Differential Inhibition of Matrix Metalloproteinases-2, -9, and -13 Activities by Selected Anthraquinones

Planta Medica ◽  
2009 ◽  
Vol 75 (04) ◽  
pp. 327-329 ◽  
Author(s):  
Claudia Wierzchacz ◽  
Enis Su ◽  
Jens Kolander ◽  
Rolf Gebhardt
Keyword(s):  
Matrix Metalloproteinases ◽  
Differential Inhibition

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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