Proteome analysis of cerebrospinal fluid in patients with Multiple System Atrophy (MSA)

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
S Werz ◽  
V Lehmensiek ◽  
S Süssmuth ◽  
H Mogel ◽  
J Brettschneider ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Multiple System Atrophy ◽  
Proteome Analysis

scholarly journals Cerebrospinal Fluid α-Synuclein Species in Cognitive and Movements Disorders

2021 ◽  
Vol 11 (1) ◽  
pp. 119
Author(s):  
Vasilios C. Constantinides ◽  
Nour K. Majbour ◽  
George P. Paraskevas ◽  
Ilham Abdi ◽  
Bared Safieh-Garabedian ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Multiple System Atrophy ◽  
Progressive Supranuclear Palsy ◽  
Movement Disorders ◽  
Corticobasal Degeneration ◽  
Healthy Controls ◽  
Frontotemporal Degeneration ◽  
Blood Contamination ◽  
Dementia Patients ◽  
Specificity And Sensitivity

Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the differentiation from healthy controls. Studies of α-syn species in patients with other underlying pathologies are lacking. The aim of this study was to investigate possible alterations in CSF α-syn species in a cohort of patients with diverse underlying pathologies. A total of 135 patients were included, comprising Parkinson’s disease (PD; n = 13), multiple system atrophy (MSA; n = 9), progressive supranuclear palsy (PSP; n = 13), corticobasal degeneration (CBD; n = 9), Alzheimer’s disease (AD; n = 51), frontotemporal degeneration (FTD; n = 26) and vascular dementia patients (VD; n = 14). PD patients exhibited higher pS129-α-syn/α-syn ratios compared to FTD (p = 0.045), after exclusion of samples with CSF blood contamination. When comparing movement disorders (i.e., MSA vs. PD vs. PSP vs. CBD), MSA patients had lower α-syn levels compared to CBD (p = 0.024). Patients with a synucleinopathy (PD and MSA) exhibited lower t-α-syn levels (p = 0.002; cut-off value: ≤865 pg/mL; sensitivity: 95%, specificity: 69%) and higher pS129-/t-α-syn ratios (p = 0.020; cut-off value: ≥0.122; sensitivity: 71%, specificity: 77%) compared to patients with tauopathies (PSP and CBD). There are no significant α-syn species alterations in non-synucleinopathies.

scholarly journals Dynamic Cerebrospinal Fluid Flow on MRI in Cortical Cerebellar Atrophy and Multiple System Atrophy-cerebellar Type

2015 ◽  
Vol 54 (14) ◽  
pp. 1717-1723 ◽  
Author(s):  
Yusuke Fukui ◽  
Nozomi Hishikawa ◽  
Kota Sato ◽  
Syoichiro Kono ◽  
Kosuke Matsuzono ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Fluid Flow ◽  
Multiple System Atrophy ◽  
Cerebellar Atrophy ◽  
Cerebrospinal Fluid Flow ◽  
Cerebellar Type ◽  
Cortical Cerebellar Atrophy

Cerebrospinal fluid hypocretin-1 levels in multiple system atrophy

2007 ◽  
Vol 22 (12) ◽  
pp. 1822-1824 ◽  
Author(s):  
Jose Enrique Martinez-Rodriguez ◽  
Klaus Seppi ◽  
Adriana Cardozo ◽  
Alex Iranzo ◽  
Michaela Stampfer-Kountchev ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Multiple System Atrophy ◽  
Hypocretin 1

scholarly journals Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis

2012 ◽  
Vol 74 (6) ◽  
pp. 751-756 ◽  
Author(s):  
Kozo NAKAMURA ◽  
Taku MIYASHO ◽  
Sachiko NOMURA ◽  
Hiroshi YOKOTA ◽  
Tetsuya NAKADE
Keyword(s):  
Cerebrospinal Fluid ◽  
Proteome Analysis

Proteome analysis of cerebrospinal fluid in patients with multiple sclerosis

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
V Lehmensiek ◽  
I Guttmann ◽  
S Suessmuth ◽  
J Brettschneider ◽  
C Palm ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Proteome Analysis

Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia

2010 ◽  
Vol 44 (16) ◽  
pp. 1176-1189 ◽  
Author(s):  
Daniel Martins-de-Souza ◽  
Giuseppina Maccarrone ◽  
Thomas Wobrock ◽  
Inga Zerr ◽  
Philipp Gormanns ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Proteome Analysis ◽  
Potential Biomarkers
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