Study designs to compare new colonoscopic techniques: clinical considerations, data analysis, and sample size calculations

Endoscopy ◽  
2013 ◽  
Vol 45 (11) ◽  
pp. 922-927 ◽  
Author(s):  
Frank van den Broek ◽  
Teaco Kuiper ◽  
Evelien Dekker ◽  
Aeilko Zwinderman ◽  
Paul Fockens ◽  
...  
Keyword(s):  
Data Analysis ◽  
Sample Size ◽  
Sample Size Calculations ◽  
Clinical Considerations ◽  
Study Designs

Estimates, power and sample size calculations for two-sample ordinal outcomes under before-after study designs

2003 ◽  
Vol 22 (11) ◽  
pp. 1807-1818 ◽  
Author(s):  
Pamela A. Ohman Strickland ◽  
Shou-En Lu
Keyword(s):  
Sample Size ◽  
Sample Size Calculations ◽  
Study Designs

scholarly journals Virtual reality-based relaxation for enhancement of perioperative well-being and quality of life: protocol for a randomised pilot trial

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e044193
Author(s):  
Matthias Christian Schrempf ◽  
Julian Quirin Petzold ◽  
Hugo Vachon ◽  
Morten Aagaard Petersen ◽  
Johanna Gutschon ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Virtual Reality ◽  
Sample Size ◽  
Stress Reduction ◽  
Pilot Trial ◽  
Well Being ◽  
Coping Resources ◽  
Patients With Cancer ◽  
Sample Size Calculations

IntroductionPatients with cancer undergoing surgery often suffer from reduced quality of life and various forms of distress. Untreated distress can negatively affect coping resources as well as surgical and oncological outcomes. A virtual reality-based stress reduction intervention may increase quality of life and well-being and reduce distress in the perioperative phase for patients with cancer. This pilot trial aims to explore the feasibility of the proposed intervention, assess patient acceptability and obtain estimates of effect to provide data for sample size calculations.Methods and analysisPatients with colorectal cancer and liver metastasis undergoing elective surgery will be recruited for this single-centre, randomised pilot trial with a three-arm design. A total of 54 participants will be randomised at 1:1:1 ratio to one of two intervention groups or a control receiving standard treatment. Those randomised to an intervention group will either receive perioperative virtual reality-based stress reduction exercises twice daily or listen to classical music twice daily. Primary feasibility outcomes are number and proportions of participants recruited, screened, consented and randomised. Furthermore, adherence to the intervention, compliance with the completion of the quality of life questionnaires and feasibility of implementing the trial procedures will be assessed. Secondary clinical outcomes are measurements of the effectiveness of the interventions to inform sample size calculations.Ethics and disseminationThe study protocol, the patient information and the informed consent form have been approved by the ethics committee of the Ludwigs-Maximilians-University, Munich, Germany (Reference Number: 19–915). Study findings will be submitted for publication in peer-reviewed journals.Trial registration numberDRKS00020909.

scholarly journals ‘Statistical Irreproducibility’ Does Not Improve with Larger Sample Size: How to Quantify and Address Disease Data Multimodality in Human and Animal Research

2021 ◽  
Vol 11 (3) ◽  
pp. 234
Author(s):  
Abigail R. Basson ◽  
Fabio Cominelli ◽  
Alexander Rodriguez-Palacios
Keyword(s):  
Sample Size ◽  
Data Visualization ◽  
Random Sampling ◽  
Intestinal Inflammation ◽  
Random Number Generation ◽  
Outcome Data ◽  
Multimodal Distributions ◽  
Disease Subtypes ◽  
Study Designs ◽  
Larger Sample

