Cognitive development of a population-based birth cohort within 12 years of follow-up – Results from the ILSE-study

AbstractBackgroundDue to the paucity of previous studies, we wanted to elucidate the pharmacoepidemiology of antipsychotics in schizophrenia in a general population sample, and the association between long-term antipsychotic use and outcomes.MethodsThe sample included 53 schizophrenia subjects from the Northern Finland Birth Cohort 1966 with at least ten years of follow-up (mean 18.6 years since illness onset). Data on lifetime medication and outcomes (remission, Clinical Global Impression [CGI], Social and Occupational Functioning Assessment Scale [SOFAS]) were collected from medical records, interviews, and national registers.ResultsDuring the first two years 22 (42%), between two to five years 17 (32%), and between five to ten years 14 (26%) subjects had used antipsychotics less than half of the time. Drug-free periods became rarer during the follow-up. The mean lifetime daily dose of antipsychotics was 319 mg in chlorpromazine equivalents. A high lifetime average and cumulative dose and antipsychotic polypharmacy were associated with a poorer outcome in all measures, whereas having no drug-free periods was associated with a better SOFAS score and a low proportion of time on antipsychotics with a better CGI score.ConclusionsIn our population-based sample, the use of antipsychotics increased during the first five years of illness and was relatively stable after that. Our results suggest that both low dose and proportion of use, and having no drug-free periods, are associated with better outcomes, which concords with current treatment recommendations and algorithms. High long-term doses and polypharmacy may relate to poor outcomes.

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The Wuhan Twin Birth Cohort (WTBC)

Twin Research and Human Genetics ◽

10.1017/thg.2017.24 ◽

2017 ◽

Vol 20 (4) ◽

pp. 355-362

Author(s):

Jinzhu Zhao ◽

Shaoping Yang ◽

Anna Peng ◽

Zhengmin Qian ◽

Hong Xian ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Medical Information ◽

First Trimester ◽

Population Based ◽

Health Examination ◽

Birth Registry ◽

Twin Birth ◽

First Trimester Of Pregnancy

The Wuhan Pre/Post-Natal Twin Birth Registry (WPTBR) is one of the largest twin birth registries with comprehensive medical information in China. It recruits women from the first trimester of pregnancy and their twins from birth. From January 2006 to May 2016, the total number of twins enrolled in WPTBR is 13,869 twin pairs (27,553 individuals). The WPTBR initiated the Wuhan Twin Birth Cohort (WTBC). The WTBC is a prospective cohort study carried out through incorporation of three samples. The first one comprises 6,920 twin pairs, and the second one, 6,949 twin pairs. Both are population-based samples linked to the WPTBR and include pre- and post-natal information from WPTBR. The second sample includes neonatal blood spots as well. Using a hospital-based approach, we recently developed a third sample with a target enrolment of 1,000 twin pairs and their mothers. These twins are invited, via their parents, to participate in a periodic health examination from the first trimester of pregnancy to 18 years. Biological samples are collected initially from the mother, including blood, urine, cord blood, cord, amniotic fluid, placenta, breast milk and meconium, and vaginal secretions, and later from the twins, including meconium, stool, urine, and blood. This article describes the design, recruitment, follow-up, data collection, and measures, as well as ongoing and planned analyses at the WTBC. The WTBC offers a unique opportunity to follow women from prenatal to postnatal, as well as follow-up of their twins. This cohort study will expand the understanding of genetic and environmental influences on pregnancy and twins’ development in China.

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Greenness and Incident Childhood Asthma: A 10-Year Follow-up in a Population-based Birth Cohort

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.201504-0707le ◽

2015 ◽

Vol 192 (9) ◽

pp. 1131-1133 ◽

Cited By ~ 40

Author(s):

Hind Sbihi ◽

Lillian Tamburic ◽

Mieke Koehoorn ◽

Michael Brauer

Keyword(s):

Birth Cohort ◽

Childhood Asthma ◽

Population Based

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190. Parental Musculoskeletal Disorders Associate With Children’s Prodromal Symptoms of Psychosis: A Population-Based Birth Cohort Study With 8-Year Follow-Up

Schizophrenia Bulletin ◽

10.1093/schbul/sbx021.268 ◽

2017 ◽

Vol 43 (suppl_1) ◽

pp. S100-S100

Author(s):

Lotta Kinnunen ◽

Tanja Nordström ◽

Mika Niemelä ◽

Sami Räsänen ◽

Michael Sawyer ◽

...

