Concordance of immunohistochemistry in core needle biopsy and surgical specimen in invasive breast cancer

2016 ◽  
Vol 13 (02) ◽  
Author(s):  
C Hecht ◽  
L Knabben ◽  
K Strahm ◽  
P Sager ◽  
M Mueller
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Surgical Specimen ◽  
Core Needle

The reliability of HER2-status determination from core-needle-biopsies and surgical specimens: A comparison of two established test methods (IHC, CISH)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22141-e22141
Author(s):  
V. Wolf ◽  
R. Groβe ◽  
J. Erggelet ◽  
H. J. Holzhausen ◽  
S. Hauptmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
In Situ Hybridisation ◽  
Test Method ◽  
Her2 Status ◽  
Surgical Specimen ◽  
Core Needle ◽  
Significant Difference ◽  
Her 2

e22141 Background: A milestone of breast-cancer therapy was the discovery of HER-2 entailing special targeted therapy with improved prognosis. The HER-2-status is routinely assessed through immunohistochemistry (IHC; HercepTest) showing protein over-expression and is double-checked with in-situ-hybridisation (ISH) demonstrating gene amplification in equivocal cases. It is questioned whether these methods achieve identical results in core-needle-biopsies and in excisional tumor specimens. Methods: We performed a retrospective comparative study in order to address these questions. From 01/03–06/08 we collected the HercepTest results from both core-needle-biopsy and surgical specimen of 109 breast cancer patients in our institute and compared these to newly evaluated chromogenic ISH (CISH) results for both specimen types in order to assess the reliability of HER-2- diagnosis of both methodological approaches and of specimen type. Results: We found no significant difference in the HER- 2-status determined from either needle-biopsies or surgical specimens irrespective of the test used. For the overall comparison (218 specimens) of HercepTest and CISH we found only slight, non-significant deviations. Four cases were CISH-negative in spite of HercepTest scoring of 3+. Vice versa, five out of the total of 38 (17.4%) CISH-positives did not correspond to the HercepTest results of 0 or 1+. Conclusions: Though not significant, there is some inconsistency in the HER-2-determination depending on the test-method, leaving these cases equivocal. In accordance with the literature, we therefore recommend to at least double-check samples with 2+ in the HercepTest as it is the current standard. Our data support the use of core-needle-biopsy as a reliable tissue sample for HER-2-diagnosis. [Table: see text]

Reliability of histological malignancy grade, ER and HER2 status on core needle biopsy vs surgical specimen in breast cancer

Apmis ◽  
2013 ◽  
Vol 122 (9) ◽  
pp. 750-754 ◽  
Author(s):  
Helga D. Munch-Petersen ◽  
Birgitte B. Rasmussen ◽  
Eva Balslev
Keyword(s):  
Breast Cancer ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Her2 Status ◽  
Surgical Specimen ◽  
Core Needle ◽  
Malignancy Grade ◽  
Histological Malignancy

Predictors of Invasive Breast Cancer in Patients With Ductal Carcinoma In Situ in Ultrasound-Guided Core Needle Biopsy

2018 ◽  
Vol 38 (2) ◽  
pp. 481-488 ◽  
Author(s):  
Yoon Joo Shin ◽  
Sun Mi Kim ◽  
Bo La Yun ◽  
Mijung Jang ◽  
Bohyoung Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma In Situ ◽  
Invasive Breast Cancer ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Ultrasound Guided ◽  
Core Needle

scholarly journals Development and Evaluation of a Prediction Model for Underestimated Invasive Breast Cancer in Women with Ductal Carcinoma In Situ at Stereotactic Large Core Needle Biopsy

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77826 ◽  
Author(s):  
Suzanne C. E. Diepstraten ◽  
Stephanie M. W. Y. van de Ven ◽  
Ruud M. Pijnappel ◽  
Petra H. M. Peeters ◽  
Maurice A. A. J. van den Bosch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma In Situ ◽  
Invasive Breast Cancer ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Large Core ◽  
Core Needle
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