To the authors’ knowledge, this report is the first to describe long-term follow-up of the efficacy of Gamma Knife stereotactic radiosurgery for treatment of ABC residuum in the skull base that resulted in long-term patient stability and likely ABC obliteration.

Frame-Based and Mask-Based Stereotactic Radiosurgery: The Patient Experience, Compared

2021 ◽  
pp. 1-9
Author(s):  
Matthew Pavlica ◽  
Troy Dawley ◽  
Anuj Goenka ◽  
Michael Schulder
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Patient Experience ◽  
Malignant Lesion ◽  
Patient Comfort ◽  
Treatment Technique ◽  
Metastatic Lesions ◽  
Treatment Type ◽  
Lesion Type ◽  
Malignant Diagnosis

<b><i>Introduction:</i></b> Noninvasive frameless modalities have become increasingly utilized for stereotactic radiosurgery (SRS) for benign and malignant pathologies. There is minimal comparison in the literature of frame-based (FB) and mask-based (MB) SRS. With the dual capabilities of the Elekta Gamma Knife® Icon™, we sought to compare patient perceptions of FB and MB SRS with respect to comfort and pain and to examine effects of lesion type on the patient experience of SRS. <b><i>Methods:</i></b> Over a 1-year period, patients who underwent single fraction, fractionated or hypofractionated FB or MB Gamma Knife SRS at our institution were given an 8-question survey about their experience with the procedure immediately after treatment was completed. Descriptive statistics were applied. <b><i>Results:</i></b> A total of 117 patients completed the survey with 65 FB and 52 MB SRS treatments. Mean pain for FB SRS (5.64 ± 2.55) was significantly greater than mean pain for MB SRS (0.92 ± 2.24; <i>t</i><sub>114</sub> = 10.46<i>, p</i> &#x3c; 0.001). Patient comfort during the procedure was also higher for those having MB SRS (<i>p</i> &#x3c; 0.001). Mixed results were obtained when investigating if benign versus malignant diagnosis affected patient experience of SRS. For the purposes of this study, malignant diagnoses were almost entirely metastatic lesions. Diagnosis played no role on pain levels when all patients were analyzed together. The treatment technique had no effect on patient comfort in patients with benign diagnoses, while patients with malignant diagnoses treated with MB SRS were more likely to be comfortable (<i>p</i> &#x3c; 0.001). Among patient’s receiving FB treatments, diagnosis played no role on patient comfort. When only MB treatments were analyzed, patients were more likely to be comfortable if they had a malignant lesion (<i>p</i> &#x3c; 0.01). <b><i>Conclusions:</i></b> Patients treated with MB SRS experience the procedure as more comfortable and less painful compared to those treated using a FB modality. Overall, this difference was not affected by a benign versus a malignant diagnosis and the treatment type is more indicative of the patient experience during SRS. A more homogenous sample between modalities and diagnoses and further follow-up with the patient’s input on their experience would be beneficial.

scholarly journals Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience

CNS Oncology ◽  
2018 ◽  
Vol 7 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Ajay Patel ◽  
Homan Mohammadi ◽  
Tuo Dong ◽  
Kevin Ren-Yeh Shiue ◽  
Douglas Frye ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Indiana University ◽  
Gamma Knife Stereotactic Radiosurgery

Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas

Pituitary ◽  
2012 ◽  
Vol 16 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Xiaomin Liu ◽  
Hideyuki Kano ◽  
Douglas Kondziolka ◽  
Kyung-Jae Park ◽  
Aditya Iyer ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Drug Resistant ◽  
Gamma Knife Stereotactic Radiosurgery

scholarly journals Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Nathan C. Rowland ◽  
Jennifer Andrews ◽  
Daxa Patel ◽  
David V. LaBorde ◽  
Adam Nowlan ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Treatment Options ◽  
Tumor Burden ◽  
Poor Survival ◽  
Intracranial Metastasis ◽  
Temporary Reduction ◽  
Single Fraction ◽  
Curative Therapy ◽  
Gamma Knife Stereotactic Radiosurgery

Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease.

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