Poor study reproducibility is a concern in translational research. As a solution, it is recommended to increase sample size (N), i.e., add more subjects to experiments. The goal of this study was to examine/visualize data multimodality (data with >1 data peak/mode) as cause of study irreproducibility. To emulate the repetition of studies and random sampling of study subjects, we first used various simulation methods of random number generation based on preclinical published disease outcome data from human gut microbiota-transplantation rodent studies (e.g., intestinal inflammation and univariate/continuous). We first used unimodal distributions (one-mode, Gaussian, and binomial) to generate random numbers. We showed that increasing N does not reproducibly identify statistical differences when group comparisons are repeatedly simulated. We then used multimodal distributions (>1-modes and Markov chain Monte Carlo methods of random sampling) to simulate similar multimodal datasets A and B (t-test-p = 0.95; N = 100,000), and confirmed that increasing N does not improve the ‘reproducibility of statistical results or direction of the effects’. Data visualization with violin plots of categorical random data simulations with five-integer categories/five-groups illustrated how multimodality leads to irreproducibility. Re-analysis of data from a human clinical trial that used maltodextrin as dietary placebo illustrated multimodal responses between human groups, and after placebo consumption. In conclusion, increasing N does not necessarily ensure reproducible statistical findings across repeated simulations due to randomness and multimodality. Herein, we clarify how to quantify, visualize and address disease data multimodality in research. Data visualization could facilitate study designs focused on disease subtypes/modes to help understand person–person differences and personalized medicine.

scholarly journals Intra-cluster correlations from the CLustered OUtcome Dataset bank to inform the design of longitudinal cluster trials

2021 ◽  
pp. 174077452110208
Author(s):  
Elizabeth Korevaar ◽  
Jessica Kasza ◽  
Monica Taljaard ◽  
Karla Hemming ◽  
Terry Haines ◽  
...  
Keyword(s):  
Sample Size ◽  
Discrete Time ◽  
Correlation Coefficients ◽  
Time Decay ◽  
Randomised Trials ◽  
Cluster Randomised Trials ◽  
Cluster Randomised ◽  
Sample Size Calculations ◽  
Correlation Structures ◽  
Cluster Correlation

Background: Sample size calculations for longitudinal cluster randomised trials, such as crossover and stepped-wedge trials, require estimates of the assumed correlation structure. This includes both within-period intra-cluster correlations, which importantly differ from conventional intra-cluster correlations by their dependence on period, and also cluster autocorrelation coefficients to model correlation decay. There are limited resources to inform these estimates. In this article, we provide a repository of correlation estimates from a bank of real-world clustered datasets. These are provided under several assumed correlation structures, namely exchangeable, block-exchangeable and discrete-time decay correlation structures. Methods: Longitudinal studies with clustered outcomes were collected to form the CLustered OUtcome Dataset bank. Forty-four available continuous outcomes from 29 datasets were obtained and analysed using each correlation structure. Patterns of within-period intra-cluster correlation coefficient and cluster autocorrelation coefficients were explored by study characteristics. Results: The median within-period intra-cluster correlation coefficient for the discrete-time decay model was 0.05 (interquartile range: 0.02–0.09) with a median cluster autocorrelation of 0.73 (interquartile range: 0.19–0.91). The within-period intra-cluster correlation coefficients were similar for the exchangeable, block-exchangeable and discrete-time decay correlation structures. Within-period intra-cluster correlation coefficients and cluster autocorrelations were found to vary with the number of participants per cluster-period, the period-length, type of cluster (primary care, secondary care, community or school) and country income status (high-income country or low- and middle-income country). The within-period intra-cluster correlation coefficients tended to decrease with increasing period-length and slightly decrease with increasing cluster-period sizes, while the cluster autocorrelations tended to move closer to 1 with increasing cluster-period size. Using the CLustered OUtcome Dataset bank, an RShiny app has been developed for determining plausible values of correlation coefficients for use in sample size calculations. Discussion: This study provides a repository of intra-cluster correlations and cluster autocorrelations for longitudinal cluster trials. This can help inform sample size calculations for future longitudinal cluster randomised trials.

Sample size calculations for ROC studies: parametric robustness and Bayesian nonparametrics

2011 ◽  
Vol 31 (2) ◽  
pp. 131-142 ◽  
Author(s):  
Dunlei Cheng ◽  
Adam J. Branscum ◽  
Wesley O. Johnson
Keyword(s):  
Sample Size ◽  
Bayesian Nonparametrics ◽  
Sample Size Calculations ◽  
Parametric Robustness

scholarly journals A comment on sample size calculations for binomial confidence intervals

2013 ◽  
Vol 40 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Lai Wei ◽  
Alan D. Hutson
Keyword(s):  
Sample Size ◽  
Confidence Intervals ◽  
Sample Size Calculations