Keyword(s):

Cohort Study ◽

Birth Cohort ◽

Musculoskeletal Disorders ◽

Population Based ◽

Birth Cohort Study ◽

Prodromal Symptoms

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Maternal smoking habits and cognitive development of children at age 4 years in a population-based birth cohort

International Journal of Epidemiology ◽

10.1093/ije/dym107 ◽

2007 ◽

Vol 36 (4) ◽

pp. 825-832 ◽

Cited By ~ 127

Author(s):

J. Julvez ◽

N. Ribas-Fito ◽

M. Torrent ◽

M. Forns ◽

R. Garcia-Esteban ◽

...

Keyword(s):

Cognitive Development ◽

Birth Cohort ◽

Maternal Smoking ◽

Population Based ◽

Smoking Habits

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Population-Based Birth Cohort Studies in Epidemiology

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17155276 ◽

2020 ◽

Vol 17 (15) ◽

pp. 5276

Author(s):

Cristina Canova ◽

Anna Cantarutti

Keyword(s):

Cohort Studies ◽

Birth Cohort ◽

Population Based ◽

Birth Cohort Study ◽

Real Word ◽

Special Issue ◽

Birth Cohorts ◽

Medical Birth Register ◽

Cohort Study Design

Birth cohort studies are the most appropriate type of design to determine the causal relationship between potential risk factors during the prenatal or postnatal period and the health status of the newborn up to childhood and potentially adulthood. To date, there has been a growth in interest regarding observational population-based studies which are performed to provide answers to specific research questions for defined populations, for instance, assessing the exposure to environmental pollutants or drugs on the risk of developing a disease. Birth cohorts based on the recruitment and active follow-up of mothers and children allow the collection of biological material, and specific clinical and genetic information. However, they require a considerable amount of time and resources and, besides being usually of limited size, they are exposed to the risk of the loss of subjects to follow-up, with decreased statistical power and possible selection bias. For these reasons, linking the medical birth register with administrative health records for mothers and babies is increasingly being used in countries with a universal healthcare system, allowing researchers to identify large and unselected populations from birth, and to reconstruct relevant traits and care pathways of mothers and newborns. This Special Issue of the International Journal of Environmental Research and Public Health focuses on the current state of knowledge on perinatal and postnatal exposures and adverse pregnancy, maternal, fetal and neonatal outcomes through population-based birth cohort studies, with a specific focus on real-word data. The 12 accepted articles covered a wide range of themes that can be addressed specifically through birth cohort study design; however, only three were based on real word data with record-linkage to health administrative databases. In particular, two papers have addressed the topic of socioeconomic status considering several indicators both at the individual and contextual level. Two papers focused on inflammatory bowel diseases, both as an outcome of perinatal and antibiotic exposure in early life and as a condition associated with asthma, among children identified in a birth cohort based on a Regional Medical Birth Register. Three articles focused on medication use during pregnancy and its impact on maternal and fetal health. The effect of exposure to prenatal environmental risk factors on perinatal and childhood outcomes has been considered in two papers. Two papers analyzed ad hoc nationwide prospective birth cohorts set in Japan and UK. Finally, we included a systematic review with meta-analysis to evaluate the relation between growth restriction at birth and congenital heart defects. We think that this Special Issue may contribute to enriching the discussion of future challenges, opportunities, strengths and limitations for all research topics that can be investigated using a population-based birth cohort study design.

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Oral health follow-up studies in the 1993 Pelotas (Brazil) birth cohort study: methodology and principal results

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2010001000016 ◽

2010 ◽

Vol 26 (10) ◽

pp. 1990-1999 ◽

Cited By ~ 10

Author(s):

Marco A. Peres ◽

Aluísio Jardim Barros ◽

Karen Glazer Peres ◽

Cora Luiza Araújo ◽

Ana M. B. Menezes ◽

...

Keyword(s):

Oral Health ◽

Birth Cohort ◽

Population Based ◽

High Response Rate ◽

Birth Cohort Study ◽

Follow Up Studies ◽

Study Methodology ◽

Number Of Individuals ◽

Carious Teeth

The aim of this study was to describe oral health follow-up studies nested in a birth cohort. A population-based birth cohort was launched in 1993 in Pelotas, Rio Grande do Sul State, Brazil. Two oral health follow-up studies were conducted at six (n = 359) and 12 (n = 339) years of age. A high response rate was observed at 12 years of age; 94.4% of the children examined at six years of age were restudied in 2005. The mean DMF-T index at age 12 was 1.2 (SD = 1.6) for the entire sample, ranging from 0.6 (SD = 1.1) for children that were caries-free at age six, 1.3 (SD = 1.5) for those with 1-3 carious teeth at six years, and 1.8 (SD = 1.8) for those with 4-19 carious teeth at six years (p < 0.01). The number of individuals with severe malocclusions at 12 years was proportional to the number of malocclusions at six years. Oral health problems in early adolescence were more prevalent in individuals with dental problems at six years of age.

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