Bioavailability of Oral Iron Drugs as Judged by a 59Fe-Whole-body Counting Technique in Patients with Iron Deficiency Anaemia

SummaryA preliminary study of iron absorption by whole body counting was carried on a group of 16 women. The cases included 8 patients suffering from iron deficiency anaemia and various infections as well as 8 healthy controls. High iron absorption is associated with iron dificiency, these changes being more marked in iron deficient controls than in those with infection or malignancy. In iron deficient controls results of whole body counting correlate very well with other haematological investigations.

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Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

Scientific Reports ◽

10.1038/s41598-021-93155-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Hafid O. Al-Hassi ◽

Oliver Ng ◽

Rayko Evstatiev ◽

Manel Mangalika ◽

Natalie Worton ◽

...

Keyword(s):

Colorectal Cancer ◽

Iron Deficiency ◽

Iron Metabolism ◽

Iron Deficiency Anaemia ◽

Iron Transport ◽

Intravenous Iron ◽

Oral Iron ◽

Iron Loading ◽

Deficiency Anaemia ◽

Iron Treatment

AbstractOral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.

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PSY4 A SYSTEMATIC LITERATURE REVIEW AND INDIRECT COMPARISON OF IRON ISOMALTOSIDE AND FERRIC CARBOXYMALTOSE IN IRON DEFICIENCY ANAEMIA AFTER FAILURE OR INTOLERANCE OF ORAL IRON TREATMENT

Value in Health ◽

10.1016/j.jval.2019.04.1829 ◽

2019 ◽

Vol 22 ◽

pp. S374

Author(s):

R. Pollock ◽

G. Muduma

Keyword(s):

Iron Deficiency ◽

Literature Review ◽

Systematic Literature Review ◽

Iron Deficiency Anaemia ◽

Indirect Comparison ◽

Oral Iron ◽

Ferric Carboxymaltose ◽

Deficiency Anaemia ◽

Iron Treatment

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Simple test for ingested iron

Drug and Therapeutics Bulletin ◽

10.1136/dtb.4.25.100 ◽

1966 ◽

Vol 4 (25) ◽

pp. 100-100

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Oral Iron ◽

Confirmatory Test ◽

Simple Test ◽

Deficiency Anaemia ◽

Experienced Observer

A surprisingly high proportion of patients do not take the drugs prescribed for them,1 and failure of iron deficiency anaemia to respond to oral iron is often due to failure to take the medication. An experienced observer can often tell from the appearance of the stools whether a patient is taking iron, but a simple objective confirmatory test may be needed. Such a test has recently been described.2

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Intravenous versus oral iron therapy in treatment of postpartum anaemia

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20173462 ◽

2017 ◽

Vol 6 (8) ◽

pp. 3454

Author(s):

Neelima Agarwal ◽

Preeti Sharma

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anaemia ◽

Ferrous Sulphate ◽

Intravenous Iron ◽

Hemoglobin Level ◽

Oral Iron ◽

Chi Square ◽

Deficiency Anaemia ◽

Significant Difference ◽

Red Cell Indices

Background: Postpartum iron deficiency anaemia (IDA) is common in women. Most women are treated with either oral iron supplementation or blood transfusion. Hence, the aim of our study was to compare the effect of treatment with either oral ferrous sulphate or intravenous ferrous sucrose on postpartum IDA.Methods: 100 postpartum women with proven iron deficiency anaemia with hemoglobin <9gm/dl and serum ferritin <15 µgm/l were included in the study. They were randomized to receive either oral ferrous sulphate 200 mg twice daily for 6 weeks (group 1) or intravenous ferrous sucrose 200 mg, two to three doses given on alternate days (group 2). Total iron deficit was calculated using a standard formula. Target hemoglobin was 11 gm/dl. Results were analysed by the students t-test and chi-square test. Hemoglobin, hematocrit, red cell indices and ferritin were measured on day 2-3, 1-2 weeks and 6 weeks postpartumResults: By 1-2 weeks, hemoglobin level in women treated with intravenous iron had risen from 7.81±0.849 to 9.88±0.760 gm/dl which was more than those treated with oral iron (p<0.01); although by 6 weeks, there was no significant difference between the two groups. Ferritin levels rose rapidly in those treated with intravenous iron and remained significantly higher than in those treated with oral iron (p<0.01).Conclusions: Intravenous iron sucrose increases the hemoglobin level more rapidly than oral ferrous sulphate in women with postpartum IDA. It also replenishes iron stores more rapidly.

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