PENGARUH BUDAYA KERJA, KEPEMIMPINAN, DISIPLIN KERJA DAN KOMPENSASI TERHADAP KINERJA KARYAWAN PT. KAI DAOP 5 PURWOKERTO

2017 ◽  
Vol 3 (1) ◽  
pp. 87-100
Author(s):  
Karsono , ◽  
Denok Kurniasih ◽  
Dyah Retna Puspita
Keyword(s):  
Regression Analysis ◽  
Data Analysis ◽  
Sample Size ◽  
Multiple Regression Analysis ◽  
Compensation Effect ◽  
Employee Performance ◽  
Primary Data ◽  
Work Culture ◽  
Study Population

Abstract: Employee performance is very important for an organization to achieve its goals. This study aims to analyze the influence of work culture, on employee performance, leadership on employee performance, work discipline on employee performance, compensation on employee performance and work culture, leadership, work discipline, compensation on employee performance at PT. KAI Daop 5 Purwokerto. The study population is all employees of PT. KAI Daop 5 Purwokerto as many as 623 employees. Determination of sample size with Slovin formula obtained by 86 respondents. The data used is the primary data obtained from the questionnaires distributed to respondents.Tehnik data analysis used is a quantitative approach. The data of the research were analyzed using multiple regression analysis. The results showed that: Work culture affect the performance of employees means that if the work culture increases then the performance of employees will increase. Leadership affects the performance of employees means that if the existing leadership is conducive to work then the performance of employees will increase, work discipline does not affect the performance of employees means employees who discipline work high and employees who work discipline less have the same performance height, Compensation effect on the performance of meaning if the compensation increases then employee performance will increase, work culture, leadership, work discipline and compensation together affect the employee's performance, meaning that if work culture, leadership, work discipline and compensation together increase the employee performance will increase. Keywords: Working Culture, Leadership, Work Discipline, Compensation, Employee Performance. Abstrak: Kinerja pegawai merupakan hal yang sangat penting bagi organisasi untuk mencapai tujuannya. Penelitian ini bertujuan untuk menganalisis pengaruh budaya kerja, terhadap kinerja pegawai, kepemimpinan terhadap kinerja pegawai, disiplin kerja terhadap kinerja pegawai, kompensasi terhadap kinerja pegawai dan budaya kerja, kepemimpinan, disiplin kerja, kompensasi terhadap kinerja pegawai di PT. KAI Daop 5 Purwokerto. Populasi penelitian adalah semua karyawan PT. KAI Daop 5 Purwokerto sebanyak 623 orang karyawan. Penentuan ukuran sampel dengan rumus Slovin diperoleh sampel sebanyak 86 responden. Data yang digunakan adalah data primer yang diperoleh dari kuisioner yang dibagikan kepada responden.Tehnik analisis data yang digunakan adalah pendekatan kuantitatif. Data hasil penelitian dianalisis menggunakan analisis regresi berganda. Hasil penelitian menunjukkan bahwa: Budaya kerja berpengaruh terhadap kinerja pegawai artinya apabila budaya kerja meningkat maka kinerja karyawan akan meningkat. Kepemimpinan berpengaruh terhadap kinerja pegawai artinya apabila kepemimpinan yang ada sangat kondusif untuk bekerja maka kinerja karyawan akan meningkat, Disiplin kerja tidak berpengaruh terhadap kinerja pegawai artinya pegawai yang disiplin kerjanya tinggi dan pegawai yang disiplin kerjanya kurang memiliki kinerja yang sama tingginya, Kompensasi berpengaruh terhadap kinerja artinya apabila kompensasi meningkat maka kinerja karyawan akan meningkat, Budaya kerja, kepemimpinan, disiplin kerja dan kompensasi secara bersama-sama berpengaruh terhadap kinerja pegawai, artinya apabila budaya kerja, kepemimpinan, disiplin kerja dan kompensasi  secara bersama-sama mengalami peningkatan maka kinerja karyawan akan meningkat. Kata Kunci:  Budaya Kerja, Kepemimpinan, Disiplin Kerja, Kompensasi, Kinerja   Pegawai.

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