A novel bioassay to identify anti-virulence leads against gram-positive bacterial pathogens

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Todd ◽  
DB Zich ◽  
AR Horswill ◽  
NB Cech
Keyword(s):  
Bacterial Pathogens ◽  
Gram Positive

Iron acquisition by Gram-positive bacterial pathogens

2002 ◽  
Vol 4 (11) ◽  
pp. 1149-1156 ◽  
Author(s):  
Jeremy S Brown ◽  
David W Holden
Keyword(s):  
Iron Acquisition ◽  
Bacterial Pathogens ◽  
Gram Positive

Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens

2018 ◽  
Vol 152 ◽  
pp. 318-328 ◽  
Author(s):  
Moustafa ElAwamy ◽  
Haroon Mohammad ◽  
Abdelrahman Hussien ◽  
Nader S. Abutaleb ◽  
Mohamed Hagras ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Bacterial Pathogens ◽  
Multidrug Resistant ◽  
Gram Positive ◽  
Spectrum Activity ◽  
Broad Spectrum Activity

Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

RSC Advances ◽  
2015 ◽  
Vol 5 (90) ◽  
pp. 73660-73669 ◽  
Author(s):  
Lili Yan ◽  
Jingjing Wu ◽  
Heng Chen ◽  
Shaowu Zhang ◽  
Zhi Wang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Bacterial Pathogens ◽  
Gram Positive ◽  
Good Antibacterial Activity ◽  
In Vitro Antibacterial Activity

A series of novel fluoroalkyl-substituted pyrazole bearing oxazolidinone derivatives were synthesized and evaluated for their antibacterial activity against six Gram-positive bacterial pathogens. Most have good antibacterial activity, three being comparable to linezolid.

scholarly journals Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative Bacteria

2006 ◽  
Vol 50 (1) ◽  
pp. 385-387 ◽  
Author(s):  
Ed T. Buurman ◽  
Kenneth D. Johnson ◽  
Roxanne K. Kelly ◽  
Kathy MacCormack
Keyword(s):  
Escherichia Coli ◽  
Haemophilus Influenzae ◽  
Mode Of Action ◽  
Bacterial Pathogens ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Modes Of Action

ABSTRACT Naphthyridones that were recently described as a class of translation inhibitors in gram-positive bacteria mediate their mode of action via GyrA in Haemophilus influenzae and Escherichia coli. These are the first examples of compounds in which modes of action in different bacterial pathogens are mediated through widely different targets.

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